Analytical techniques and methods for study of drug-lipid membrane interactions
A better elucidation of molecular mechanisms underlying drug-membrane interaction is of great importance for drug research and development. To date, different biochemical and biophysical methods have been developed to study biological membranes at molecular level. This review focuses on the recent a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2017-11-01
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| Series: | Reviews in Analytical Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/revac-2017-0012 |
| _version_ | 1818666754459566080 |
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| author | Li Hewen Zhao Tao Sun Zhihua |
| author_facet | Li Hewen Zhao Tao Sun Zhihua |
| author_sort | Li Hewen |
| collection | DOAJ |
| description | A better elucidation of molecular mechanisms underlying drug-membrane interaction is of great importance for drug research and development. To date, different biochemical and biophysical methods have been developed to study biological membranes at molecular level. This review focuses on the recent applications and achievements of modern analytical techniques in the study of drug interactions with lipid membranes, including chromatography, spectrometry, calorimetry, and acoustic sensing. The merits and limitations of these techniques were compared and critically discussed. Moreover, various types of biomimetic model membranes including liposomes, lipid monolayers, and supported lipid monolayers/bilayers were described. General mechanisms underlying drug-membrane interaction process were also briefly introduced. |
| first_indexed | 2024-12-17T06:09:33Z |
| format | Article |
| id | doaj.art-5add4bcddf4f4ab18c5bfb520d9ff545 |
| institution | Directory Open Access Journal |
| issn | 0793-0135 2191-0189 |
| language | English |
| last_indexed | 2024-12-17T06:09:33Z |
| publishDate | 2017-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Reviews in Analytical Chemistry |
| spelling | doaj.art-5add4bcddf4f4ab18c5bfb520d9ff5452022-12-21T22:00:41ZengDe GruyterReviews in Analytical Chemistry0793-01352191-01892017-11-0137123324310.1515/revac-2017-0012Analytical techniques and methods for study of drug-lipid membrane interactionsLi Hewen0Zhao Tao1Sun Zhihua2College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, 201620, ChinaCollege of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, 201620, ChinaCollege of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, 201620, ChinaA better elucidation of molecular mechanisms underlying drug-membrane interaction is of great importance for drug research and development. To date, different biochemical and biophysical methods have been developed to study biological membranes at molecular level. This review focuses on the recent applications and achievements of modern analytical techniques in the study of drug interactions with lipid membranes, including chromatography, spectrometry, calorimetry, and acoustic sensing. The merits and limitations of these techniques were compared and critically discussed. Moreover, various types of biomimetic model membranes including liposomes, lipid monolayers, and supported lipid monolayers/bilayers were described. General mechanisms underlying drug-membrane interaction process were also briefly introduced.https://doi.org/10.1515/revac-2017-0012bioanalysisdrug-membrane interactionsdrugslipid membrane |
| spellingShingle | Li Hewen Zhao Tao Sun Zhihua Analytical techniques and methods for study of drug-lipid membrane interactions Reviews in Analytical Chemistry bioanalysis drug-membrane interactions drugs lipid membrane |
| title | Analytical techniques and methods for study of drug-lipid membrane interactions |
| title_full | Analytical techniques and methods for study of drug-lipid membrane interactions |
| title_fullStr | Analytical techniques and methods for study of drug-lipid membrane interactions |
| title_full_unstemmed | Analytical techniques and methods for study of drug-lipid membrane interactions |
| title_short | Analytical techniques and methods for study of drug-lipid membrane interactions |
| title_sort | analytical techniques and methods for study of drug lipid membrane interactions |
| topic | bioanalysis drug-membrane interactions drugs lipid membrane |
| url | https://doi.org/10.1515/revac-2017-0012 |
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