BK<sub>Ca</sub> Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia

BK<sub>Ca</sub> Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia

This study explored whether KMUP-1 improved chronic constriction injury (CCI)-induced BK<sub>Ca</sub> current inhibition in dorsal root ganglion (DRG) neurons. Rats were randomly assigned to four groups: sham, sham + KMUP-1, CCI, and CCI + KMUP-1 (5 mg/kg/day, i.p.). DRG neuronal cells (...

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Bibliographic Details
Main Authors: Kuang-I Cheng, Kan-Ting Yang, Chien-Lun Kung, Yu-Chi Cheng, Jwu-Lai Yeh, Zen-Kong Dai, Bin-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
KMUP-1
chronic constriction injury
dorsal root ganglion
perforated patch-clamp
BK<sub>Ca</sub> currents
immunofluorescent staining
Online Access:https://www.mdpi.com/2073-4409/10/4/949

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