Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Modelling of the SDF-1/CXCR4 regulated in vivo homing of therapeutic mesenchymal stem/stromal cells in mice

Background Mesenchymal stem/stromal cells (MSCs) are a promising tool for cell-based therapies in the treatment of tissue injury. The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a significant role in directing MSC homing to sites of injury. However in vivo MSC d...

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Bibliographic Details
Main Authors:	Wang Jin, Xiaowen Liang, Anastasia Brooks, Kathryn Futrega, Xin Liu, Michael R. Doran, Matthew J. Simpson, Michael S. Roberts, Haolu Wang
Format:	Article
Language:	English
Published:	PeerJ Inc. 2018-12-01
Series:	PeerJ
Subjects:	Mesenchymal stem cells Stem cell transplantation Chemotaxis Mathematical modelling In vivo homing
Online Access:	https://peerj.com/articles/6072.pdf

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