The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
Abstract. Introduction:. Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization. Objectives...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-09-01
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| Series: | PAIN Reports |
| Online Access: | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001098 |
| _version_ | 1797671737649790976 |
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| author | Juliane Sachau Dilara Kersebaum Philipp Hüllemann Daniela Adolf Maria Kabelitz Thomas Keller Rainer Freynhagen Thomas R. Tölle Andreas Binder Ralf Baron |
| author_facet | Juliane Sachau Dilara Kersebaum Philipp Hüllemann Daniela Adolf Maria Kabelitz Thomas Keller Rainer Freynhagen Thomas R. Tölle Andreas Binder Ralf Baron |
| author_sort | Juliane Sachau |
| collection | DOAJ |
| description | Abstract. Introduction:. Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization.
Objectives:. This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP.
Methods:. Within this cross-sectional study, data sets of 3339 patients with chronic NP syndromes (painful diabetic polyneuropathy, n = 543; postherpetic neuralgia, n = 1480) or complex regional pain syndromes (CRPS, n = 1316) were analyzed. Neuropathic pain symptoms were assessed with the painDETECT questionnaire (PD-Q), depression with the Patient Health Questionnaire-9, and sleep impairment with items of the Medical Outcomes Study Sleep Scale in 4 subscales. The association of demographic/clinical data, somatosensory phenotype, depression, and pain intensity with sleep impairment was assessed by unadjusted Spearman correlation analyses and multivariable regression analyses.
Results:. Sleep impairment was observed in all pain aetiologies although with some significant differences in the single sleep items. The intensity of the individual PD-Q items differed to some extent between the 3 pain entities, whereas the PD-Q sum score was similar. Thermal hyperalgesia and burning assessed by the PD-Q were significantly associated with sleep disturbance, adequacy, and quantity but not with sleep somnolence. Only depression and self-reported allodynia had a significant relation to all 4 sleep elements.
Conclusion:. Beside depression, allodynia as a surrogate marker hints to a possible impact of central sensitization on the sleep disruption of patients with NP. |
| first_indexed | 2024-03-11T21:19:53Z |
| format | Article |
| id | doaj.art-5af61c5e473143c39c83710fe51897a9 |
| institution | Directory Open Access Journal |
| issn | 2471-2531 |
| language | English |
| last_indexed | 2024-03-11T21:19:53Z |
| publishDate | 2023-09-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | PAIN Reports |
| spelling | doaj.art-5af61c5e473143c39c83710fe51897a92023-09-28T07:18:53ZengWolters KluwerPAIN Reports2471-25312023-09-0185e109810.1097/PR9.0000000000001098202309000-00011The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic painJuliane Sachau0Dilara Kersebaum1Philipp Hüllemann2Daniela Adolf3Maria Kabelitz4Thomas Keller5Rainer Freynhagen6Thomas R. Tölle7Andreas Binder8Ralf Baron9a Division of Pain Research and Therapy, Department of Neurology, University Hospital Kiel, Schleswig-Holstein, Kiel, Germanya Division of Pain Research and Therapy, Department of Neurology, University Hospital Kiel, Schleswig-Holstein, Kiel, Germanya Division of Pain Research and Therapy, Department of Neurology, University Hospital Kiel, Schleswig-Holstein, Kiel, Germanyc StatConsult GmbH, Magdeburg, Germanyc StatConsult GmbH, Magdeburg, Germanyc StatConsult GmbH, Magdeburg, Germanyd Department of Anaesthesiology, Critical Care Medicine and Pain Medicine, Benedictus Hospital Tutzing & Feldafing, Pain Center Lake Starnberg, Feldafing, Germanye Department of Neurology, Technische Universität München, Klinikum rechts der Isar, München, Germanya Division of Pain Research and Therapy, Department of Neurology, University Hospital Kiel, Schleswig-Holstein, Kiel, Germanya Division of Pain Research and Therapy, Department of Neurology, University Hospital Kiel, Schleswig-Holstein, Kiel, GermanyAbstract. Introduction:. Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization. Objectives:. This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP. Methods:. Within this cross-sectional study, data sets of 3339 patients with chronic NP syndromes (painful diabetic polyneuropathy, n = 543; postherpetic neuralgia, n = 1480) or complex regional pain syndromes (CRPS, n = 1316) were analyzed. Neuropathic pain symptoms were assessed with the painDETECT questionnaire (PD-Q), depression with the Patient Health Questionnaire-9, and sleep impairment with items of the Medical Outcomes Study Sleep Scale in 4 subscales. The association of demographic/clinical data, somatosensory phenotype, depression, and pain intensity with sleep impairment was assessed by unadjusted Spearman correlation analyses and multivariable regression analyses. Results:. Sleep impairment was observed in all pain aetiologies although with some significant differences in the single sleep items. The intensity of the individual PD-Q items differed to some extent between the 3 pain entities, whereas the PD-Q sum score was similar. Thermal hyperalgesia and burning assessed by the PD-Q were significantly associated with sleep disturbance, adequacy, and quantity but not with sleep somnolence. Only depression and self-reported allodynia had a significant relation to all 4 sleep elements. Conclusion:. Beside depression, allodynia as a surrogate marker hints to a possible impact of central sensitization on the sleep disruption of patients with NP.http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001098 |
| spellingShingle | Juliane Sachau Dilara Kersebaum Philipp Hüllemann Daniela Adolf Maria Kabelitz Thomas Keller Rainer Freynhagen Thomas R. Tölle Andreas Binder Ralf Baron The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain PAIN Reports |
| title | The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain |
| title_full | The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain |
| title_fullStr | The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain |
| title_full_unstemmed | The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain |
| title_short | The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain |
| title_sort | association of self reported symptoms of central sensitization and sleep disturbances in neuropathic pain |
| url | http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001098 |
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