High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC
Abstract The heterogeneity of triple‐negative breast cancers (TNBC) remains challenging for various treatments. Ferroptosis, a recently identified form of cell death resulting from the unrestrained peroxidation of phospholipids, represents a potential vulnerability in TNBC. In this study, a high int...
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202305546 |
| _version_ | 1827233431705092096 |
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| author | Xiangrong Yu Xuejing Li Qingwang Chen Siyu Wang Ruizhe Xu Ying He Xifeng Qin Jun Zhang Wuli Yang Leming Shi Ligong Lu Yuanting Zheng Zhiqing Pang Shaojun Peng |
| author_facet | Xiangrong Yu Xuejing Li Qingwang Chen Siyu Wang Ruizhe Xu Ying He Xifeng Qin Jun Zhang Wuli Yang Leming Shi Ligong Lu Yuanting Zheng Zhiqing Pang Shaojun Peng |
| author_sort | Xiangrong Yu |
| collection | DOAJ |
| description | Abstract The heterogeneity of triple‐negative breast cancers (TNBC) remains challenging for various treatments. Ferroptosis, a recently identified form of cell death resulting from the unrestrained peroxidation of phospholipids, represents a potential vulnerability in TNBC. In this study, a high intensity focused ultrasound (HIFU)‐driven nanomotor is developed for effective therapy of TNBC through induction of ferroptosis. Through bioinformatics analysis of typical ferroptosis‐associated genes in the FUSCCTNBC dataset, gambogic acid is identified as a promising ferroptosis drug and loaded it into the nanomotor. It is found that the rapid motion of nanomotors propelled by HIFU significantly enhanced tumor accumulation and penetration. More importantly, HIFU not only actuated nanomotors to trigger effective ferroptosis of TNBC cells, but also drove nanomotors to activate ferroptosis‐mediated antitumor immunity in primary and metastatic TNBC models, resulting in effective tumor regression and prevention of metastases. Overall, HIFU‐driven nanomotors show great potential for ferroptosis‐immunotherapy of TNBC. |
| first_indexed | 2024-04-24T08:04:52Z |
| format | Article |
| id | doaj.art-5ae21326d72a4e579a0c9786e3816a6f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2025-03-21T19:33:13Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-5ae21326d72a4e579a0c9786e3816a6f2024-06-03T14:05:50ZengWileyAdvanced Science2198-38442024-04-011115n/an/a10.1002/advs.202305546High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBCXiangrong Yu0Xuejing Li1Qingwang Chen2Siyu Wang3Ruizhe Xu4Ying He5Xifeng Qin6Jun Zhang7Wuli Yang8Leming Shi9Ligong Lu10Yuanting Zheng11Zhiqing Pang12Shaojun Peng13Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University) Zhuhai Guangdong 519000 P. R. ChinaKey Laboratory of Smart Drug Delivery, School of Pharmacy Fudan University Shanghai 201203 P.R. ChinaState Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute Fudan University 2005 Songhu Road Shanghai 200438 P.R. ChinaKey Laboratory of Smart Drug Delivery, School of Pharmacy Fudan University Shanghai 201203 P.R. ChinaKey Laboratory of Smart Drug Delivery, School of Pharmacy Fudan University Shanghai 201203 P.R. ChinaKey Laboratory of Smart Drug Delivery, School of Pharmacy Fudan University Shanghai 201203 P.R. ChinaKey Laboratory of Smart Drug Delivery, School of Pharmacy Fudan University Shanghai 201203 P.R. ChinaDepartment of Radiology, Huashan Hospital, State Key Laboratory of Medical Neurobiology Fudan University 12 Wulumuqi Middle Road Shanghai 200040 ChinaState Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science Fudan University Shanghai 200433 ChinaState Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute Fudan University 2005 Songhu Road Shanghai 200438 P.R. ChinaGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University) Zhuhai Guangdong 519000 P. R. ChinaState Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute Fudan University 2005 Songhu Road Shanghai 200438 P.R. ChinaKey Laboratory of Smart Drug Delivery, School of Pharmacy Fudan University Shanghai 201203 P.R. ChinaGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University) Zhuhai Guangdong 519000 P. R. ChinaAbstract The heterogeneity of triple‐negative breast cancers (TNBC) remains challenging for various treatments. Ferroptosis, a recently identified form of cell death resulting from the unrestrained peroxidation of phospholipids, represents a potential vulnerability in TNBC. In this study, a high intensity focused ultrasound (HIFU)‐driven nanomotor is developed for effective therapy of TNBC through induction of ferroptosis. Through bioinformatics analysis of typical ferroptosis‐associated genes in the FUSCCTNBC dataset, gambogic acid is identified as a promising ferroptosis drug and loaded it into the nanomotor. It is found that the rapid motion of nanomotors propelled by HIFU significantly enhanced tumor accumulation and penetration. More importantly, HIFU not only actuated nanomotors to trigger effective ferroptosis of TNBC cells, but also drove nanomotors to activate ferroptosis‐mediated antitumor immunity in primary and metastatic TNBC models, resulting in effective tumor regression and prevention of metastases. Overall, HIFU‐driven nanomotors show great potential for ferroptosis‐immunotherapy of TNBC.https://doi.org/10.1002/advs.202305546ferroptosisgambogic acidhigh intensity focused ultrasoundimmunotherapynanomotorstriple‐negative breast cancers |
| spellingShingle | Xiangrong Yu Xuejing Li Qingwang Chen Siyu Wang Ruizhe Xu Ying He Xifeng Qin Jun Zhang Wuli Yang Leming Shi Ligong Lu Yuanting Zheng Zhiqing Pang Shaojun Peng High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC Advanced Science ferroptosis gambogic acid high intensity focused ultrasound immunotherapy nanomotors triple‐negative breast cancers |
| title | High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC |
| title_full | High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC |
| title_fullStr | High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC |
| title_full_unstemmed | High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC |
| title_short | High Intensity Focused Ultrasound‐Driven Nanomotor for Effective Ferroptosis‐Immunotherapy of TNBC |
| title_sort | high intensity focused ultrasound driven nanomotor for effective ferroptosis immunotherapy of tnbc |
| topic | ferroptosis gambogic acid high intensity focused ultrasound immunotherapy nanomotors triple‐negative breast cancers |
| url | https://doi.org/10.1002/advs.202305546 |
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