Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach
Chromium (III) oxide nanoparticles (NPs) have a wide range of industrial applications, particularly in the production of lithium-ion batteries; however, the toxicity of these NPs has not been studied extensively. The phytotoxicity and genotoxicity of chromium (III) oxide NPs have not been assessed,...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-06-01
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| Series: | Emerging Contaminants |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665023000914 |
| _version_ | 1827237617511432192 |
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| author | Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun Kim |
| author_facet | Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun Kim |
| author_sort | Uhram Song |
| collection | DOAJ |
| description | Chromium (III) oxide nanoparticles (NPs) have a wide range of industrial applications, particularly in the production of lithium-ion batteries; however, the toxicity of these NPs has not been studied extensively. The phytotoxicity and genotoxicity of chromium (III) oxide NPs have not been assessed, and only one study reported their cytotoxicity, underscoring the need to perform comprehensive toxicity studies on these NPs. Here, we showed that chromium (III) oxide NPs had no effect on germination rates, and only decreased root elongation in L. sativa as determined by root elongation and biomass studies. Chromium (III) oxide NPs had no phytotoxic effects under environmental realistic conditions, whereas they had cytotoxic effects against HK-2 and Raw 264.7 cells in vitro. However, the cytotoxicity of chromium (III) oxide NPs did not occur under environmentally realistic conditions. The genotoxicity of chromium (III) oxide NPs was not significant in HK-2 cells, suggesting that the potential environmental cytotoxicity of chromium (III) oxide NPs is limited. This study proposes comprehensive phytotoxicity, cytotoxicity, and genotoxicity testing tools that would be easy, safe, and effective for evaluating the toxicity of NPs. This integrated testing system could be an accurate and stable method for evaluating the toxicity of other nanomaterials. |
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| format | Article |
| id | doaj.art-5aef0cc6e5cd4567a76eacaf9d84d980 |
| institution | Directory Open Access Journal |
| issn | 2405-6650 |
| language | English |
| last_indexed | 2025-03-21T20:39:45Z |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Emerging Contaminants |
| spelling | doaj.art-5aef0cc6e5cd4567a76eacaf9d84d9802024-06-01T04:22:28ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502024-06-01102100293Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approachUhram Song0Kwon Soon Pyo1Ho Hyun Song2Sun ryung Lee3Jieun Kim4Department of Biology, Jeju National University, Jeju, 63243, South KoreaDepartment of Biology, Jeju National University, Jeju, 63243, South KoreaDepartment of Interdisciplinary Program in Biomedical Science, Graduate School, Soonchunhyang University, Asan, Chungcheongnam-do, South KoreaDepartment of Biology, Jeju National University, Jeju, 63243, South Korea; Corresponding author.Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, 04401, South Korea; Corresponding author.Chromium (III) oxide nanoparticles (NPs) have a wide range of industrial applications, particularly in the production of lithium-ion batteries; however, the toxicity of these NPs has not been studied extensively. The phytotoxicity and genotoxicity of chromium (III) oxide NPs have not been assessed, and only one study reported their cytotoxicity, underscoring the need to perform comprehensive toxicity studies on these NPs. Here, we showed that chromium (III) oxide NPs had no effect on germination rates, and only decreased root elongation in L. sativa as determined by root elongation and biomass studies. Chromium (III) oxide NPs had no phytotoxic effects under environmental realistic conditions, whereas they had cytotoxic effects against HK-2 and Raw 264.7 cells in vitro. However, the cytotoxicity of chromium (III) oxide NPs did not occur under environmentally realistic conditions. The genotoxicity of chromium (III) oxide NPs was not significant in HK-2 cells, suggesting that the potential environmental cytotoxicity of chromium (III) oxide NPs is limited. This study proposes comprehensive phytotoxicity, cytotoxicity, and genotoxicity testing tools that would be easy, safe, and effective for evaluating the toxicity of NPs. This integrated testing system could be an accurate and stable method for evaluating the toxicity of other nanomaterials.http://www.sciencedirect.com/science/article/pii/S2405665023000914NanoparticlePlant growthCell viabilityChromium (III) oxideNephrotoxicity |
| spellingShingle | Uhram Song Kwon Soon Pyo Ho Hyun Song Sun ryung Lee Jieun Kim Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach Emerging Contaminants Nanoparticle Plant growth Cell viability Chromium (III) oxide Nephrotoxicity |
| title | Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach |
| title_full | Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach |
| title_fullStr | Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach |
| title_full_unstemmed | Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach |
| title_short | Environmental toxicity assessment of chromium (III) oxide nanoparticles using a phytotoxic, cytotoxic, and genotoxic approach |
| title_sort | environmental toxicity assessment of chromium iii oxide nanoparticles using a phytotoxic cytotoxic and genotoxic approach |
| topic | Nanoparticle Plant growth Cell viability Chromium (III) oxide Nephrotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2405665023000914 |
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