Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis
Furan (C4H4O) is a naturally occurring organic compound. It develops as a result of the thermal processing of food and stimulates critical impairments in male reproductive tract. Eriodictyol (Etyol) is a natural dietary flavonoid possessing diverse pharmacological potentials. The recent investigatio...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323005079 |
| _version_ | 1797812794890911744 |
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| author | Muhammad Umar Ijaz Shama Mustafa Qurat Ul Ain Ali Hamza Hussain Ahmed Mohamed M. Abdel-Daim Ghadeer M. Albadrani Agnieszka Najda Shafaqat Ali |
| author_facet | Muhammad Umar Ijaz Shama Mustafa Qurat Ul Ain Ali Hamza Hussain Ahmed Mohamed M. Abdel-Daim Ghadeer M. Albadrani Agnieszka Najda Shafaqat Ali |
| author_sort | Muhammad Umar Ijaz |
| collection | DOAJ |
| description | Furan (C4H4O) is a naturally occurring organic compound. It develops as a result of the thermal processing of food and stimulates critical impairments in male reproductive tract. Eriodictyol (Etyol) is a natural dietary flavonoid possessing diverse pharmacological potentials. The recent investigation was proposed to ascertain the ameliorative potential of eriodictyol against furan-instigated reproductive dysfunctions. Male rats (n = 48) were classified into 4 groups: untreated/control, furan (10 mg/kg), furan+ eriodictyol (10 mg/kg + 20 mg/kg) and eriodictyol (20 mg/kg). At the 56th day of the trial, the protective effects of eriodictyol were evaluated by assessing various parameters. Results of the study revealed that eriodictyol attenuated furan-induced testicular toxicity in the biochemical profile by increasing catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) along with glutathione reductase (GSR) activities, whereas reduced the reactive oxygen species (ROS) along with malondialdehyde (MDA) levels. It also restored the normal state of sperm motility, viability, the count of hypo-osmotic tail swelled sperm as well as epididymal sperm number along with reduced sperm anomalies (morphological) tail, mid-piece and head. Furthermore, it elevated the decreased levels of luteinizing hormone (LH), plasma testosterone and follicle-stimulating hormone (FSH) as well steroidogenic enzymes (17β-HSD, StAR protein & 3β-HSD) and testicular anti-apoptotic marker (Bcl-2) expression, whereas, down-regulating apoptotic markers (Bax & Caspase-3) expression. Eriodictyol treatment also effectively mitigated the histopathological damages. The outcomes of the current study provide fundamental insights into the ameliorative potential of eriodictyol against furan-instigated testicular toxicity. |
| first_indexed | 2024-03-13T07:43:44Z |
| format | Article |
| id | doaj.art-5af7748fd5034d2b8135366bd60e178f |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-13T07:43:44Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-5af7748fd5034d2b8135366bd60e178f2023-06-03T04:21:24ZengElsevierEcotoxicology and Environmental Safety0147-65132023-07-01259115003Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosisMuhammad Umar Ijaz0Shama Mustafa1Qurat Ul Ain2Ali Hamza3Hussain Ahmed4Mohamed M. Abdel-Daim5Ghadeer M. Albadrani6Agnieszka Najda7Shafaqat Ali8Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, Government College Women University, Sialkot, PakistanDepartment of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad, PakistanDepartment of Zoology, The University of Buner, Khyber Pakhtunkhwa, PakistanDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt; Corresponding author at: Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia.Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, 84428, Riyadh 11671, Saudi ArabiaDepartment of Vegetable Crops and Medicinal Plants University of Life Sciences in Lublin, 50A Doświadczalna Street, 20–280 Lublin, PolandDepartment of Environmental Sciences, Government College University, 38000, Faisalabad, Pakistan; Department of Biological Sciences and Technology, China Medical University, Taichung 40402, Taiwan; Corresponding author at:: Department of Environmental Sciences, Government College University, 38000, Faisalabad, Pakistan.Furan (C4H4O) is a naturally occurring organic compound. It develops as a result of the thermal processing of food and stimulates critical impairments in male reproductive tract. Eriodictyol (Etyol) is a natural dietary flavonoid possessing diverse pharmacological potentials. The recent investigation was proposed to ascertain the ameliorative potential of eriodictyol against furan-instigated reproductive dysfunctions. Male rats (n = 48) were classified into 4 groups: untreated/control, furan (10 mg/kg), furan+ eriodictyol (10 mg/kg + 20 mg/kg) and eriodictyol (20 mg/kg). At the 56th day of the trial, the protective effects of eriodictyol were evaluated by assessing various parameters. Results of the study revealed that eriodictyol attenuated furan-induced testicular toxicity in the biochemical profile by increasing catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) along with glutathione reductase (GSR) activities, whereas reduced the reactive oxygen species (ROS) along with malondialdehyde (MDA) levels. It also restored the normal state of sperm motility, viability, the count of hypo-osmotic tail swelled sperm as well as epididymal sperm number along with reduced sperm anomalies (morphological) tail, mid-piece and head. Furthermore, it elevated the decreased levels of luteinizing hormone (LH), plasma testosterone and follicle-stimulating hormone (FSH) as well steroidogenic enzymes (17β-HSD, StAR protein & 3β-HSD) and testicular anti-apoptotic marker (Bcl-2) expression, whereas, down-regulating apoptotic markers (Bax & Caspase-3) expression. Eriodictyol treatment also effectively mitigated the histopathological damages. The outcomes of the current study provide fundamental insights into the ameliorative potential of eriodictyol against furan-instigated testicular toxicity.http://www.sciencedirect.com/science/article/pii/S0147651323005079FuranEriodictyolOxidative stress markersApoptosis markersSteroidogenesis |
| spellingShingle | Muhammad Umar Ijaz Shama Mustafa Qurat Ul Ain Ali Hamza Hussain Ahmed Mohamed M. Abdel-Daim Ghadeer M. Albadrani Agnieszka Najda Shafaqat Ali Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis Ecotoxicology and Environmental Safety Furan Eriodictyol Oxidative stress markers Apoptosis markers Steroidogenesis |
| title | Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis |
| title_full | Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis |
| title_fullStr | Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis |
| title_full_unstemmed | Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis |
| title_short | Eriodictyol attenuates Furan induced testicular toxicity in Rats: Role of oxidative stress, steroidogenic enzymes and apoptosis |
| title_sort | eriodictyol attenuates furan induced testicular toxicity in rats role of oxidative stress steroidogenic enzymes and apoptosis |
| topic | Furan Eriodictyol Oxidative stress markers Apoptosis markers Steroidogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323005079 |
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