Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes
Abstract Objective Many different genetic variants of proprotein convertase subtilisin kexin 9 (PCSK9) are related to the serum levels of cholesterol and LDL cholesterol (LDL-C). The rs615563 variant of PCSK9 (a gain-of-function mutation) is associated with increased triglycerides and cholesterol le...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-021-05723-4 |
| _version_ | 1819094720451706880 |
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| author | Samira Taghizadeh Jazdani Hajieh Bibi Shahbazian Bahman Cheraghian Mohammad Taha Jalali Narges Mohammadtaghvaei |
| author_facet | Samira Taghizadeh Jazdani Hajieh Bibi Shahbazian Bahman Cheraghian Mohammad Taha Jalali Narges Mohammadtaghvaei |
| author_sort | Samira Taghizadeh Jazdani |
| collection | DOAJ |
| description | Abstract Objective Many different genetic variants of proprotein convertase subtilisin kexin 9 (PCSK9) are related to the serum levels of cholesterol and LDL cholesterol (LDL-C). The rs615563 variant of PCSK9 (a gain-of-function mutation) is associated with increased triglycerides and cholesterol levels, but its association with the incidence of diabetes is not well defined. This study aimed to investigate the relationship between the PCSK9 rs615563 variant with the incidence of type 2 diabetes. The data reported in this study are based on subsamples from a 5-year (2009–2014) cohort study of the adult population (590 subjects) aged 20 years and older. The rs615563 polymorphism was genotyped using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis. Results The distribution of PCSK9 rs615563 genotypes was not significantly different between the diabetic and non-diabetic individuals. The incidence of diabetes after five-years of follow-up was not different between the genotypes. Our findings also showed no significant relationship between this polymorphism and serum lipid parameters. The data extracted from our cohort study do not support the findings that the gain-of-function mutations of PCSK9 predispose to the incidence of type 2 diabetes. |
| first_indexed | 2024-12-21T23:31:53Z |
| format | Article |
| id | doaj.art-5af91e5184a04421961b1261cb68669c |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-21T23:31:53Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-5af91e5184a04421961b1261cb68669c2022-12-21T18:46:28ZengBMCBMC Research Notes1756-05002021-08-011411610.1186/s13104-021-05723-4Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetesSamira Taghizadeh Jazdani0Hajieh Bibi Shahbazian1Bahman Cheraghian2Mohammad Taha Jalali3Narges Mohammadtaghvaei4Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical SciencesHealth Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Health, Ahvaz Jundishapur University of Medical SciencesDepartment of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Laboratory Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical SciencesAbstract Objective Many different genetic variants of proprotein convertase subtilisin kexin 9 (PCSK9) are related to the serum levels of cholesterol and LDL cholesterol (LDL-C). The rs615563 variant of PCSK9 (a gain-of-function mutation) is associated with increased triglycerides and cholesterol levels, but its association with the incidence of diabetes is not well defined. This study aimed to investigate the relationship between the PCSK9 rs615563 variant with the incidence of type 2 diabetes. The data reported in this study are based on subsamples from a 5-year (2009–2014) cohort study of the adult population (590 subjects) aged 20 years and older. The rs615563 polymorphism was genotyped using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis. Results The distribution of PCSK9 rs615563 genotypes was not significantly different between the diabetic and non-diabetic individuals. The incidence of diabetes after five-years of follow-up was not different between the genotypes. Our findings also showed no significant relationship between this polymorphism and serum lipid parameters. The data extracted from our cohort study do not support the findings that the gain-of-function mutations of PCSK9 predispose to the incidence of type 2 diabetes.https://doi.org/10.1186/s13104-021-05723-4Type 2 diabetesLDL cholesterolrs615563PCSK9PCR–RFLP |
| spellingShingle | Samira Taghizadeh Jazdani Hajieh Bibi Shahbazian Bahman Cheraghian Mohammad Taha Jalali Narges Mohammadtaghvaei Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes BMC Research Notes Type 2 diabetes LDL cholesterol rs615563 PCSK9 PCR–RFLP |
| title | Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes |
| title_full | Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes |
| title_fullStr | Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes |
| title_full_unstemmed | Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes |
| title_short | Association between the rs615563 variant of PCSK9 gene and circulating lipids and Type 2 diabetes |
| title_sort | association between the rs615563 variant of pcsk9 gene and circulating lipids and type 2 diabetes |
| topic | Type 2 diabetes LDL cholesterol rs615563 PCSK9 PCR–RFLP |
| url | https://doi.org/10.1186/s13104-021-05723-4 |
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