Phenotypic differences between highlanders and lowlanders in Papua New Guinea.
<h4>Objectives</h4>Altitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock et al., 1972; Cotes et al....
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0253921 |
| _version_ | 1818404596683374592 |
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| author | Mathilde André Nicolas Brucato Sébastien Plutniak Jason Kariwiga John Muke Adeline Morez Matthew Leavesley Mayukh Mondal François-Xavier Ricaut |
| author_facet | Mathilde André Nicolas Brucato Sébastien Plutniak Jason Kariwiga John Muke Adeline Morez Matthew Leavesley Mayukh Mondal François-Xavier Ricaut |
| author_sort | Mathilde André |
| collection | DOAJ |
| description | <h4>Objectives</h4>Altitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock et al., 1972; Cotes et al., 1974; Senn et al., 2010]. We tested the hypothesis that highlanders phenotypically differ from lowlanders in Papua New Guinea, as a result of inhabiting the highest mountains in Oceania for at least 20,000 years.<h4>Materials and methods</h4>We collected data for 13 different phenotypes related to altitude for 162 Papua New Guineans living at high altitude (Mont Wilhelm, 2,300-2,700 m above sea level (a.s.l.) and low altitude (Daru, <100m a.s.l.). Multilinear regressions were performed to detect differences between highlanders and lowlanders for phenotypic measurements related to body proportions, pulmonary function, and the circulatory system.<h4>Results</h4>Six phenotypes were significantly different between Papua New Guinean highlanders and lowlanders. Highlanders show shorter height (p-value = 0.001), smaller waist circumference (p-value = 0.002), larger Forced Vital Capacity (FVC) (p-value = 0.008), larger maximal (p-value = 3.20e -4) and minimal chest depth (p-value = 2.37e -5) and higher haemoglobin concentration (p-value = 3.36e -4).<h4>Discussion</h4>Our study reports specific phenotypes in Papua New Guinean highlanders potentially related to altitude adaptation. Similar to other human groups adapted to high altitude, the evolutionary history of Papua New Guineans appears to have also followed an adaptive biological strategy for altitude. |
| first_indexed | 2024-12-14T08:42:40Z |
| format | Article |
| id | doaj.art-5aebbc8524f14c0a908d0ab4e0f0a14f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:42:40Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5aebbc8524f14c0a908d0ab4e0f0a14f2022-12-21T23:09:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01167e025392110.1371/journal.pone.0253921Phenotypic differences between highlanders and lowlanders in Papua New Guinea.Mathilde AndréNicolas BrucatoSébastien PlutniakJason KariwigaJohn MukeAdeline MorezMatthew LeavesleyMayukh MondalFrançois-Xavier Ricaut<h4>Objectives</h4>Altitude is one of the most demanding environmental pressures for human populations. Highlanders from Asia, America and Africa have been shown to exhibit different biological adaptations, but Oceanian populations remain understudied [Woolcock et al., 1972; Cotes et al., 1974; Senn et al., 2010]. We tested the hypothesis that highlanders phenotypically differ from lowlanders in Papua New Guinea, as a result of inhabiting the highest mountains in Oceania for at least 20,000 years.<h4>Materials and methods</h4>We collected data for 13 different phenotypes related to altitude for 162 Papua New Guineans living at high altitude (Mont Wilhelm, 2,300-2,700 m above sea level (a.s.l.) and low altitude (Daru, <100m a.s.l.). Multilinear regressions were performed to detect differences between highlanders and lowlanders for phenotypic measurements related to body proportions, pulmonary function, and the circulatory system.<h4>Results</h4>Six phenotypes were significantly different between Papua New Guinean highlanders and lowlanders. Highlanders show shorter height (p-value = 0.001), smaller waist circumference (p-value = 0.002), larger Forced Vital Capacity (FVC) (p-value = 0.008), larger maximal (p-value = 3.20e -4) and minimal chest depth (p-value = 2.37e -5) and higher haemoglobin concentration (p-value = 3.36e -4).<h4>Discussion</h4>Our study reports specific phenotypes in Papua New Guinean highlanders potentially related to altitude adaptation. Similar to other human groups adapted to high altitude, the evolutionary history of Papua New Guineans appears to have also followed an adaptive biological strategy for altitude.https://doi.org/10.1371/journal.pone.0253921 |
| spellingShingle | Mathilde André Nicolas Brucato Sébastien Plutniak Jason Kariwiga John Muke Adeline Morez Matthew Leavesley Mayukh Mondal François-Xavier Ricaut Phenotypic differences between highlanders and lowlanders in Papua New Guinea. PLoS ONE |
| title | Phenotypic differences between highlanders and lowlanders in Papua New Guinea. |
| title_full | Phenotypic differences between highlanders and lowlanders in Papua New Guinea. |
| title_fullStr | Phenotypic differences between highlanders and lowlanders in Papua New Guinea. |
| title_full_unstemmed | Phenotypic differences between highlanders and lowlanders in Papua New Guinea. |
| title_short | Phenotypic differences between highlanders and lowlanders in Papua New Guinea. |
| title_sort | phenotypic differences between highlanders and lowlanders in papua new guinea |
| url | https://doi.org/10.1371/journal.pone.0253921 |
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