Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06949-w |
| _version_ | 1818420001058586624 |
|---|---|
| author | Carman K. M. Ip Patrick K. S. Ng Kang Jin Jeong S. H. Shao Zhenlin Ju P. G. Leonard Xu Hua Christopher P. Vellano Richard Woessner Nidhi Sahni Kenneth L. Scott Gordon B. Mills |
| author_facet | Carman K. M. Ip Patrick K. S. Ng Kang Jin Jeong S. H. Shao Zhenlin Ju P. G. Leonard Xu Hua Christopher P. Vellano Richard Woessner Nidhi Sahni Kenneth L. Scott Gordon B. Mills |
| author_sort | Carman K. M. Ip |
| collection | DOAJ |
| description | Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation is resistant to PDGFRA targeted therapies. |
| first_indexed | 2024-12-14T12:47:31Z |
| format | Article |
| id | doaj.art-5afbb5f4318a4d348864297344880429 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:47:31Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5afbb5f4318a4d3488642973448804292022-12-21T23:00:45ZengNature PortfolioNature Communications2041-17232018-11-019111410.1038/s41467-018-06949-wNeomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapiesCarman K. M. Ip0Patrick K. S. Ng1Kang Jin Jeong2S. H. Shao3Zhenlin Ju4P. G. Leonard5Xu Hua6Christopher P. Vellano7Richard Woessner8Nidhi Sahni9Kenneth L. Scott10Gordon B. Mills11Department of Systems Biology, The University of Texas MD Anderson Cancer CenterSheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterSheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer CenterDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer CenterInstitute for Applied Cancer Science, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterCenter for Co-Clinical Trials, The University of Texas MD Anderson Cancer CenterCancer Bioscience, in vivo Cancer Pharmacology, AstraZeneca PhamaceuticalsDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterDan L. Duncan Cancer Center, Baylor College of MedicineDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterActivation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomorphic PDGFRA extracellular domain driver mutation is resistant to PDGFRA targeted therapies.https://doi.org/10.1038/s41467-018-06949-w |
| spellingShingle | Carman K. M. Ip Patrick K. S. Ng Kang Jin Jeong S. H. Shao Zhenlin Ju P. G. Leonard Xu Hua Christopher P. Vellano Richard Woessner Nidhi Sahni Kenneth L. Scott Gordon B. Mills Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies Nature Communications |
| title | Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies |
| title_full | Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies |
| title_fullStr | Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies |
| title_full_unstemmed | Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies |
| title_short | Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies |
| title_sort | neomorphic pdgfra extracellular domain driver mutations are resistant to pdgfra targeted therapies |
| url | https://doi.org/10.1038/s41467-018-06949-w |
| work_keys_str_mv | AT carmankmip neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT patrickksng neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT kangjinjeong neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT shshao neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT zhenlinju neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT pgleonard neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT xuhua neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT christopherpvellano neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT richardwoessner neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT nidhisahni neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT kennethlscott neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies AT gordonbmills neomorphicpdgfraextracellulardomaindrivermutationsareresistanttopdgfratargetedtherapies |