The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review
New approaches to managing infections in cardiac and peripheral vascular surgery are required to reduce costs to patients and healthcare providers. Bacteriophage (phage) therapy is a promising antimicrobial approach that has been recommended for consideration in antibiotic refractory cases. We syste...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/12/1684 |
| _version_ | 1827575898755301376 |
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| author | Emily A. Simpson Caitlin S. MacLeod Helen J. Stacey John Nagy Joshua D. Jones |
| author_facet | Emily A. Simpson Caitlin S. MacLeod Helen J. Stacey John Nagy Joshua D. Jones |
| author_sort | Emily A. Simpson |
| collection | DOAJ |
| description | New approaches to managing infections in cardiac and peripheral vascular surgery are required to reduce costs to patients and healthcare providers. Bacteriophage (phage) therapy is a promising antimicrobial approach that has been recommended for consideration in antibiotic refractory cases. We systematically reviewed the clinical evidence for phage therapy in vascular surgery to support the unlicensed use of phage therapy and inform future research. Three electronic databases were searched for articles that reported primary data about human phage therapy for infections in cardiac or peripheral vascular surgery. Fourteen reports were eligible for inclusion, representing 40 patients, among which an estimated 70.3% of patients (n = 26/37) achieved clinical resolution. A further 10.8% (n = 4/37) of patients showed improvement and 18.9% (n = 7/37) showed no improvement. Six of the twelve reports that commented on the safety of phage therapy did not report adverse effects. No adverse effects documented in the remaining six reports were directly linked to phages but reflected the presence of manufacturing contaminants or release of bacterial debris following bacterial lysis. The reports identified by this review suggest that appropriately purified phages represent a safe and efficacious treatment option for infections in cardiac and peripheral vascular surgery. |
| first_indexed | 2024-03-08T21:03:29Z |
| format | Article |
| id | doaj.art-5ae9734c7f694f68b363466a883f04f0 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-08T21:03:29Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5ae9734c7f694f68b363466a883f04f02023-12-22T13:47:53ZengMDPI AGAntibiotics2079-63822023-11-011212168410.3390/antibiotics12121684The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic ReviewEmily A. Simpson0Caitlin S. MacLeod1Helen J. Stacey2John Nagy3Joshua D. Jones4Medical Microbiology, Ninewells Hospital, NHS Tayside, Dundee DD2 1SG, UKDepartment of Vascular Surgery, Ninewells Hospital, NHS Tayside, Dundee DD2 1SG, UKPublic Health, Kings Cross Hospital, Clepington Road, NHS Tayside, Dundee DD3 8EA, UKDepartment of Vascular Surgery, Ninewells Hospital, NHS Tayside, Dundee DD2 1SG, UKMedical Microbiology, Ninewells Hospital, NHS Tayside, Dundee DD2 1SG, UKNew approaches to managing infections in cardiac and peripheral vascular surgery are required to reduce costs to patients and healthcare providers. Bacteriophage (phage) therapy is a promising antimicrobial approach that has been recommended for consideration in antibiotic refractory cases. We systematically reviewed the clinical evidence for phage therapy in vascular surgery to support the unlicensed use of phage therapy and inform future research. Three electronic databases were searched for articles that reported primary data about human phage therapy for infections in cardiac or peripheral vascular surgery. Fourteen reports were eligible for inclusion, representing 40 patients, among which an estimated 70.3% of patients (n = 26/37) achieved clinical resolution. A further 10.8% (n = 4/37) of patients showed improvement and 18.9% (n = 7/37) showed no improvement. Six of the twelve reports that commented on the safety of phage therapy did not report adverse effects. No adverse effects documented in the remaining six reports were directly linked to phages but reflected the presence of manufacturing contaminants or release of bacterial debris following bacterial lysis. The reports identified by this review suggest that appropriately purified phages represent a safe and efficacious treatment option for infections in cardiac and peripheral vascular surgery.https://www.mdpi.com/2079-6382/12/12/1684bacteriophagecardiac surgeryperipheral vascular surgeryphage therapysystematic review |
| spellingShingle | Emily A. Simpson Caitlin S. MacLeod Helen J. Stacey John Nagy Joshua D. Jones The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review Antibiotics bacteriophage cardiac surgery peripheral vascular surgery phage therapy systematic review |
| title | The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review |
| title_full | The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review |
| title_fullStr | The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review |
| title_full_unstemmed | The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review |
| title_short | The Safety and Efficacy of Phage Therapy for Infections in Cardiac and Peripheral Vascular Surgery: A Systematic Review |
| title_sort | safety and efficacy of phage therapy for infections in cardiac and peripheral vascular surgery a systematic review |
| topic | bacteriophage cardiac surgery peripheral vascular surgery phage therapy systematic review |
| url | https://www.mdpi.com/2079-6382/12/12/1684 |
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