Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital
Background: Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective: This study aimed to evaluate the hepatic effect of d...
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| Format: | Article |
| Language: | English |
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Knowledge E
2017-04-01
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| Series: | Sudan Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/sjms.v12i3.937 |
| _version_ | 1818955966618533888 |
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| author | Bashir Abdrhman Bashir Mohammed |
| author_facet | Bashir Abdrhman Bashir Mohammed |
| author_sort | Bashir Abdrhman Bashir Mohammed |
| collection | DOAJ |
| description | Background: Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective: This study aimed to evaluate the hepatic effect of dengue fever amongst Sudanese patients. Materials and Methods: A cross-sectional descriptive study recruited in Port Sudan teaching hospital in the period from February 2013 to June 2014. 334 cases of dengue along with 101 cases of control were enrolled. The rapid immune chromatographies test was used to confirm positive dengue cases and WHO criteria were used for classifying the dengue severity. Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level (FB), platelet count (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) were all measured. Results: PT, PTT, and FB were found to be significantly higher in the infected cohort when compared to the controls (P < 0.0001). PT was prolonged in 9%, PTT was prolonged in 12.6% and shortened by 5.4% of the patients, whereas hypofibrinogenemia in 18.3% and hyperfibrinogenemia in 67.4% of the patients. Bleeding was seen in 10.5% of patients and thrombocytopenia was detected in 83.5% of patients. Out of 334 patients, 101 (30.2%) had abnormal coagulation results. Of 101 patients, 72 were subjected mixing studies for PT and PTT that revealed deficiencies in factors VIII (35%), IX (10%), V (10%), X (19%), and XII (14%). 43.6% patients had elevated AST and 21.8% had elevated ALT. Conclusion: This study demonstrated that hepatic dysfunction may be attributed to dengue virus infection which evident by prolongation in PT and PTT as well as hypofibrinogenemia and factor deficiencies. |
| first_indexed | 2024-12-20T10:46:28Z |
| format | Article |
| id | doaj.art-5ae73113d6ed4890b993412ddc483612 |
| institution | Directory Open Access Journal |
| issn | 1858-5051 |
| language | English |
| last_indexed | 2024-12-20T10:46:28Z |
| publishDate | 2017-04-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Sudan Journal of Medical Sciences |
| spelling | doaj.art-5ae73113d6ed4890b993412ddc4836122022-12-21T19:43:22ZengKnowledge ESudan Journal of Medical Sciences1858-50512017-04-01201711110.18502/sjms.v12i3.937sjms.v12i3.937Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching HospitalBashir Abdrhman Bashir Mohammed0Assistant Professor of Hematology, Chairman of Hematology Department, Medical Laboratory Sciences Division, Port Sudan Ahlia College, Port Sudan, SudanBackground: Deranged liver is a well-recognized feature of dengue infection, often demonstrated by coagulopathy and mild to moderate increase in transaminase levels although jaundice and fulminant hepatic failure are generally uncommon. Objective: This study aimed to evaluate the hepatic effect of dengue fever amongst Sudanese patients. Materials and Methods: A cross-sectional descriptive study recruited in Port Sudan teaching hospital in the period from February 2013 to June 2014. 334 cases of dengue along with 101 cases of control were enrolled. The rapid immune chromatographies test was used to confirm positive dengue cases and WHO criteria were used for classifying the dengue severity. Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen level (FB), platelet count (PLT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and C-reactive protein (CRP) were all measured. Results: PT, PTT, and FB were found to be significantly higher in the infected cohort when compared to the controls (P < 0.0001). PT was prolonged in 9%, PTT was prolonged in 12.6% and shortened by 5.4% of the patients, whereas hypofibrinogenemia in 18.3% and hyperfibrinogenemia in 67.4% of the patients. Bleeding was seen in 10.5% of patients and thrombocytopenia was detected in 83.5% of patients. Out of 334 patients, 101 (30.2%) had abnormal coagulation results. Of 101 patients, 72 were subjected mixing studies for PT and PTT that revealed deficiencies in factors VIII (35%), IX (10%), V (10%), X (19%), and XII (14%). 43.6% patients had elevated AST and 21.8% had elevated ALT. Conclusion: This study demonstrated that hepatic dysfunction may be attributed to dengue virus infection which evident by prolongation in PT and PTT as well as hypofibrinogenemia and factor deficiencies.https://doi.org/10.18502/sjms.v12i3.937Deranged liver, Dengue, DHF, Coagulation factors, Sudan |
| spellingShingle | Bashir Abdrhman Bashir Mohammed Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital Sudan Journal of Medical Sciences Deranged liver, Dengue, DHF, Coagulation factors, Sudan |
| title | Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital |
| title_full | Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital |
| title_fullStr | Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital |
| title_full_unstemmed | Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital |
| title_short | Deranged liver among Sudanese Patients with Dengue Virus Infection in Port Sudan Teaching Hospital |
| title_sort | deranged liver among sudanese patients with dengue virus infection in port sudan teaching hospital |
| topic | Deranged liver, Dengue, DHF, Coagulation factors, Sudan |
| url | https://doi.org/10.18502/sjms.v12i3.937 |
| work_keys_str_mv | AT bashirabdrhmanbashirmohammed derangedliveramongsudanesepatientswithdenguevirusinfectioninportsudanteachinghospital |