Negative Smad expression and regulation in the developing chick limb.
The inhibitory or negative Smads, Smad6 and Smad7, block TGFbeta superfamily signals of both the BMP and TGFbeta classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regul...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2663054?pdf=render |
| _version_ | 1811263030275604480 |
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| author | Neil Vargesson Ed Laufer |
| author_facet | Neil Vargesson Ed Laufer |
| author_sort | Neil Vargesson |
| collection | DOAJ |
| description | The inhibitory or negative Smads, Smad6 and Smad7, block TGFbeta superfamily signals of both the BMP and TGFbeta classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in limb mesenchyme indicates that negative Smad gene expression is regulated, at least in part, by BMP family signals. |
| first_indexed | 2024-04-12T19:37:36Z |
| format | Article |
| id | doaj.art-5aed6e324a124666a38a9055bb05ceb1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T19:37:36Z |
| publishDate | 2009-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5aed6e324a124666a38a9055bb05ceb12022-12-22T03:19:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0144e517310.1371/journal.pone.0005173Negative Smad expression and regulation in the developing chick limb.Neil VargessonEd LauferThe inhibitory or negative Smads, Smad6 and Smad7, block TGFbeta superfamily signals of both the BMP and TGFbeta classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in limb mesenchyme indicates that negative Smad gene expression is regulated, at least in part, by BMP family signals.http://europepmc.org/articles/PMC2663054?pdf=render |
| spellingShingle | Neil Vargesson Ed Laufer Negative Smad expression and regulation in the developing chick limb. PLoS ONE |
| title | Negative Smad expression and regulation in the developing chick limb. |
| title_full | Negative Smad expression and regulation in the developing chick limb. |
| title_fullStr | Negative Smad expression and regulation in the developing chick limb. |
| title_full_unstemmed | Negative Smad expression and regulation in the developing chick limb. |
| title_short | Negative Smad expression and regulation in the developing chick limb. |
| title_sort | negative smad expression and regulation in the developing chick limb |
| url | http://europepmc.org/articles/PMC2663054?pdf=render |
| work_keys_str_mv | AT neilvargesson negativesmadexpressionandregulationinthedevelopingchicklimb AT edlaufer negativesmadexpressionandregulationinthedevelopingchicklimb |