Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway

Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway

AIM: To test our hypothesis that activation of protein kinase A (PKA) signal pathway by β-adrenergic agonist plays an important role in the protecting of cultured retinal pigment epithelial (RPE) cells against the hydroxychloroquine (HCQ) toxicity. METHODS: Cultured human RPE cells were treated wit...

Full description

Bibliographic Details
Main Authors:	Ruihua Zhang, Dan-Ning Hu, Richard Rosen
Format:	Article
Language:	English
Published:	Press of International Journal of Ophthalmology (IJO PRESS) 2020-04-01
Series:	International Journal of Ophthalmology
Subjects:	hydroxycholoroquine retinal pigment epithelial cells retinopathy protein kinase a vacuolation
Online Access:	http://www.ijo.cn/en_publish/2020/4/20200404.pdf

Similar Items

Healing pattern of subfoveal retinal pigment epithelium rip and aperture in central serous chorioretinopathy
by: George Joseph Manayath, et al.
Published: (2023-01-01)

Functions and Diseases of the Retinal Pigment Epithelium
by: Song Yang, et al.
Published: (2021-07-01)

Autophagy dysregulation mediates the damage of high glucose to retinal pigment epithelium cells
by: Qian Zhang, et al.
Published: (2021-06-01)

Exudative retinal detachment and retinal pigment epithelial rip due to central serous retinopathy in eye with diabetic retinopathy
by: Kumar Saurabh, et al.
Published: (2017-01-01)

Culture of Retinal Pigment Epithelium from Evisceration Specimens
by: Han-Yi Tseng, et al.
Published: (2004-05-01)

Immunomodulation and Reduction of Thromboembolic Risk in Hospitalized COVID-19 Patients: Systematic Review and Meta-Analysis of Randomized Trials
by: Dimitrios Sagris, et al.
Published: (2021-11-01)

Spontaneous Large Serous Retinal Pigment Epithelial Tear
by: Voraporn Chaikitmongkol, et al.
Published: (2012-10-01)

Research progress of LncRNA in retinal pigment epithelium associated retinal diseases
by: Zi-Yan Tang, et al.
Published: (2019-08-01)

Regulation of epithelial-mesenchymal transition in retinal pigment epithelium and its associated cellular signaling cascades: an updated review
by: Brijesh Gelat, et al.
Published: (2023-10-01)

High glucose on the expression of N-cadherin and fibronectin in retinal pigment epithelium cells
by: Wen-Jiao Bi, et al.
Published: (2014-09-01)

Suppression of cAMP/PKA/CREB signaling ameliorates retinal injury in diabetic retinopathy
by: Xiao‐Ling Fang, et al.
Published: (2023-09-01)

Ruptured unilateral anterior lenticonus with congenital hypertrophy of retinal pigment epithelium: A rare association
by: Kirandeep Kaur, et al.
Published: (2020-01-01)

Foveal simple hamartoma of retinal pigment epithelium
by: Prabu Baskaran, et al.
Published: (2018-01-01)

Serpentine retinal pigment epithelial tear
by: Aditya Maitray, et al.
Published: (2021-01-01)

The thickness and volume of the choroid, outer retinal layers and retinal pigment epithelium layer changes in patients with diabetic retinopathy
by: Xiang-Ning Wang, et al.
Published: (2018-12-01)

Common clinical features of unilateral retinal pigment epithelium dysgenesis and combined hamartoma of the retina and retinal pigment epithelium
by: Zhe Zhu, et al.
Published: (2022-01-01)

Progress of inhibiting epithelial-mesenchymal transition in retinal pigment epithelial cells
by: Duo Li, et al.
Published: (2018-12-01)

A Case of Giant Macular Hole Progression after Rupture of a Giant Retinal Pigment Epithelial Detachment
by: Kosuke Nagaoka, et al.
Published: (2019-06-01)

Polyphenol Metabolite Pyrogallol-<i>O</i>-Sulfate Decreases Microglial Activation and VEGF in Retinal Pigment Epithelium Cells and Diabetic Mouse Retina
by: Daniela F. Santos, et al.
Published: (2021-10-01)

The Benefits of the Citrus Flavonoid Diosmin on Human Retinal Pigment Epithelial Cells under High-Glucose Conditions
by: Wayne Young Liu, et al.
Published: (2017-12-01)

Influence of ultraviolet A radiation on osmolytes transport in human retinal pigment epithelial cells
by: Da-Yang Wu, et al.
Published: (2014-04-01)

Protective roles of autophagy in retinal pigment epithelium under high glucose condition via regulating PINK1/Parkin pathway and BNIP3L
by: Chengchi Huang, et al.
Published: (2018-07-01)

Transcriptional comparison of adult human primary Retinal Pigment Epithelium, human pluripotent stem cell-derived Retinal Pigment Epithelium, and ARPE19 cells
by: Elke K. Markert, et al.
Published: (2022-08-01)

1,8-Cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via PPAR-γ/TXNIP pathways
by: Zhangnian Liu, et al.
Published: (2023-08-01)

Concentric retinal pigment epithelium tear in central serous chorioretinopathy
by: Darshana Daga, et al.
Published: (2019-01-01)

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration
by: Jinying Li, et al.
Published: (2021-09-01)

Reticular Dystrophy of the Retinal Pigment Epithelium
by: Muh-Shy Chen, et al.
Published: (2007-01-01)

Role and mechanism of NTR p75 receptor in oxidative damage of retinal pigment epithelium cells
by: Xin Gu, et al.
Published: (2018-01-01)

Recent advances of morphogenesis and development in retinal pigment epithelium
by: Yan Zhang, et al.
Published: (2014-03-01)

Retinal Pigment Epithelium Transplantation: Past, Present, and Future
by: Ayyad Zartasht Khan, et al.
Published: (2022-11-01)

TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy
by: Liangjing Wu, et al.
Published: (2022-12-01)

Chordin-like 2 influences the differentiation fate of retinal pigment epithelium cells by dynamically regulating BMP pathway
by: Duo Li, et al.
Published: (2022-05-01)

An unusual case of congenital hypertrophy of retinal pigment epithelium with overlying hemorrhages
by: Rohan Chawla, et al.
Published: (2016-01-01)

<i>Osteomeles schwerinae</i> Extract and Its Major Compounds Inhibit Methylglyoxal-Induced Apoptosis in Human Retinal Pigment Epithelial Cells
by: Bo-Jeong Pyun, et al.
Published: (2020-06-01)

Bruch’s-Mimetic Nanofibrous Membranes Functionalized with the Integrin-Binding Peptides as a Promising Approach for Human Retinal Pigment Epithelium Cell Transplantation
by: Shaocheng Wang, et al.
Published: (2022-02-01)

The association between plasma concentration of pigment epithelium-derived factor and diabetic retinopathy
by: Şahin Tayfun, et al.
Published: (2023-09-01)

Potential therapeutic effects of pigment epithelium-derived factor for treatment of diabetic retinopathy
by: Xiao Liu, et al.
Published: (2013-04-01)

External Limiting Membrane, Photoreceptor Ellipsoid Zone Disruption, and Retinal Pigment Epithelium Alterations in Diabetic Retinopathy
by: Nibha Mishra, et al.
Published: (2022-07-01)

Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes
by: Yan Levitsky, et al.
Published: (2020-05-01)

Pigment Epithelium‐Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF‐R)
by: Peng Lu, et al.
Published: (2016-07-01)