Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters
This study examined the antibacterial effects and physical properties of a novel resin composite incorporating poly[{2-(methacryloyloxy)ethyl}trimethylammonium chloride] (poly(METAC)), a methacrylate cationic polymer comprising quaternary ammonium compounds (QACs). Resin composites incorporating pol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/17/4/896 |
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| author | Tomoki Kohno Haruaki Kitagawa Ririko Tsuboi Fan Deng Hirohiko Sakai Tingyi Wu Yo-Shiuan Fan Linghao Xiao Satoshi Imazato |
| author_facet | Tomoki Kohno Haruaki Kitagawa Ririko Tsuboi Fan Deng Hirohiko Sakai Tingyi Wu Yo-Shiuan Fan Linghao Xiao Satoshi Imazato |
| author_sort | Tomoki Kohno |
| collection | DOAJ |
| description | This study examined the antibacterial effects and physical properties of a novel resin composite incorporating poly[{2-(methacryloyloxy)ethyl}trimethylammonium chloride] (poly(METAC)), a methacrylate cationic polymer comprising quaternary ammonium compounds (QACs). Resin composites incorporating poly(METAC) were fabricated by adding 6 wt.% METAC aqueous solution to a commercially available resin composite. The FE-SEM/EDS and Raman spec-troscopy analyses showed that METAC was assembled and polymerized in the resin composites after curing. The antibacterial effect was evaluated by inoculating Streptococcus mutans or Strepto-coccus sobrinus suspensions on the surface of cured resin composites, and the experimental resin composites incorporating poly(METAC) clusters exhibited bactericidal effects even after 28 days of ageing. The physical properties of the experimental resin composites were within the ISO-stipulated ranges. Newly fabricated resin composites containing the QAC-based poly(METAC) cluster ex-hibited long-term bactericidal effects against oral bacteria on their surfaces and demonstrated ac-ceptable physical properties for clinical use. |
| first_indexed | 2024-03-07T22:22:47Z |
| format | Article |
| id | doaj.art-5af978f178b44689a1891a217f24cb15 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-07T22:22:47Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-5af978f178b44689a1891a217f24cb152024-02-23T15:25:43ZengMDPI AGMaterials1996-19442024-02-0117489610.3390/ma17040896Development of Antibacterial Resin Composites Incorporating Poly(METAC) ClustersTomoki Kohno0Haruaki Kitagawa1Ririko Tsuboi2Fan Deng3Hirohiko Sakai4Tingyi Wu5Yo-Shiuan Fan6Linghao Xiao7Satoshi Imazato8Joint Research Laboratory of Advanced Functional Materials Science, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanJoint Research Laboratory of Advanced Functional Materials Science, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI 48109, USADepartment of Dental Biomaterials, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Dental Biomaterials, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Dental Biomaterials, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanDepartment of Dental Biomaterials, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanJoint Research Laboratory of Advanced Functional Materials Science, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanJoint Research Laboratory of Advanced Functional Materials Science, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, JapanThis study examined the antibacterial effects and physical properties of a novel resin composite incorporating poly[{2-(methacryloyloxy)ethyl}trimethylammonium chloride] (poly(METAC)), a methacrylate cationic polymer comprising quaternary ammonium compounds (QACs). Resin composites incorporating poly(METAC) were fabricated by adding 6 wt.% METAC aqueous solution to a commercially available resin composite. The FE-SEM/EDS and Raman spec-troscopy analyses showed that METAC was assembled and polymerized in the resin composites after curing. The antibacterial effect was evaluated by inoculating Streptococcus mutans or Strepto-coccus sobrinus suspensions on the surface of cured resin composites, and the experimental resin composites incorporating poly(METAC) clusters exhibited bactericidal effects even after 28 days of ageing. The physical properties of the experimental resin composites were within the ISO-stipulated ranges. Newly fabricated resin composites containing the QAC-based poly(METAC) cluster ex-hibited long-term bactericidal effects against oral bacteria on their surfaces and demonstrated ac-ceptable physical properties for clinical use.https://www.mdpi.com/1996-1944/17/4/896antibacterial resin compositeMETACquaternary ammonium compounds |
| spellingShingle | Tomoki Kohno Haruaki Kitagawa Ririko Tsuboi Fan Deng Hirohiko Sakai Tingyi Wu Yo-Shiuan Fan Linghao Xiao Satoshi Imazato Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters Materials antibacterial resin composite METAC quaternary ammonium compounds |
| title | Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters |
| title_full | Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters |
| title_fullStr | Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters |
| title_full_unstemmed | Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters |
| title_short | Development of Antibacterial Resin Composites Incorporating Poly(METAC) Clusters |
| title_sort | development of antibacterial resin composites incorporating poly metac clusters |
| topic | antibacterial resin composite METAC quaternary ammonium compounds |
| url | https://www.mdpi.com/1996-1944/17/4/896 |
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