Fundamentals of bladder tissue engineering
A wide range of injuries could affect the bladder and lead to eventual loss of its integrity, with the need for replacement or repair. Augmentation ileocystoplasty is considered till now the gold standard option for bladder replacement, despite its associated complications. Bladder tissue engineerin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2013-06-01
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| Series: | African Journal of Urology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110570413000301 |
| _version_ | 1829514721820147712 |
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| author | W. Mahfouz S. Elsalmy J. Corcos A.S. Fayed |
| author_facet | W. Mahfouz S. Elsalmy J. Corcos A.S. Fayed |
| author_sort | W. Mahfouz |
| collection | DOAJ |
| description | A wide range of injuries could affect the bladder and lead to eventual loss of its integrity, with the need for replacement or repair. Augmentation ileocystoplasty is considered till now the gold standard option for bladder replacement, despite its associated complications. Bladder tissue engineering appears as an appealing alternative through development of biological substitutes, which could restore structural and functional aspects of damaged tissues and organs.
Tissue engineering relies upon three essential pillars; the scaffold, the cells seeded on scaffolds and lastly the environmental conditions, including growth factors, cytokines and extracellular matrix (ECM) which promote angiogenesis and neurogenesis of the regenerated organs. The choice of the scaffold and the type of cells is a crucial and fundamental step in regenerative medicine. In this review article, we demonstrated these three crucial factors of bladder tissue engineering, with the pros and cons of each scaffold type and cell type used. |
| first_indexed | 2024-12-16T13:22:29Z |
| format | Article |
| id | doaj.art-5aed9f0dc3ac4c7d8ca837aa3842eafe |
| institution | Directory Open Access Journal |
| issn | 1110-5704 |
| language | English |
| last_indexed | 2024-12-16T13:22:29Z |
| publishDate | 2013-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | African Journal of Urology |
| spelling | doaj.art-5aed9f0dc3ac4c7d8ca837aa3842eafe2022-12-21T22:30:19ZengSpringerOpenAfrican Journal of Urology1110-57042013-06-01192515710.1016/j.afju.2013.01.006Fundamentals of bladder tissue engineeringW. Mahfouz0S. Elsalmy1J. Corcos2A.S. Fayed3Urology Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptUrology Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptUrology Department, Jewish General Hospital, McGill University, Montreal, CanadaUrology Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptA wide range of injuries could affect the bladder and lead to eventual loss of its integrity, with the need for replacement or repair. Augmentation ileocystoplasty is considered till now the gold standard option for bladder replacement, despite its associated complications. Bladder tissue engineering appears as an appealing alternative through development of biological substitutes, which could restore structural and functional aspects of damaged tissues and organs. Tissue engineering relies upon three essential pillars; the scaffold, the cells seeded on scaffolds and lastly the environmental conditions, including growth factors, cytokines and extracellular matrix (ECM) which promote angiogenesis and neurogenesis of the regenerated organs. The choice of the scaffold and the type of cells is a crucial and fundamental step in regenerative medicine. In this review article, we demonstrated these three crucial factors of bladder tissue engineering, with the pros and cons of each scaffold type and cell type used.http://www.sciencedirect.com/science/article/pii/S1110570413000301ScaffoldStem cellsBladder tissue engineeringDecellularizationBladder acellular matrix |
| spellingShingle | W. Mahfouz S. Elsalmy J. Corcos A.S. Fayed Fundamentals of bladder tissue engineering African Journal of Urology Scaffold Stem cells Bladder tissue engineering Decellularization Bladder acellular matrix |
| title | Fundamentals of bladder tissue engineering |
| title_full | Fundamentals of bladder tissue engineering |
| title_fullStr | Fundamentals of bladder tissue engineering |
| title_full_unstemmed | Fundamentals of bladder tissue engineering |
| title_short | Fundamentals of bladder tissue engineering |
| title_sort | fundamentals of bladder tissue engineering |
| topic | Scaffold Stem cells Bladder tissue engineering Decellularization Bladder acellular matrix |
| url | http://www.sciencedirect.com/science/article/pii/S1110570413000301 |
| work_keys_str_mv | AT wmahfouz fundamentalsofbladdertissueengineering AT selsalmy fundamentalsofbladdertissueengineering AT jcorcos fundamentalsofbladdertissueengineering AT asfayed fundamentalsofbladdertissueengineering |