Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure
Chagas cardiomyopathy (CC), caused by the protozoan <i>Trypanosoma cruzi</i>, is an important cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 to 7 million people worldwide are infected, and it is predicted that it will be responsible for 20...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/24/7262 |
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| author | Isis G. Montalvo-Ocotoxtle Gustavo Rojas-Velasco Olivia Rodríguez-Morales Minerva Arce-Fonseca Luis A. Baeza-Herrera Arturo Arzate-Ramírez Gabriela Meléndez-Ramírez Daniel Manzur-Sandoval Mayra L. Lara-Romero Antonio Reyes-Ortega Patricia Espinosa-González Erika Palacios-Rosas |
| author_facet | Isis G. Montalvo-Ocotoxtle Gustavo Rojas-Velasco Olivia Rodríguez-Morales Minerva Arce-Fonseca Luis A. Baeza-Herrera Arturo Arzate-Ramírez Gabriela Meléndez-Ramírez Daniel Manzur-Sandoval Mayra L. Lara-Romero Antonio Reyes-Ortega Patricia Espinosa-González Erika Palacios-Rosas |
| author_sort | Isis G. Montalvo-Ocotoxtle |
| collection | DOAJ |
| description | Chagas cardiomyopathy (CC), caused by the protozoan <i>Trypanosoma cruzi</i>, is an important cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 to 7 million people worldwide are infected, and it is predicted that it will be responsible for 200,000 deaths by 2025. The World Health Organization (WHO) considers Chagas disease (CD) as a Neglected Tropical Disease (NTD), which must be acknowledged and detected in time, as it remains a clinical and diagnostic challenge in both endemic and non-endemic regions and at different levels of care. The literature on CC was analyzed by searching different databases (Medline, Cochrane Central, EMBASE, PubMed, Google Scholar, EBSCO) from 1968 until October 2022. Multicenter and bioinformatics trials, systematic and bibliographic reviews, international guidelines, and clinical cases were included. The reference lists of the included papers were checked. No linguistic restrictions or study designs were applied. This review is intended to address the current incidence and prevalence of CD and to identify the main pathogenic mechanisms, clinical presentation, and diagnosis of CC. |
| first_indexed | 2024-03-09T16:16:47Z |
| format | Article |
| id | doaj.art-5afb0c14e784422e98a2fcd7d93effcc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:16:47Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5afb0c14e784422e98a2fcd7d93effcc2023-11-24T15:42:31ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011124726210.3390/jcm11247262Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart FailureIsis G. Montalvo-Ocotoxtle0Gustavo Rojas-Velasco1Olivia Rodríguez-Morales2Minerva Arce-Fonseca3Luis A. Baeza-Herrera4Arturo Arzate-Ramírez5Gabriela Meléndez-Ramírez6Daniel Manzur-Sandoval7Mayra L. Lara-Romero8Antonio Reyes-Ortega9Patricia Espinosa-González10Erika Palacios-Rosas11Cardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoCardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartment of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoCardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoCardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoMagnetic Resonance Imaging Department, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoCardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoAcademic Department of Health Sciences, School of Sciences, Universidad de las Américas Puebla, Ex Hacienda Sta. Catarina Mártir S/N. San Andrés Cholula, Puebla 72810, MexicoCardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoCardiovascular Critical Care Unit, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Mexico City 14080, MexicoAcademic Department of Health Sciences, School of Sciences, Universidad de las Américas Puebla, Ex Hacienda Sta. Catarina Mártir S/N. San Andrés Cholula, Puebla 72810, MexicoChagas cardiomyopathy (CC), caused by the protozoan <i>Trypanosoma cruzi</i>, is an important cause of cardiovascular morbidity and mortality in developing countries. It is estimated that 6 to 7 million people worldwide are infected, and it is predicted that it will be responsible for 200,000 deaths by 2025. The World Health Organization (WHO) considers Chagas disease (CD) as a Neglected Tropical Disease (NTD), which must be acknowledged and detected in time, as it remains a clinical and diagnostic challenge in both endemic and non-endemic regions and at different levels of care. The literature on CC was analyzed by searching different databases (Medline, Cochrane Central, EMBASE, PubMed, Google Scholar, EBSCO) from 1968 until October 2022. Multicenter and bioinformatics trials, systematic and bibliographic reviews, international guidelines, and clinical cases were included. The reference lists of the included papers were checked. No linguistic restrictions or study designs were applied. This review is intended to address the current incidence and prevalence of CD and to identify the main pathogenic mechanisms, clinical presentation, and diagnosis of CC.https://www.mdpi.com/2077-0383/11/24/7262Chagas diseaseChagas cardiomyopathy (CC)chronic Chagas cardiomyopathy (CCC)myocarditisheart failure |
| spellingShingle | Isis G. Montalvo-Ocotoxtle Gustavo Rojas-Velasco Olivia Rodríguez-Morales Minerva Arce-Fonseca Luis A. Baeza-Herrera Arturo Arzate-Ramírez Gabriela Meléndez-Ramírez Daniel Manzur-Sandoval Mayra L. Lara-Romero Antonio Reyes-Ortega Patricia Espinosa-González Erika Palacios-Rosas Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure Journal of Clinical Medicine Chagas disease Chagas cardiomyopathy (CC) chronic Chagas cardiomyopathy (CCC) myocarditis heart failure |
| title | Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure |
| title_full | Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure |
| title_fullStr | Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure |
| title_full_unstemmed | Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure |
| title_short | Chagas Heart Disease: Beyond a Single Complication, from Asymptomatic Disease to Heart Failure |
| title_sort | chagas heart disease beyond a single complication from asymptomatic disease to heart failure |
| topic | Chagas disease Chagas cardiomyopathy (CC) chronic Chagas cardiomyopathy (CCC) myocarditis heart failure |
| url | https://www.mdpi.com/2077-0383/11/24/7262 |
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