Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Abstract Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium and phosphorus content. However, the r...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-11-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-023-00290-9 |
| _version_ | 1797630373685886976 |
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| author | Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu |
| author_facet | Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu |
| author_sort | Guanyue Su |
| collection | DOAJ |
| description | Abstract Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium and phosphorus content. However, the role of MVs in the progression of osteoporosis is poorly understood. Here, we report that annexin A5, an important component of the matrix vesicle membrane, plays a vital role in bone matrix homeostasis in the deterioration of osteoporosis. We first identified annexin A5 from adherent MVs but not dissociative MVs of osteoblasts and found that it could be sharply decreased in the bone matrix during the occurrence of osteoporosis based on ovariectomized mice. We then confirmed its potential in mediating the mineralization of the precursor osteoblast lineage via its initial binding with collagen type I to achieve MV adhesion and the subsequent activation of cellular autophagy. Finally, we proved its protective role in resisting bone loss by applying it to osteoporotic mice. Taken together, these data revealed the importance of annexin A5, originating from adherent MVs of osteoblasts, in bone matrix remodeling of osteoporosis and provided a new strategy for the treatment and intervention of bone loss. |
| first_indexed | 2024-03-11T11:06:29Z |
| format | Article |
| id | doaj.art-5af0d59e7bea40b8bcc8ad0a20c670e9 |
| institution | Directory Open Access Journal |
| issn | 2095-6231 |
| language | English |
| last_indexed | 2024-03-11T11:06:29Z |
| publishDate | 2023-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj.art-5af0d59e7bea40b8bcc8ad0a20c670e92023-11-12T12:09:49ZengNature Publishing GroupBone Research2095-62312023-11-0111111610.1038/s41413-023-00290-9Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralizationGuanyue Su0Demao Zhang1Tiantian Li2Tong Pei3Jie Yang4Shasha Tu5Sijun Liu6Jie Ren7Yaojia Zhang8Mengmeng Duan9Xinrui Yang10Yang Shen11Chenchen Zhou12Jing Xie13Xiaoheng Liu14Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan UniversityInstitute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan UniversityAbstract Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium and phosphorus content. However, the role of MVs in the progression of osteoporosis is poorly understood. Here, we report that annexin A5, an important component of the matrix vesicle membrane, plays a vital role in bone matrix homeostasis in the deterioration of osteoporosis. We first identified annexin A5 from adherent MVs but not dissociative MVs of osteoblasts and found that it could be sharply decreased in the bone matrix during the occurrence of osteoporosis based on ovariectomized mice. We then confirmed its potential in mediating the mineralization of the precursor osteoblast lineage via its initial binding with collagen type I to achieve MV adhesion and the subsequent activation of cellular autophagy. Finally, we proved its protective role in resisting bone loss by applying it to osteoporotic mice. Taken together, these data revealed the importance of annexin A5, originating from adherent MVs of osteoblasts, in bone matrix remodeling of osteoporosis and provided a new strategy for the treatment and intervention of bone loss.https://doi.org/10.1038/s41413-023-00290-9 |
| spellingShingle | Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization Bone Research |
| title | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization |
| title_full | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization |
| title_fullStr | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization |
| title_full_unstemmed | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization |
| title_short | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization |
| title_sort | annexin a5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization |
| url | https://doi.org/10.1038/s41413-023-00290-9 |
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