Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients
Background & aim: Considering that overweight and obesity in transplant patients are considered as a risk factor for the occurrence of metabolic disorders, heart diseases and reduced kidney function, therefore, the purpose of the present study was to determine and investigate the relationship be...
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| Format: | Article |
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Yasuj University Of Medical Sciences
2022-08-01
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| Series: | Armaghane Danesh Bimonthly Journal |
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| Online Access: | http://armaghanj.yums.ac.ir/article-1-3282-en.pdf |
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| author | V Ebrahimzadeh Attari MR Ardalan S Abedi Azar J Etemadi A Malik Mahdavi A Madah |
| author_facet | V Ebrahimzadeh Attari MR Ardalan S Abedi Azar J Etemadi A Malik Mahdavi A Madah |
| author_sort | V Ebrahimzadeh Attari |
| collection | DOAJ |
| description | Background & aim: Considering that overweight and obesity in transplant patients are considered as a risk factor for the occurrence of metabolic disorders, heart diseases and reduced kidney function, therefore, the purpose of the present study was to determine and investigate the relationship between anthropometric indicators and kidney function. In addition, the serum levels of fibroblast growth factor-23 and matrix gamma carboxyglutamate protein were markers of cardiovascular disease risk in kidney transplant patients.
Methods: The present study was conducted as a cross-sectional study in 2016-2019. Ninety kidney transplant patients referred to Tabriz Imam Reza (AS) hospital clinic, between 18 and 70 years of age and had normal kidney function and were within 6-12 months after transplant, were selected. Weight, height, waist circumference, body mass index and ratio of waist circumference to height were measured. Serum levels of fibroblast growth factor-23 and dephosphorylated and non-carboxylated protein matrix gamma carboxyglutamate were measured and glomerular filtration rate was calculated as an index of kidney function. Collected data were analyzed using Kolmogorov-Smirnov, Pearson and Spearman statistical tests.
Results: The mean and standard deviation of the age of the subjects was 44.10±13.05 years and 59% of the patients were male. Mean ± standard deviation of weight, body mass index, waist circumference and ratio of waist circumference to height of the patients were 69.61±11.59 kg, 25.77±4.42 kg/m2, 94.07±15.48 cm and respectively. It was 0.58±0.11. The prevalence of overweight and obesity based on body mass index was 38% and 17%, respectively. The mean ± standard deviation of the glomerular filtration rate is 57.45±12.61 ml/min per 1.73 square meter and the serum level of fibroblast growth factor-23 is 73.63±20.9 units/ml and the median (25th percentile) and the 75th percentile) the dephosphorylated and non-carboxylated protein gamma carboxy glutamate matrix of serum was also (1.3, 60.20) 2.40 micrograms/liter. Significant correlation between anthropometric indices with glomerular filtration rate and serum levels of fibroblast growth factor-23 and matrix gamma carboxy glutamate dephosphorylated and non-carboxylated protein, as well as between glomerular filtration rate and serum levels of fibroblast growth factor-23 and matrix gamma carboxy glutamate dephosphorylated protein and Non-carboxylated was not observed (p>0.05). A significant inverse correlation was observed between serum levels of fibroblast growth factor-23 and dephosphorylated and non-carboxylated protein gamma-carboxyglutamate matrix (p=0.036).
