Association of Lupus Anticoagulant status with Disease Course in SARS-CoV-2 (COVID-19) Infection
Background: We investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. Methods: Medical records of 41 SARS-CoV-2 infected patients were reviewed. Patients were classified into two groups according to the frequency of positive LA test results: “LA (−)” and “LA (+) ≥1” (LA...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-09-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221127276 |
| _version_ | 1818029789938712576 |
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| author | Suhyeon Woo MD Bohyun Kim MD, PhD Nam Hun Heo MS Min-sun Kim MD Young Ahn Yoon MD Young-Jin Choi MD, PhD |
| author_facet | Suhyeon Woo MD Bohyun Kim MD, PhD Nam Hun Heo MS Min-sun Kim MD Young Ahn Yoon MD Young-Jin Choi MD, PhD |
| author_sort | Suhyeon Woo MD |
| collection | DOAJ |
| description | Background: We investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. Methods: Medical records of 41 SARS-CoV-2 infected patients were reviewed. Patients were classified into two groups according to the frequency of positive LA test results: “LA (−)” and “LA (+) ≥1” (LA positive at least once). Statistical analysis was performed to determine the association between LA presence and change in LA test results and disease course according to both hospital days (HD) and days after diagnosis (DD). Results: The prevalence of LA was 51.2%. Averagely, the first change in LA test result occurred during DD 12-13 and between HD 9-10. The second change occurred on DD 15-16 and HD 13-14. The presence of LA was associated with severe disease ( P = .004) but was not associated with thrombotic complications or mortality. The change of results from negative to positive or vice versa or the frequency of the changes was not associated with disease severity, thrombotic complications, or mortality. Conclusions: LA positivity can be regarded as one of the findings suggesting more serious SARS-CoV-2 infection. |
| first_indexed | 2024-12-10T05:25:17Z |
| format | Article |
| id | doaj.art-5ae4a1ddc1854390a478042800b8e81d |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-10T05:25:17Z |
| publishDate | 2022-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-5ae4a1ddc1854390a478042800b8e81d2022-12-22T02:00:42ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-09-012810.1177/10760296221127276Association of Lupus Anticoagulant status with Disease Course in SARS-CoV-2 (COVID-19) InfectionSuhyeon Woo MD0Bohyun Kim MD, PhD1Nam Hun Heo MS2Min-sun Kim MD3Young Ahn Yoon MD4Young-Jin Choi MD, PhD5 Department of Laboratory Medicine, , Soonchunhyang University College of Medicine, Cheonan, Korea Department of Laboratory Medicine, , Soonchunhyang University College of Medicine, Cheonan, Korea Clinical Trial Center, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea Department of Laboratory Medicine, , Soonchunhyang University College of Medicine, Cheonan, Korea Department of Laboratory Medicine, , Soonchunhyang University College of Medicine, Cheonan, Korea Department of Laboratory Medicine, , Soonchunhyang University College of Medicine, Cheonan, KoreaBackground: We investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. Methods: Medical records of 41 SARS-CoV-2 infected patients were reviewed. Patients were classified into two groups according to the frequency of positive LA test results: “LA (−)” and “LA (+) ≥1” (LA positive at least once). Statistical analysis was performed to determine the association between LA presence and change in LA test results and disease course according to both hospital days (HD) and days after diagnosis (DD). Results: The prevalence of LA was 51.2%. Averagely, the first change in LA test result occurred during DD 12-13 and between HD 9-10. The second change occurred on DD 15-16 and HD 13-14. The presence of LA was associated with severe disease ( P = .004) but was not associated with thrombotic complications or mortality. The change of results from negative to positive or vice versa or the frequency of the changes was not associated with disease severity, thrombotic complications, or mortality. Conclusions: LA positivity can be regarded as one of the findings suggesting more serious SARS-CoV-2 infection.https://doi.org/10.1177/10760296221127276 |
| spellingShingle | Suhyeon Woo MD Bohyun Kim MD, PhD Nam Hun Heo MS Min-sun Kim MD Young Ahn Yoon MD Young-Jin Choi MD, PhD Association of Lupus Anticoagulant status with Disease Course in SARS-CoV-2 (COVID-19) Infection Clinical and Applied Thrombosis/Hemostasis |
| title | Association of Lupus Anticoagulant status
with Disease Course in SARS-CoV-2
(COVID-19) Infection |
| title_full | Association of Lupus Anticoagulant status
with Disease Course in SARS-CoV-2
(COVID-19) Infection |
| title_fullStr | Association of Lupus Anticoagulant status
with Disease Course in SARS-CoV-2
(COVID-19) Infection |
| title_full_unstemmed | Association of Lupus Anticoagulant status
with Disease Course in SARS-CoV-2
(COVID-19) Infection |
| title_short | Association of Lupus Anticoagulant status
with Disease Course in SARS-CoV-2
(COVID-19) Infection |
| title_sort | association of lupus anticoagulant status with disease course in sars cov 2 covid 19 infection |
| url | https://doi.org/10.1177/10760296221127276 |
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