Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome
Background: Vitamin D deficiency (VDD) is highly prevalent in critically ill children. Although its role in immunity is hypothesized, its role in mortality is not clear. Objectives: To study the prevalence of VDD in critically ill children and its effect on outcome. Material and Methods: This prospe...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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Series: | Journal of Pediatric Critical Care |
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Online Access: | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2018;volume=5;issue=3;spage=22;epage=28;aulast=Jyoti |
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author | R Satapathy Jyoti K Meher Bijay D Pradhan Deepti Mahar Jatadhari K Maji Benoj K Routray Rakesh |
author_facet | R Satapathy Jyoti K Meher Bijay D Pradhan Deepti Mahar Jatadhari K Maji Benoj K Routray Rakesh |
author_sort | R Satapathy Jyoti |
collection | DOAJ |
description | Background: Vitamin D deficiency (VDD) is highly prevalent in critically ill children. Although its role in immunity is hypothesized, its role in mortality is not clear. Objectives: To study the prevalence of VDD in critically ill children and its effect on outcome. Material and Methods: This prospective observational study was done at a tertiary care PICU from Nov 2016 to Dec 2017. Critically ill children (aged 1 month to 14 years) were enrolled for study. 25(OH) Vitamin D estimation was done within 24 hour of admission. Outcome measures recorded were PRISM III score, need of mechanical ventilation, ICU stay duration and death. Descriptive analysis, independent sample ‘t’ test, Mann-Whitney U test done with SPSS 24 and ROC analysis done. Results: Out of 78 children, 52 (66.7%) were VDD. There was no significant difference in PRISM III score, predicted mortality at admission and need of mechanical ventilation between children with and without VDD. VDD group had younger age at admission (54.85±53.12 vs. 78.54±64.55mo, p 0.048) and longer PICU stays (10.15±12.30 vs. 4.23±2.69 days, p 0.018). Mortality was insignificantly higher in VDD group (p=0.477). In prediction of mortality, vitamin D is a poor predictor of outcome (AUC 0.557, p 0.479) with low sensitivity (45.45%) and specificity (85.71%) as compared to PRISM III score (AUC 0.747, p= 0.0001). Conclusions: High prevalence of VDD is seen in critically ill children. Children with VDD have younger age at admission, longer ICU stay without significantly higher mortality. VDD is a poor predictor of mortality in critically ill children. |
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institution | Directory Open Access Journal |
issn | 2349-6592 2455-7099 |
language | English |
last_indexed | 2024-12-23T23:57:03Z |
publishDate | 2018-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Journal of Pediatric Critical Care |
spelling | doaj.art-5af15f8daa0c4ce3a57517dbb27c84c92022-12-21T17:25:13ZengWolters Kluwer Medknow PublicationsJournal of Pediatric Critical Care2349-65922455-70992018-01-0153222810.21304/2018.0503.00384Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcomeR Satapathy JyotiK Meher BijayD Pradhan DeeptiMahar JatadhariK Maji BenojK Routray RakeshBackground: Vitamin D deficiency (VDD) is highly prevalent in critically ill children. Although its role in immunity is hypothesized, its role in mortality is not clear. Objectives: To study the prevalence of VDD in critically ill children and its effect on outcome. Material and Methods: This prospective observational study was done at a tertiary care PICU from Nov 2016 to Dec 2017. Critically ill children (aged 1 month to 14 years) were enrolled for study. 25(OH) Vitamin D estimation was done within 24 hour of admission. Outcome measures recorded were PRISM III score, need of mechanical ventilation, ICU stay duration and death. Descriptive analysis, independent sample ‘t’ test, Mann-Whitney U test done with SPSS 24 and ROC analysis done. Results: Out of 78 children, 52 (66.7%) were VDD. There was no significant difference in PRISM III score, predicted mortality at admission and need of mechanical ventilation between children with and without VDD. VDD group had younger age at admission (54.85±53.12 vs. 78.54±64.55mo, p 0.048) and longer PICU stays (10.15±12.30 vs. 4.23±2.69 days, p 0.018). Mortality was insignificantly higher in VDD group (p=0.477). In prediction of mortality, vitamin D is a poor predictor of outcome (AUC 0.557, p 0.479) with low sensitivity (45.45%) and specificity (85.71%) as compared to PRISM III score (AUC 0.747, p= 0.0001). Conclusions: High prevalence of VDD is seen in critically ill children. Children with VDD have younger age at admission, longer ICU stay without significantly higher mortality. VDD is a poor predictor of mortality in critically ill children.http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2018;volume=5;issue=3;spage=22;epage=28;aulast=Jyotivitamin dcritically in children picuprism iii score |
spellingShingle | R Satapathy Jyoti K Meher Bijay D Pradhan Deepti Mahar Jatadhari K Maji Benoj K Routray Rakesh Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome Journal of Pediatric Critical Care vitamin d critically in children picu prism iii score |
title | Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome |
title_full | Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome |
title_fullStr | Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome |
title_full_unstemmed | Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome |
title_short | Vitamin D status in critically ill children admitted to pediatric intensive care unit with relation to outcome |
title_sort | vitamin d status in critically ill children admitted to pediatric intensive care unit with relation to outcome |
topic | vitamin d critically in children picu prism iii score |
url | http://www.jpcc.org.in/article.asp?issn=2349-6592;year=2018;volume=5;issue=3;spage=22;epage=28;aulast=Jyoti |
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