Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits

Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits

gamma-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein, catalyzing the formation of amyloid beta peptides that form amyloid plaques, which contribute to Alzheimer’s disease pathogenesis. gamma-Secretase also cleaves Notch, among many other type I trans...

Full description

Bibliographic Details
Main Authors:	Natalya eGertsik, Danica eChiu, Yueming eLI
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-01-01
Series:	Frontiers in Aging Neuroscience
Subjects:	gamma-secretase Alzheimer’s disease APP HIF-1alpha Notch Presenilin
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00342/full

Similar Items

Conserved “PAL” sequence in presenilins is essential for γ-secretase activity, but not required for formation or stabilization of γ-secretase complexes
by: Jun Wang, et al.
Published: (2004-04-01)

The Potential of Gamma Secretase as a Therapeutic Target for Cardiac Diseases
by: Sujoita Sen, et al.
Published: (2021-12-01)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
by: Christian B. Lessard, et al.
Published: (2020-05-01)

Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer’s Disease
by: Meewhi Kim, et al.
Published: (2023-01-01)

Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease
by: Gunnar Nordvall, et al.
Published: (2023-10-01)

Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations
by: Meewhi Kim, et al.
Published: (2021-12-01)

Jagged1 protein processing in the developing mammalian lens
by: Mina Azimi, et al.
Published: (2019-03-01)

How γ-secretase hits a moving target
by: Charles R Sanders
Published: (2016-08-01)

Inhibition of Gamma-Secretase Promotes Axon Regeneration After a Complete Spinal Cord Injury
by: Daniel Sobrido-Cameán, et al.
Published: (2020-03-01)

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates
by: Stephanie Baulac, et al.
Published: (2003-11-01)

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface
by: Abril Angélica Escamilla-Ayala, et al.
Published: (2020-07-01)

Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome
by: Fiorenza Stagni, et al.
Published: (2017-07-01)

Sampling the conformational space of the catalytic subunit of human γ-secretase
by: Xiao-chen Bai, et al.
Published: (2015-12-01)

Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors
by: Svetlana Sharifulina, et al.
Published: (2022-10-01)

Presenilins and γ-Secretase in Membrane Proteostasis
by: Naoto Oikawa, et al.
Published: (2019-03-01)

Rutin Potentially Binds the Gamma Secretase Catalytic Site, Down Regulates the Notch Signaling Pathway and Reduces Sphere Formation in Colonospheres
by: Atul Kumar Singh, et al.
Published: (2022-09-01)

γ‐Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct
by: Yong Ran, et al.
Published: (2017-07-01)

Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification
by: Zheng Wang, et al.
Published: (2023-09-01)

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
by: Frank Raven, et al.
Published: (2017-10-01)

Limited Substrate Specificity of PS/γ-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells
by: Mei C. Q. Houser, et al.
Published: (2021-05-01)

Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma
by: Yasmin Abedin, et al.
Published: (2022-05-01)

Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment
by: Yiping Yang, et al.
Published: (2021-09-01)

Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes
by: Keiro Shirotani, et al.
Published: (2007-07-01)

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome
by: Andrea Giacomini, et al.
Published: (2015-10-01)

Interpreting the spectrum of gamma-secretase complex missense variation in the context of hidradenitis suppurativa—An in-silico study
by: Dillon Mintoff, et al.
Published: (2022-09-01)

Secretases Related to Amyloid Precursor Protein Processing
by: Xiaoling Liu, et al.
Published: (2021-12-01)

Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy
by: Maryam Ghanbari-Movahed, et al.
Published: (2021-02-01)

Regulated intramembrane proteolysis, innate immunity and therapeutic targets in Alzheimer’s disease
by: Caroline Coleman-Vaughan, et al.
Published: (2016-04-01)

A Novel NIR-FRET Biosensor for Reporting PS/γ-Secretase Activity in Live Cells
by: Mei CQ Houser, et al.
Published: (2020-10-01)

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients
by: Felix Dinkel, et al.
Published: (2020-07-01)

Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism <it>Dictyostelium discoideum</it>
by: Myre Michael A
Published: (2012-04-01)

Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice
by: Woo Bin Yun, et al.
Published: (2016-12-01)

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains
by: Shekhar Kedia, et al.
Published: (2021-10-01)

Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression
by: Shinsuke Suzuki, et al.
Published: (2022-10-01)

Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors
by: Silvia T. Erni, et al.
Published: (2021-08-01)

Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1)
by: Sébastien S Hébert, et al.
Published: (2003-08-01)

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma
by: Prasoon Agarwal, et al.
Published: (2023-05-01)

A γ-Secretase Inhibitor Attenuates Cell Cycle Progression and Invasion in Human Oral Squamous Cell Carcinoma: An In Vitro Study
by: Sarai Pongjantarasatian, et al.
Published: (2022-08-01)

Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation
by: David P. Sparling, et al.
Published: (2020-01-01)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
by: David M Bolduc, et al.
Published: (2016-08-01)