Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis
Abstract Background Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1326-x |
| _version_ | 1811220985441943552 |
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| author | Naren Kumar Surendra Mohd Rizal Abdul Manaf Lai Seong Hooi Sunita Bavanandan Fariz Safhan Mohamad Nor Shahnaz Shah Firdaus Khan Loke Meng Ong Abdul Halim Abdul Gafor |
| author_facet | Naren Kumar Surendra Mohd Rizal Abdul Manaf Lai Seong Hooi Sunita Bavanandan Fariz Safhan Mohamad Nor Shahnaz Shah Firdaus Khan Loke Meng Ong Abdul Halim Abdul Gafor |
| author_sort | Naren Kumar Surendra |
| collection | DOAJ |
| description | Abstract Background Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify socio-demographic and clinical factors associated with HRQOL for haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Malaysia. Methods A total of 141 patients (77 HD and 64 CAPD) from 1 federal and four state hospitals participated in this cross-sectional study. Patients were randomly selected from the National Renal Registry (NRR) using a stratified random sampling. The EQ-5D-3 L questionnaire was used to measure HRQOL. Variables investigated include dialysis modalities, sociodemographic characteristics, co-morbidities and biochemical markers. Utilities are measured on an ordinal scale of 0–1, where 1 indicates full health and 0 indicates death. Results The mean utility scores were 0.854 ± 0.181 and 0.905 ± 0.124 (p > 0.05) and the mean Visual Analogue Scale (VAS) scores were 76.2 ± 12.90 and 77.1 ± 10.26 (p > 0.05) for HD and CAPD patients respectively. There was a significant difference in problems reported between HD (35.1%) and CAPD (15.6%) on usual activities dimension (p = 0.009). The proportion of patients having problems in the pain/discomfort domain in both modalities was high (34.0%). Haemoglobin (< 10 g/dL) (p = 0.003), number of co-morbidities ≥3 (p = 0.004) and wheelchair-bound status (p < 0.001) were significant predictors of poor HRQOL. Conclusions The present cross-sectional study shows that CAPD patients have a higher utility index score than HD patients but this was not statistically significant. The utilities index score may be used to calculate QALYs. |
| first_indexed | 2024-04-12T07:51:07Z |
| format | Article |
| id | doaj.art-5ae6f4277acc4a0aafab1366bbdf45f4 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-12T07:51:07Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-5ae6f4277acc4a0aafab1366bbdf45f42022-12-22T03:41:35ZengBMCBMC Nephrology1471-23692019-04-0120111010.1186/s12882-019-1326-xHealth related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysisNaren Kumar Surendra0Mohd Rizal Abdul Manaf1Lai Seong Hooi2Sunita Bavanandan3Fariz Safhan Mohamad Nor4Shahnaz Shah Firdaus Khan5Loke Meng Ong6Abdul Halim Abdul Gafor7Department of Community Health, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan MalaysiaDepartment of Community Health, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan MalaysiaHospital Sultanah AminahHospital Kuala LumpurHospital Tengku Ampuan AfzanHospital Tengku Ampuan RahimahHospital Pulau PinangNephrology Unit, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan MalaysiaAbstract Background Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation studies. This study aims to measure the health utilities and to identify socio-demographic and clinical factors associated with HRQOL for haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) in Malaysia. Methods A total of 141 patients (77 HD and 64 CAPD) from 1 federal and four state hospitals participated in this cross-sectional study. Patients were randomly selected from the National Renal Registry (NRR) using a stratified random sampling. The EQ-5D-3 L questionnaire was used to measure HRQOL. Variables investigated include dialysis modalities, sociodemographic characteristics, co-morbidities and biochemical markers. Utilities are measured on an ordinal scale of 0–1, where 1 indicates full health and 0 indicates death. Results The mean utility scores were 0.854 ± 0.181 and 0.905 ± 0.124 (p > 0.05) and the mean Visual Analogue Scale (VAS) scores were 76.2 ± 12.90 and 77.1 ± 10.26 (p > 0.05) for HD and CAPD patients respectively. There was a significant difference in problems reported between HD (35.1%) and CAPD (15.6%) on usual activities dimension (p = 0.009). The proportion of patients having problems in the pain/discomfort domain in both modalities was high (34.0%). Haemoglobin (< 10 g/dL) (p = 0.003), number of co-morbidities ≥3 (p = 0.004) and wheelchair-bound status (p < 0.001) were significant predictors of poor HRQOL. Conclusions The present cross-sectional study shows that CAPD patients have a higher utility index score than HD patients but this was not statistically significant. The utilities index score may be used to calculate QALYs.http://link.springer.com/article/10.1186/s12882-019-1326-xDialysisContinuous ambulatory peritoneal dialysisEQ-5DHaemodialysisMalaysiaQuality adjusted life year |
| spellingShingle | Naren Kumar Surendra Mohd Rizal Abdul Manaf Lai Seong Hooi Sunita Bavanandan Fariz Safhan Mohamad Nor Shahnaz Shah Firdaus Khan Loke Meng Ong Abdul Halim Abdul Gafor Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis BMC Nephrology Dialysis Continuous ambulatory peritoneal dialysis EQ-5D Haemodialysis Malaysia Quality adjusted life year |
| title | Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis |
| title_full | Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis |
| title_fullStr | Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis |
| title_full_unstemmed | Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis |
| title_short | Health related quality of life of dialysis patients in Malaysia: Haemodialysis versus continuous ambulatory peritoneal dialysis |
| title_sort | health related quality of life of dialysis patients in malaysia haemodialysis versus continuous ambulatory peritoneal dialysis |
| topic | Dialysis Continuous ambulatory peritoneal dialysis EQ-5D Haemodialysis Malaysia Quality adjusted life year |
| url | http://link.springer.com/article/10.1186/s12882-019-1326-x |
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