Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era

Acute otitis media (AOM) is a leading cause of antibiotic prescriptions in children worldwide, even in the era of pneumococcal conjugate vaccines. We aimed to assess the bacterial spectrum of AOM in children and to investigate the antimicrobial resistance profile in culture-positive cases. We perfor...

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Bibliographic Details
Main Authors: Cristina Gavrilovici, Elena-Lia Spoială, Ingrith-Crenguţa Miron, Iuliana Magdalena Stârcea, Codruţa Olimpiada Iliescu Haliţchi, Irina Nicoleta Zetu, Vasile Valeriu Lupu, Carmen Pânzaru
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Microorganisms
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Online Access:https://www.mdpi.com/2076-2607/10/8/1598
Description
Summary:Acute otitis media (AOM) is a leading cause of antibiotic prescriptions in children worldwide, even in the era of pneumococcal conjugate vaccines. We aimed to assess the bacterial spectrum of AOM in children and to investigate the antimicrobial resistance profile in culture-positive cases. We performed a retrospective, tympanocentesis-based analysis of antimicrobial resistance patterns in children with AOM hospitalized in “St Mary” Emergency Hospital for Children Iasi, Romania, between January 2013 and December 2021. A total of 147 samples have been assessed, 97 (65.98%) of which had positive cultures, with <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> as the most common microorganisms. A worrying proportion, 82.85% (58/70), of the <i>Streptococcus pneumoniae</i> strains were multidrug-resistant. The World Health Organization included <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> on the medium priority group due to penicillin non-susceptibility and ampicillin-resistant strains, respectively. Consequently, strategies to address the threats of antimicrobial resistance are needed to reduce the potential negative effects on hospitalization costs.
ISSN:2076-2607