Cortical connectomic mediations on gamma band synchronization in schizophrenia
Abstract Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disor...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-01-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-022-02300-6 |
| _version_ | 1797945671481819136 |
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| author | Xiaoming Du Stephanie Hare Ann Summerfelt Bhim M. Adhikari Laura Garcia Wyatt Marshall Peng Zan Mark Kvarta Eric Goldwaser Heather Bruce Si Gao Hemalatha Sampath Peter Kochunov Jonathan Z. Simon L. Elliot Hong |
| author_facet | Xiaoming Du Stephanie Hare Ann Summerfelt Bhim M. Adhikari Laura Garcia Wyatt Marshall Peng Zan Mark Kvarta Eric Goldwaser Heather Bruce Si Gao Hemalatha Sampath Peter Kochunov Jonathan Z. Simon L. Elliot Hong |
| author_sort | Xiaoming Du |
| collection | DOAJ |
| description | Abstract Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in patients and controls separately and in the combined sample. The mediation analysis further confirmed that the deficit of gamma band ASSR in schizophrenia was nearly fully mediated by three of the rsFC circuits between right superior temporal gyrus—left medial prefrontal cortex (MPFC), left MPFC—left postcentral gyrus (PoG), and left precentral gyrus—right PoG. Gamma-band ASSR deficits in schizophrenia may be associated with deficient circuitry level connectivity to support gamma frequency synchronization. Correcting gamma band deficits in schizophrenia may require corrective interventions to normalize these aberrant networks. |
| first_indexed | 2024-04-10T20:59:51Z |
| format | Article |
| id | doaj.art-5af5ae085cfe4fa19d64a2635f262793 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-10T20:59:51Z |
| publishDate | 2023-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-5af5ae085cfe4fa19d64a2635f2627932023-01-22T12:25:56ZengNature Publishing GroupTranslational Psychiatry2158-31882023-01-0113111010.1038/s41398-022-02300-6Cortical connectomic mediations on gamma band synchronization in schizophreniaXiaoming Du0Stephanie Hare1Ann Summerfelt2Bhim M. Adhikari3Laura Garcia4Wyatt Marshall5Peng Zan6Mark Kvarta7Eric Goldwaser8Heather Bruce9Si Gao10Hemalatha Sampath11Peter Kochunov12Jonathan Z. Simon13L. Elliot Hong14Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineDepartment of Electrical & Computer Engineering, University of MarylandMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineDepartment of Electrical & Computer Engineering, University of MarylandMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of MedicineAbstract Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophrenia remain poorly understood. Sixty-six patients with schizophrenia spectrum disorders and 85 age- and gender-matched healthy controls completed one electroencephalography session measuring 40 Hz ASSR and one imaging session for resting-state functional connectivity (rsFC) assessments. The associations between the normalized power of 40 Hz ASSR and rsFC were assessed via linear regression and mediation models. We found that rsFC among auditory, precentral, postcentral, and prefrontal cortices were positively associated with 40 Hz ASSR in patients and controls separately and in the combined sample. The mediation analysis further confirmed that the deficit of gamma band ASSR in schizophrenia was nearly fully mediated by three of the rsFC circuits between right superior temporal gyrus—left medial prefrontal cortex (MPFC), left MPFC—left postcentral gyrus (PoG), and left precentral gyrus—right PoG. Gamma-band ASSR deficits in schizophrenia may be associated with deficient circuitry level connectivity to support gamma frequency synchronization. Correcting gamma band deficits in schizophrenia may require corrective interventions to normalize these aberrant networks.https://doi.org/10.1038/s41398-022-02300-6 |
| spellingShingle | Xiaoming Du Stephanie Hare Ann Summerfelt Bhim M. Adhikari Laura Garcia Wyatt Marshall Peng Zan Mark Kvarta Eric Goldwaser Heather Bruce Si Gao Hemalatha Sampath Peter Kochunov Jonathan Z. Simon L. Elliot Hong Cortical connectomic mediations on gamma band synchronization in schizophrenia Translational Psychiatry |
| title | Cortical connectomic mediations on gamma band synchronization in schizophrenia |
| title_full | Cortical connectomic mediations on gamma band synchronization in schizophrenia |
| title_fullStr | Cortical connectomic mediations on gamma band synchronization in schizophrenia |
| title_full_unstemmed | Cortical connectomic mediations on gamma band synchronization in schizophrenia |
| title_short | Cortical connectomic mediations on gamma band synchronization in schizophrenia |
| title_sort | cortical connectomic mediations on gamma band synchronization in schizophrenia |
| url | https://doi.org/10.1038/s41398-022-02300-6 |
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