Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source
Abstract Direct utilization of CO2 into organic synthesis finds enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we describe...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-43289-w |
| _version_ | 1797452100419977216 |
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| author | Yuman Qin Robin Cauwenbergh Suman Pradhan Rakesh Maiti Philippe Franck Shoubhik Das |
| author_facet | Yuman Qin Robin Cauwenbergh Suman Pradhan Rakesh Maiti Philippe Franck Shoubhik Das |
| author_sort | Yuman Qin |
| collection | DOAJ |
| description | Abstract Direct utilization of CO2 into organic synthesis finds enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we describe a straightforward synthetic route for the synthesis of γ-lactams, a pivotal core structure of bioactive molecules, by using commercially available starting materials (alkenes and amines) and impure CO2 stream (exhaust gas is collected from the car) as the carbon source. This blueprint features a broad scope, excellent functional group compatibility and application to the late-stage transformation of existing pharmaceuticals and natural products to synthesize functionalized γ-lactams. We believe that our strategy will provide direct access to γ-lactams in a very sustainable way and will also enhance the Carbon Capture and Utilization (CCU) strategy. |
| first_indexed | 2024-03-09T15:03:53Z |
| format | Article |
| id | doaj.art-5aec79112112483996180b2078bd79b2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-09T15:03:53Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5aec79112112483996180b2078bd79b22023-11-26T13:45:14ZengNature PortfolioNature Communications2041-17232023-11-011411910.1038/s41467-023-43289-wStraightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon sourceYuman Qin0Robin Cauwenbergh1Suman Pradhan2Rakesh Maiti3Philippe Franck4Shoubhik Das5Department of Chemistry, University of BayreuthDepartment of Chemistry, Universiteit AntwerpenDepartment of Chemistry, University of BayreuthDepartment of Chemistry, University of BayreuthDepartment of Chemistry, Universiteit AntwerpenDepartment of Chemistry, University of BayreuthAbstract Direct utilization of CO2 into organic synthesis finds enormous applications to synthesize pharmaceuticals and fine chemicals. However, pure CO2 gas is essential to achieve these transformations, and the purification of CO2 is highly cost and energy intensive. Considering this, we describe a straightforward synthetic route for the synthesis of γ-lactams, a pivotal core structure of bioactive molecules, by using commercially available starting materials (alkenes and amines) and impure CO2 stream (exhaust gas is collected from the car) as the carbon source. This blueprint features a broad scope, excellent functional group compatibility and application to the late-stage transformation of existing pharmaceuticals and natural products to synthesize functionalized γ-lactams. We believe that our strategy will provide direct access to γ-lactams in a very sustainable way and will also enhance the Carbon Capture and Utilization (CCU) strategy.https://doi.org/10.1038/s41467-023-43289-w |
| spellingShingle | Yuman Qin Robin Cauwenbergh Suman Pradhan Rakesh Maiti Philippe Franck Shoubhik Das Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source Nature Communications |
| title | Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source |
| title_full | Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source |
| title_fullStr | Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source |
| title_full_unstemmed | Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source |
| title_short | Straightforward synthesis of functionalized γ-Lactams using impure CO2 stream as the carbon source |
| title_sort | straightforward synthesis of functionalized γ lactams using impure co2 stream as the carbon source |
| url | https://doi.org/10.1038/s41467-023-43289-w |
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