The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma
BackgroundIsocitrate dehydrogenase-wildtype glioblastoma (IDH-wildtype GBM) and IDH-mutant astrocytoma have distinct biological behaviors and clinical outcomes. The location of brain tumors is closely associated not only with clinical symptoms and prognosis but also with key molecular alterations su...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1264322/full |
| _version_ | 1827596461058031616 |
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| author | Hongbo Bao Hongbo Bao Huan Wang Qian Sun Yujie Wang Hui Liu Peng Liang Zhonghua Lv |
| author_facet | Hongbo Bao Hongbo Bao Huan Wang Qian Sun Yujie Wang Hui Liu Peng Liang Zhonghua Lv |
| author_sort | Hongbo Bao |
| collection | DOAJ |
| description | BackgroundIsocitrate dehydrogenase-wildtype glioblastoma (IDH-wildtype GBM) and IDH-mutant astrocytoma have distinct biological behaviors and clinical outcomes. The location of brain tumors is closely associated not only with clinical symptoms and prognosis but also with key molecular alterations such as IDH. Therefore, we hypothesize that the key brain regions influencing the prognosis of glioblastoma and astrocytoma are likely to differ. This study aims to (1) identify specific regions that are associated with the Karnofsky Performance Scale (KPS) or overall survival (OS) in IDH-wildtype GBM and IDH-mutant astrocytoma and (2) test whether the involvement of these regions could act as a prognostic indicator.MethodsA total of 111 patients with IDH-wildtype GBM and 78 patients with IDH-mutant astrocytoma from the Cancer Imaging Archive database were included in the study. Voxel-based lesion-symptom mapping (VLSM) was used to identify key brain areas for lower KPS and shorter OS. Next, we analyzed the structural and cognitive dysfunction associated with these regions. The survival analysis was carried out using Kaplan–Meier survival curves. Another 72 GBM patients and 48 astrocytoma patients from Harbin Medical University Cancer Hospital were used as a validation cohort.ResultsTumors located in the insular cortex, parahippocampal gyrus, and middle and superior temporal gyrus of the left hemisphere tended to lead to lower KPS and shorter OS in IDH-wildtype GBM. The regions that were significantly correlated with lower KPS in IDH-mutant astrocytoma included the subcallosal cortex and cingulate gyrus. These regions were associated with diverse structural and cognitive impairments. The involvement of these regions was an independent predictor for shorter survival in both GBM and astrocytoma.ConclusionThis study identified the specific regions that were significantly associated with OS or KPS in glioma. The results may help neurosurgeons evaluate patient survival before surgery and understand the pathogenic mechanisms of glioma in depth. |
| first_indexed | 2024-03-09T03:10:53Z |
| format | Article |
| id | doaj.art-5aee6d74db824908a040fc73547a5d97 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-09T03:10:53Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5aee6d74db824908a040fc73547a5d972023-12-04T05:02:39ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-12-011410.3389/fneur.2023.12643221264322The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in gliomaHongbo Bao0Hongbo Bao1Huan Wang2Qian Sun3Yujie Wang4Hui Liu5Peng Liang6Zhonghua Lv7Department of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, ChinaBackgroundIsocitrate dehydrogenase-wildtype glioblastoma (IDH-wildtype GBM) and IDH-mutant astrocytoma have distinct biological behaviors and clinical outcomes. The location of brain tumors is closely associated not only with clinical symptoms and prognosis but also with key molecular alterations such as IDH. Therefore, we hypothesize that the key brain regions influencing the prognosis of glioblastoma and astrocytoma are likely to differ. This study aims to (1) identify specific regions that are associated with the Karnofsky Performance Scale (KPS) or overall survival (OS) in IDH-wildtype GBM and IDH-mutant astrocytoma and (2) test whether the involvement of these regions could act as a prognostic indicator.MethodsA total of 111 patients with IDH-wildtype GBM and 78 patients with IDH-mutant astrocytoma from the Cancer Imaging Archive database were included in the study. Voxel-based lesion-symptom mapping (VLSM) was used to identify key brain areas for lower KPS and shorter OS. Next, we analyzed the structural and cognitive dysfunction associated with these regions. The survival analysis was carried out using Kaplan–Meier survival curves. Another 72 GBM patients and 48 astrocytoma patients from Harbin Medical University Cancer Hospital were used as a validation cohort.ResultsTumors located in the insular cortex, parahippocampal gyrus, and middle and superior temporal gyrus of the left hemisphere tended to lead to lower KPS and shorter OS in IDH-wildtype GBM. The regions that were significantly correlated with lower KPS in IDH-mutant astrocytoma included the subcallosal cortex and cingulate gyrus. These regions were associated with diverse structural and cognitive impairments. The involvement of these regions was an independent predictor for shorter survival in both GBM and astrocytoma.ConclusionThis study identified the specific regions that were significantly associated with OS or KPS in glioma. The results may help neurosurgeons evaluate patient survival before surgery and understand the pathogenic mechanisms of glioma in depth.https://www.frontiersin.org/articles/10.3389/fneur.2023.1264322/fullGBMastrocytomaIDHVLSMsurvival timeKPS |
| spellingShingle | Hongbo Bao Hongbo Bao Huan Wang Qian Sun Yujie Wang Hui Liu Peng Liang Zhonghua Lv The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma Frontiers in Neurology GBM astrocytoma IDH VLSM survival time KPS |
| title | The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma |
| title_full | The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma |
| title_fullStr | The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma |
| title_full_unstemmed | The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma |
| title_short | The involvement of brain regions associated with lower KPS and shorter survival time predicts a poor prognosis in glioma |
| title_sort | involvement of brain regions associated with lower kps and shorter survival time predicts a poor prognosis in glioma |
| topic | GBM astrocytoma IDH VLSM survival time KPS |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1264322/full |
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