Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism
The aim of this study was to assess Corvis ST biomechanical indices in reference to corneal enantiomorphism. In a prospective observational cohort study, 117 eyes from 63 patients with normal or keratoconus corneas were assessed by three independent observers. In the control group (n = 62), no signi...
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/690 |
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| author | Vincent Borderie Juliette Beauruel Roxane Cuyaubère Cristina Georgeon Benjamin Memmi Otman Sandali |
| author_facet | Vincent Borderie Juliette Beauruel Roxane Cuyaubère Cristina Georgeon Benjamin Memmi Otman Sandali |
| author_sort | Vincent Borderie |
| collection | DOAJ |
| description | The aim of this study was to assess Corvis ST biomechanical indices in reference to corneal enantiomorphism. In a prospective observational cohort study, 117 eyes from 63 patients with normal or keratoconus corneas were assessed by three independent observers. In the control group (n = 62), no significant differences were observed between the three observers for all indices. The best reproducibility was obtained with pachymetry and the weakest with CBI. All indices but CBI and arc length featured COV < 10%. All indices except the PD and SSI correlated with pachymetry; all but Rad correlated with IOP. The comparison of the thinnest with the thickest corneas showed no significant differences for any index except pachymetry. In the keratoconus group (n = 55), loss of corneal enantiomorphism was confirmed for all indices except the arc length, velocity, and PD. Significant differences between both groups were found for all indices, even after adjustment for pachymetry and intraocular pressure. The CBI featured the best accuracy (92%), sensitivity (91%), and graphical relevance for keratoconus diagnosis. However, its reproducibility was weak in normal corneas and was strongly dependent on corneal thickness. The SSI was independent of corneal thickness, highly reproducible, and provided the expected enantiomorphism characteristics in both groups, making it a relevant biomarker of biomechanical corneal behavior. |
| first_indexed | 2024-03-09T12:09:34Z |
| format | Article |
| id | doaj.art-5af5432fe02b441a8dbc11a8c769558f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:09:34Z |
| publishDate | 2023-01-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-5af5432fe02b441a8dbc11a8c769558f2023-11-30T22:53:31ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112269010.3390/jcm12020690Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal EnantiomorphismVincent Borderie0Juliette Beauruel1Roxane Cuyaubère2Cristina Georgeon3Benjamin Memmi4Otman Sandali5GRC 32, Transplantation et Thérapies Innovantes de la Cornée, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Sorbonne Université, 75006 Paris, FranceGRC 32, Transplantation et Thérapies Innovantes de la Cornée, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Sorbonne Université, 75006 Paris, FranceGRC 32, Transplantation et Thérapies Innovantes de la Cornée, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Sorbonne Université, 75006 Paris, FranceGRC 32, Transplantation et Thérapies Innovantes de la Cornée, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Sorbonne Université, 75006 Paris, FranceGRC 32, Transplantation et Thérapies Innovantes de la Cornée, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Sorbonne Université, 75006 Paris, FranceGRC 32, Transplantation et Thérapies Innovantes de la Cornée, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Sorbonne Université, 75006 Paris, FranceThe aim of this study was to assess Corvis ST biomechanical indices in reference to corneal enantiomorphism. In a prospective observational cohort study, 117 eyes from 63 patients with normal or keratoconus corneas were assessed by three independent observers. In the control group (n = 62), no significant differences were observed between the three observers for all indices. The best reproducibility was obtained with pachymetry and the weakest with CBI. All indices but CBI and arc length featured COV < 10%. All indices except the PD and SSI correlated with pachymetry; all but Rad correlated with IOP. The comparison of the thinnest with the thickest corneas showed no significant differences for any index except pachymetry. In the keratoconus group (n = 55), loss of corneal enantiomorphism was confirmed for all indices except the arc length, velocity, and PD. Significant differences between both groups were found for all indices, even after adjustment for pachymetry and intraocular pressure. The CBI featured the best accuracy (92%), sensitivity (91%), and graphical relevance for keratoconus diagnosis. However, its reproducibility was weak in normal corneas and was strongly dependent on corneal thickness. The SSI was independent of corneal thickness, highly reproducible, and provided the expected enantiomorphism characteristics in both groups, making it a relevant biomarker of biomechanical corneal behavior.https://www.mdpi.com/2077-0383/12/2/690biomechanicscorneaenantiomorphismkeratoconus |
| spellingShingle | Vincent Borderie Juliette Beauruel Roxane Cuyaubère Cristina Georgeon Benjamin Memmi Otman Sandali Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism Journal of Clinical Medicine biomechanics cornea enantiomorphism keratoconus |
| title | Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism |
| title_full | Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism |
| title_fullStr | Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism |
| title_full_unstemmed | Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism |
| title_short | Comprehensive Assessment of Corvis ST Biomechanical Indices in Normal and Keratoconus Corneas with Reference to Corneal Enantiomorphism |
| title_sort | comprehensive assessment of corvis st biomechanical indices in normal and keratoconus corneas with reference to corneal enantiomorphism |
| topic | biomechanics cornea enantiomorphism keratoconus |
| url | https://www.mdpi.com/2077-0383/12/2/690 |
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