Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review
Abstract Background Capecitabine (Xeloda®) is a cytotoxic, antimetabolite chemotherapeutic agent. Its most common adverse events are diarrhea, hand-foot syndrome (HFS), hyperbilirubinemia, hyperpigmentation, fatigue, abdominal pain, and other gastrointestinal effects. HFS or palmar-plantar erythrod...
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| Materiálatiipa: | Artihkal |
| Giella: | English |
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Sociedade Brasileira de Dermatologia
2023-06-01
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| Ráidu: | Anais Brasileiros de Dermatologia |
| Fáttát: | |
| Liŋkkat: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000300302&tlng=en |
| _version_ | 1827912671349964800 |
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| author | Anna Danielly Almeida do Nascimento Débora Maria Porto Aurora Karla de Lacerda Vidal |
| author_facet | Anna Danielly Almeida do Nascimento Débora Maria Porto Aurora Karla de Lacerda Vidal |
| author_sort | Anna Danielly Almeida do Nascimento |
| collection | DOAJ |
| description | Abstract Background Capecitabine (Xeloda®) is a cytotoxic, antimetabolite chemotherapeutic agent. Its most common adverse events are diarrhea, hand-foot syndrome (HFS), hyperbilirubinemia, hyperpigmentation, fatigue, abdominal pain, and other gastrointestinal effects. HFS or palmar-plantar erythrodysesthesia (PPE) is an adverse reaction resulting from therapy with chemotherapeutic agents, classified into three degrees. Hyperpigmentation, as an adverse effect of capecitabine, can occur in different locations and with different patterns. The skin, nails and oral mucosal membrane can be affected. Objective The objective of this study was to report and discuss oral hyperpigmentation associated with HFS caused by the use of capecitabine, which is still poorly described in the literature. Methodology A literature review was carried out using the online databases PubMed, Scielo, BVS, Lilacs, Medline, BBO and Google Scholar, associating the descriptors “Capecitabine”, “Pigmentation Disorders”, “Oral mucosa”, “Cancer” and “Hand-Foot Syndrome”, which were related and used to exemplify, discuss and report the exposed clinical case. Results This case report corroborates the literature regarding the incidence in females and black skin persons like this patient who was affected by HFS when undergoing antineoplastic therapy with capecitabine and presented hyperpigmentation of the hands, feet and oral mucosa. On the oral mucosa, the hyperpigmented spots were diffuse, showing a blackish color and irregular edges. Their pathophysiology remains unknown. Study limitations Few articles citing capecitabine-associated pigmentation. Conclusions It is hoped that this study may contribute to the identification and correct diagnosis of hyperpigmentation in the oral cavity, as well as call attention to the adverse effects related to capecitabine. |
| first_indexed | 2024-03-13T02:18:56Z |
| format | Article |
| id | doaj.art-5ae432f80f0445e3ab1b60bbbfec0f4c |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-03-13T02:18:56Z |
| publishDate | 2023-06-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-5ae432f80f0445e3ab1b60bbbfec0f4c2023-06-30T10:50:24ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962023-06-0198330230910.1016/j.abd.2022.05.004Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature reviewAnna Danielly Almeida do Nascimentohttps://orcid.org/0000-0002-4424-1039Débora Maria Portohttps://orcid.org/0000-0002-4937-2441Aurora Karla de Lacerda Vidalhttps://orcid.org/0000-0003-2831-2471Abstract Background Capecitabine (Xeloda®) is a cytotoxic, antimetabolite chemotherapeutic agent. Its most common adverse events are diarrhea, hand-foot syndrome (HFS), hyperbilirubinemia, hyperpigmentation, fatigue, abdominal pain, and other gastrointestinal effects. HFS or palmar-plantar erythrodysesthesia (PPE) is an adverse reaction resulting from therapy with chemotherapeutic agents, classified into three degrees. Hyperpigmentation, as an adverse effect of capecitabine, can occur in different locations and with different patterns. The skin, nails and oral mucosal membrane can be affected. Objective The objective of this study was to report and discuss oral hyperpigmentation associated with HFS caused by the use of capecitabine, which is still poorly described in the literature. Methodology A literature review was carried out using the online databases PubMed, Scielo, BVS, Lilacs, Medline, BBO and Google Scholar, associating the descriptors “Capecitabine”, “Pigmentation Disorders”, “Oral mucosa”, “Cancer” and “Hand-Foot Syndrome”, which were related and used to exemplify, discuss and report the exposed clinical case. Results This case report corroborates the literature regarding the incidence in females and black skin persons like this patient who was affected by HFS when undergoing antineoplastic therapy with capecitabine and presented hyperpigmentation of the hands, feet and oral mucosa. On the oral mucosa, the hyperpigmented spots were diffuse, showing a blackish color and irregular edges. Their pathophysiology remains unknown. Study limitations Few articles citing capecitabine-associated pigmentation. Conclusions It is hoped that this study may contribute to the identification and correct diagnosis of hyperpigmentation in the oral cavity, as well as call attention to the adverse effects related to capecitabine.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000300302&tlng=enCancerCapecitabineHand-foot syndromeOral mucosaPigmentation disorders |
| spellingShingle | Anna Danielly Almeida do Nascimento Débora Maria Porto Aurora Karla de Lacerda Vidal Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review Anais Brasileiros de Dermatologia Cancer Capecitabine Hand-foot syndrome Oral mucosa Pigmentation disorders |
| title | Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review |
| title_full | Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review |
| title_fullStr | Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review |
| title_full_unstemmed | Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review |
| title_short | Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review |
| title_sort | capecitabine induced oral mucosal hyperpigmentation associated with hand foot syndrome a literature review |
| topic | Cancer Capecitabine Hand-foot syndrome Oral mucosa Pigmentation disorders |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962023000300302&tlng=en |
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