Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan
Jörg Mahlich,1,2 Rosarin Sruamsiri1,3 1Health Economics, Janssen Pharmaceutical KK, Tokyo, Japan; 2Düsseldorf Institute for Competition Economics (DICE), University of Düsseldorf, Düsseldorf, Germany; 3Center of Pharmaceutical Outcomes Research, Department of Pha...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-08-01
|
| Series: | Patient Preference and Adherence |
| Subjects: | |
| Online Access: | https://www.dovepress.com/persistence-with-biologic-agents-for-the-treatment-of-rheumatoid-arthr-peer-reviewed-article-PPA |
| _version_ | 1811311790555922432 |
|---|---|
| author | Mahlich J Sruamsiri R |
| author_facet | Mahlich J Sruamsiri R |
| author_sort | Mahlich J |
| collection | DOAJ |
| description | Jörg Mahlich,1,2 Rosarin Sruamsiri1,3 1Health Economics, Janssen Pharmaceutical KK, Tokyo, Japan; 2Düsseldorf Institute for Competition Economics (DICE), University of Düsseldorf, Düsseldorf, Germany; 3Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand Background: To assess persistence rates of biologic agents for the treatment of rheumatoid arthritis in Japan.Methods: Based on Japanese claims data of 16,214 patients between 2012 and 2014, 6-, 12-, and 18-month persistence rates of different biologic agents were calculated. Determinants of persistence were assessed by means of a multivariate Cox proportional hazard model controlling for age, sex, and comorbidities. A sensitivity analysis was performed with different definitions of persistence and parametric survival analysis.Results: Overall persistence rates in Japan are high and reach 86% after 1 year in the entire sample. The persistence rate for the biologic-naïve subpopulation is above 95%. Persistence is higher for older patients (hazard ratio 0.60 [95% confidence interval 0.40–0.91] for >75 years compared to ≤60 years) and lower for patients with a high comorbidity score (hazard ratio 1.33; 95% confidence interval 1.03–1.70 for Charlson Comorbidity Index score 3–5 compared to ≤2). We found a high variation of persistence between different drugs.Conclusion: Japanese rheumatoid arthritis patients have a high persistence rate of biologic treatments. However, multiple factors affect the persistence rate of Japanese patients, including age, comorbidities, and patient type. Naïve patients tend to have a higher persistence rate than continuing biologic patients. Keywords: Japan, rheumatoid arthritis, database analysis, persistence, biologics |
| first_indexed | 2024-04-13T10:25:03Z |
| format | Article |
| id | doaj.art-5affa86cb2484e72a577f7414b7f379c |
| institution | Directory Open Access Journal |
| issn | 1177-889X |
| language | English |
| last_indexed | 2024-04-13T10:25:03Z |
| publishDate | 2016-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj.art-5affa86cb2484e72a577f7414b7f379c2022-12-22T02:50:20ZengDove Medical PressPatient Preference and Adherence1177-889X2016-08-012016Issue 11509151928276Persistence with biologic agents for the treatment of rheumatoid arthritis in JapanMahlich JSruamsiri RJörg Mahlich,1,2 Rosarin Sruamsiri1,3 1Health Economics, Janssen Pharmaceutical KK, Tokyo, Japan; 2Düsseldorf Institute for Competition Economics (DICE), University of Düsseldorf, Düsseldorf, Germany; 3Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand Background: To assess persistence rates of biologic agents for the treatment of rheumatoid arthritis in Japan.Methods: Based on Japanese claims data of 16,214 patients between 2012 and 2014, 6-, 12-, and 18-month persistence rates of different biologic agents were calculated. Determinants of persistence were assessed by means of a multivariate Cox proportional hazard model controlling for age, sex, and comorbidities. A sensitivity analysis was performed with different definitions of persistence and parametric survival analysis.Results: Overall persistence rates in Japan are high and reach 86% after 1 year in the entire sample. The persistence rate for the biologic-naïve subpopulation is above 95%. Persistence is higher for older patients (hazard ratio 0.60 [95% confidence interval 0.40–0.91] for >75 years compared to ≤60 years) and lower for patients with a high comorbidity score (hazard ratio 1.33; 95% confidence interval 1.03–1.70 for Charlson Comorbidity Index score 3–5 compared to ≤2). We found a high variation of persistence between different drugs.Conclusion: Japanese rheumatoid arthritis patients have a high persistence rate of biologic treatments. However, multiple factors affect the persistence rate of Japanese patients, including age, comorbidities, and patient type. Naïve patients tend to have a higher persistence rate than continuing biologic patients. Keywords: Japan, rheumatoid arthritis, database analysis, persistence, biologicshttps://www.dovepress.com/persistence-with-biologic-agents-for-the-treatment-of-rheumatoid-arthr-peer-reviewed-article-PPAJapanRheumatoid arthritisDatabase AnalysisPersistenceBiologics |
| spellingShingle | Mahlich J Sruamsiri R Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan Patient Preference and Adherence Japan Rheumatoid arthritis Database Analysis Persistence Biologics |
| title | Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan |
| title_full | Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan |
| title_fullStr | Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan |
| title_full_unstemmed | Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan |
| title_short | Persistence with biologic agents for the treatment of rheumatoid arthritis in Japan |
| title_sort | persistence with biologic agents for the treatment of rheumatoid arthritis in japan |
| topic | Japan Rheumatoid arthritis Database Analysis Persistence Biologics |
| url | https://www.dovepress.com/persistence-with-biologic-agents-for-the-treatment-of-rheumatoid-arthr-peer-reviewed-article-PPA |
| work_keys_str_mv | AT mahlichj persistencewithbiologicagentsforthetreatmentofrheumatoidarthritisinjapan AT sruamsirir persistencewithbiologicagentsforthetreatmentofrheumatoidarthritisinjapan |