Cladieunicellins M–Q, New Eunicellins from Cladiella sp.
Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-04-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/12/4/2144 |
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| author | Tsung-Hung Chen Wu-Fu Chen Zhi-Hong Wen Mei-Chin Lu Wei-Hsien Wang Jan-Jung Li Yang-Chang Wu Ping-Jyun Sung |
| author_facet | Tsung-Hung Chen Wu-Fu Chen Zhi-Hong Wen Mei-Chin Lu Wei-Hsien Wang Jan-Jung Li Yang-Chang Wu Ping-Jyun Sung |
| author_sort | Tsung-Hung Chen |
| collection | DOAJ |
| description | Five new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues. |
| first_indexed | 2024-04-13T09:19:46Z |
| format | Article |
| id | doaj.art-5adff2ddafd647499c55499bae3d21e1 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-13T09:19:46Z |
| publishDate | 2014-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-5adff2ddafd647499c55499bae3d21e12022-12-22T02:52:38ZengMDPI AGMarine Drugs1660-33972014-04-011242144215510.3390/md12042144md12042144Cladieunicellins M–Q, New Eunicellins from Cladiella sp.Tsung-Hung Chen0Wu-Fu Chen1Zhi-Hong Wen2Mei-Chin Lu3Wei-Hsien Wang4Jan-Jung Li5Yang-Chang Wu6Ping-Jyun Sung7Graduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, TaiwanDepartment of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, TaiwanGraduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanNational Museum of Marine Biology and Aquarium, Pingtung 944, TaiwanSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, TaiwanGraduate Institute of Marine Biotechnology, Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, TaiwanFive new 7α-hydroxyeunicellin-based diterpenoids, designated as cladieunicellins M–Q (1–5), were isolated from a Formosan octocoral Cladiella sp. The structures of 1–5 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1–5 against the human leukemia Molt 4 and HL 60 is also described. Among them, compounds 1, 3 and 5 exhibited moderate cytotoxicity toward Molt 4 cells with IC50 values 16.43, 14.17 and 15.55 μM, respectively. Preliminary SAR (structure activity relationship) information was obtained from these compounds and their analogues.http://www.mdpi.com/1660-3397/12/4/2144eunicellinCladiellacladieunicellincytotoxicity |
| spellingShingle | Tsung-Hung Chen Wu-Fu Chen Zhi-Hong Wen Mei-Chin Lu Wei-Hsien Wang Jan-Jung Li Yang-Chang Wu Ping-Jyun Sung Cladieunicellins M–Q, New Eunicellins from Cladiella sp. Marine Drugs eunicellin Cladiella cladieunicellin cytotoxicity |
| title | Cladieunicellins M–Q, New Eunicellins from Cladiella sp. |
| title_full | Cladieunicellins M–Q, New Eunicellins from Cladiella sp. |
| title_fullStr | Cladieunicellins M–Q, New Eunicellins from Cladiella sp. |
| title_full_unstemmed | Cladieunicellins M–Q, New Eunicellins from Cladiella sp. |
| title_short | Cladieunicellins M–Q, New Eunicellins from Cladiella sp. |
| title_sort | cladieunicellins m q new eunicellins from cladiella sp |
| topic | eunicellin Cladiella cladieunicellin cytotoxicity |
| url | http://www.mdpi.com/1660-3397/12/4/2144 |
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