Conclusion: Considering that in the present study, the average weight, body mass index and also the performance of all patients were almost within the normal range, therefore, there is a significant relationship between anthropometric indices with glomerular filtration rate and serum levels of fibroblast growth factor-23 and gamma carboxy matrix. Dephosphorylated and non-carboxylated protein glutamate was not observed. |
| first_indexed | 2024-03-11T18:55:32Z |
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| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-03-11T18:55:32Z |
| publishDate | 2022-08-01 |
| publisher | Yasuj University Of Medical Sciences |
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| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-5ae2669e9ce348a69bb3880a04e63c4f2023-10-11T04:43:16ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142022-08-01275564577Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant PatientsV Ebrahimzadeh Attari0MR Ardalan1S Abedi Azar2J Etemadi3A Malik Mahdavi4A Madah5 Department of Nutrition and Food Industry, Maragheh School of Medical Sciences, Maragheh, Iran, Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Background & aim: Considering that overweight and obesity in transplant patients are considered as a risk factor for the occurrence of metabolic disorders, heart diseases and reduced kidney function, therefore, the purpose of the present study was to determine and investigate the relationship between anthropometric indicators and kidney function. In addition, the serum levels of fibroblast growth factor-23 and matrix gamma carboxyglutamate protein were markers of cardiovascular disease risk in kidney transplant patients. Methods: The present study was conducted as a cross-sectional study in 2016-2019. Ninety kidney transplant patients referred to Tabriz Imam Reza (AS) hospital clinic, between 18 and 70 years of age and had normal kidney function and were within 6-12 months after transplant, were selected. Weight, height, waist circumference, body mass index and ratio of waist circumference to height were measured. Serum levels of fibroblast growth factor-23 and dephosphorylated and non-carboxylated protein matrix gamma carboxyglutamate were measured and glomerular filtration rate was calculated as an index of kidney function. Collected data were analyzed using Kolmogorov-Smirnov, Pearson and Spearman statistical tests. Results: The mean and standard deviation of the age of the subjects was 44.10±13.05 years and 59% of the patients were male. Mean ± standard deviation of weight, body mass index, waist circumference and ratio of waist circumference to height of the patients were 69.61±11.59 kg, 25.77±4.42 kg/m2, 94.07±15.48 cm and respectively. It was 0.58±0.11. The prevalence of overweight and obesity based on body mass index was 38% and 17%, respectively. The mean ± standard deviation of the glomerular filtration rate is 57.45±12.61 ml/min per 1.73 square meter and the serum level of fibroblast growth factor-23 is 73.63±20.9 units/ml and the median (25th percentile) and the 75th percentile) the dephosphorylated and non-carboxylated protein gamma carboxy glutamate matrix of serum was also (1.3, 60.20) 2.40 micrograms/liter. Significant correlation between anthropometric indices with glomerular filtration rate and serum levels of fibroblast growth factor-23 and matrix gamma carboxy glutamate dephosphorylated and non-carboxylated protein, as well as between glomerular filtration rate and serum levels of fibroblast growth factor-23 and matrix gamma carboxy glutamate dephosphorylated protein and Non-carboxylated was not observed (p>0.05). A significant inverse correlation was observed between serum levels of fibroblast growth factor-23 and dephosphorylated and non-carboxylated protein gamma-carboxyglutamate matrix (p=0.036). Conclusion: Considering that in the present study, the average weight, body mass index and also the performance of all patients were almost within the normal range, therefore, there is a significant relationship between anthropometric indices with glomerular filtration rate and serum levels of fibroblast growth factor-23 and gamma carboxy matrix. Dephosphorylated and non-carboxylated protein glutamate was not observed.http://armaghanj.yums.ac.ir/article-1-3282-en.pdf anthropometric indicesweightbody mass indexkidney functionfibroblast growth factor-23matrix gamma carboxyglutamate proteinkidney transplant |
| spellingShingle | V Ebrahimzadeh Attari MR Ardalan S Abedi Azar J Etemadi A Malik Mahdavi A Madah Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients Armaghane Danesh Bimonthly Journal anthropometric indices weight body mass index kidney function fibroblast growth factor-23 matrix gamma carboxyglutamate protein kidney transplant |
| title | Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients |
| title_full | Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients |
| title_fullStr | Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients |
| title_full_unstemmed | Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients |
| title_short | Investigating the Relationship of Anthropometric Indices with Kidney Function and Serum Levels of Fibroblast Growth Factor-23 and Matrix Gamma Carboxyglutamate Protein in Kidney Transplant Patients |
| title_sort | investigating the relationship of anthropometric indices with kidney function and serum levels of fibroblast growth factor 23 and matrix gamma carboxyglutamate protein in kidney transplant patients |
| topic | anthropometric indices weight body mass index kidney function fibroblast growth factor-23 matrix gamma carboxyglutamate protein kidney transplant |
| url | http://armaghanj.yums.ac.ir/article-1-3282-en.pdf |
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