Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era
Acute otitis media (AOM) is a leading cause of antibiotic prescriptions in children worldwide, even in the era of pneumococcal conjugate vaccines. We aimed to assess the bacterial spectrum of AOM in children and to investigate the antimicrobial resistance profile in culture-positive cases. We perfor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/8/1598 |
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| author | Cristina Gavrilovici Elena-Lia Spoială Ingrith-Crenguţa Miron Iuliana Magdalena Stârcea Codruţa Olimpiada Iliescu Haliţchi Irina Nicoleta Zetu Vasile Valeriu Lupu Carmen Pânzaru |
| author_facet | Cristina Gavrilovici Elena-Lia Spoială Ingrith-Crenguţa Miron Iuliana Magdalena Stârcea Codruţa Olimpiada Iliescu Haliţchi Irina Nicoleta Zetu Vasile Valeriu Lupu Carmen Pânzaru |
| author_sort | Cristina Gavrilovici |
| collection | DOAJ |
| description | Acute otitis media (AOM) is a leading cause of antibiotic prescriptions in children worldwide, even in the era of pneumococcal conjugate vaccines. We aimed to assess the bacterial spectrum of AOM in children and to investigate the antimicrobial resistance profile in culture-positive cases. We performed a retrospective, tympanocentesis-based analysis of antimicrobial resistance patterns in children with AOM hospitalized in “St Mary” Emergency Hospital for Children Iasi, Romania, between January 2013 and December 2021. A total of 147 samples have been assessed, 97 (65.98%) of which had positive cultures, with <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> as the most common microorganisms. A worrying proportion, 82.85% (58/70), of the <i>Streptococcus pneumoniae</i> strains were multidrug-resistant. The World Health Organization included <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> on the medium priority group due to penicillin non-susceptibility and ampicillin-resistant strains, respectively. Consequently, strategies to address the threats of antimicrobial resistance are needed to reduce the potential negative effects on hospitalization costs. |
| first_indexed | 2024-03-09T09:51:53Z |
| format | Article |
| id | doaj.art-5ae97ad3a128434f9210201691561a5c |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T09:51:53Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-5ae97ad3a128434f9210201691561a5c2023-12-02T00:02:38ZengMDPI AGMicroorganisms2076-26072022-08-01108159810.3390/microorganisms10081598Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination EraCristina Gavrilovici0Elena-Lia Spoială1Ingrith-Crenguţa Miron2Iuliana Magdalena Stârcea3Codruţa Olimpiada Iliescu Haliţchi4Irina Nicoleta Zetu5Vasile Valeriu Lupu6Carmen Pânzaru7Department of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Orthodontics and Dento-Facial Orthopedics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, RomaniaDepartment of Pediatrics, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania“St Mary” Emergency Hospital for Children, 700309 Iasi, RomaniaAcute otitis media (AOM) is a leading cause of antibiotic prescriptions in children worldwide, even in the era of pneumococcal conjugate vaccines. We aimed to assess the bacterial spectrum of AOM in children and to investigate the antimicrobial resistance profile in culture-positive cases. We performed a retrospective, tympanocentesis-based analysis of antimicrobial resistance patterns in children with AOM hospitalized in “St Mary” Emergency Hospital for Children Iasi, Romania, between January 2013 and December 2021. A total of 147 samples have been assessed, 97 (65.98%) of which had positive cultures, with <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> as the most common microorganisms. A worrying proportion, 82.85% (58/70), of the <i>Streptococcus pneumoniae</i> strains were multidrug-resistant. The World Health Organization included <i>Streptococcus pneumoniae</i> and <i>Haemophilus influenzae</i> on the medium priority group due to penicillin non-susceptibility and ampicillin-resistant strains, respectively. Consequently, strategies to address the threats of antimicrobial resistance are needed to reduce the potential negative effects on hospitalization costs.https://www.mdpi.com/2076-2607/10/8/1598acute otitis mediatympanocentesis<i>Streptococcus pneumoniae</i>antibiotic resistancechildren |
| spellingShingle | Cristina Gavrilovici Elena-Lia Spoială Ingrith-Crenguţa Miron Iuliana Magdalena Stârcea Codruţa Olimpiada Iliescu Haliţchi Irina Nicoleta Zetu Vasile Valeriu Lupu Carmen Pânzaru Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era Microorganisms acute otitis media tympanocentesis <i>Streptococcus pneumoniae</i> antibiotic resistance children |
| title | Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era |
| title_full | Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era |
| title_fullStr | Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era |
| title_full_unstemmed | Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era |
| title_short | Acute Otitis Media in Children—Challenges of Antibiotic Resistance in the Post-Vaccination Era |
| title_sort | acute otitis media in children challenges of antibiotic resistance in the post vaccination era |
| topic | acute otitis media tympanocentesis <i>Streptococcus pneumoniae</i> antibiotic resistance children |
| url | https://www.mdpi.com/2076-2607/10/8/1598 |
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