Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint
The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammator...
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MDPI AG
2022-12-01
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| author | Talha Bin Emran Fahadul Islam Nikhil Nath Hriday Sutradhar Rajib Das Saikat Mitra Mohammed Merae Alshahrani Abdulaziz Hassan Alhasaniah Rohit Sharma |
| author_facet | Talha Bin Emran Fahadul Islam Nikhil Nath Hriday Sutradhar Rajib Das Saikat Mitra Mohammed Merae Alshahrani Abdulaziz Hassan Alhasaniah Rohit Sharma |
| author_sort | Talha Bin Emran |
| collection | DOAJ |
| description | The glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. The higher glutathione/oxidized glutathione ratio in 3-NP-induced rats is attributed to the ability of naringin to reduce hydroxyl radical, hydroperoxide, and nitrite. However, although progress has been made in treating these diseases, there are still global concerns about how to obtain a solution. Thus, natural compounds can provide a promising strategy for treating many neurological conditions. Possible therapeutics for neurodegenerative disorders include naringin and naringenin polyphenols. New experimental evidence shows that these polyphenols exert a wide range of pharmacological activity; particular attention was paid to neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, as well as other neurological conditions such as anxiety, depression, schizophrenia, and chronic hyperglycemic peripheral neuropathy. Several preliminary investigations have shown promising evidence of neuroprotection. The main objective of this review was to reflect on developments in understanding the molecular mechanisms underlying the development of naringin and naringenin as potential neuroprotective medications. Furthermore, the configuration relationships between naringin and naringenin are discussed, as well as their plant sources and extraction methods. |
| first_indexed | 2024-03-09T11:57:34Z |
| format | Article |
| id | doaj.art-5b02baaa6d874345bdafd242a4669686 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T11:57:34Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-5b02baaa6d874345bdafd242a46696862023-11-30T23:08:01ZengMDPI AGLife2075-17292022-12-011319910.3390/life13010099Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic ViewpointTalha Bin Emran0Fahadul Islam1Nikhil Nath2Hriday Sutradhar3Rajib Das4Saikat Mitra5Mohammed Merae Alshahrani6Abdulaziz Hassan Alhasaniah7Rohit Sharma8Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, BangladeshDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, BangladeshDepartment of Pharmacy, International Islamic University Chittagong, Chittagong 4318, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, BangladeshDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi ArabiaDepartment of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, P.O. Box 1988, Najran 61441, Saudi ArabiaDepartment of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, IndiaThe glycosides of two flavonoids, naringin and naringenin, are found in various citrus fruits, bergamots, tomatoes, and other fruits. These phytochemicals are associated with multiple biological functions, including neuroprotective, antioxidant, anticancer, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. The higher glutathione/oxidized glutathione ratio in 3-NP-induced rats is attributed to the ability of naringin to reduce hydroxyl radical, hydroperoxide, and nitrite. However, although progress has been made in treating these diseases, there are still global concerns about how to obtain a solution. Thus, natural compounds can provide a promising strategy for treating many neurological conditions. Possible therapeutics for neurodegenerative disorders include naringin and naringenin polyphenols. New experimental evidence shows that these polyphenols exert a wide range of pharmacological activity; particular attention was paid to neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, as well as other neurological conditions such as anxiety, depression, schizophrenia, and chronic hyperglycemic peripheral neuropathy. Several preliminary investigations have shown promising evidence of neuroprotection. The main objective of this review was to reflect on developments in understanding the molecular mechanisms underlying the development of naringin and naringenin as potential neuroprotective medications. Furthermore, the configuration relationships between naringin and naringenin are discussed, as well as their plant sources and extraction methods.https://www.mdpi.com/2075-1729/13/1/99naringinnaringeninpolyphenolsneurological diseasedietary interventions |
| spellingShingle | Talha Bin Emran Fahadul Islam Nikhil Nath Hriday Sutradhar Rajib Das Saikat Mitra Mohammed Merae Alshahrani Abdulaziz Hassan Alhasaniah Rohit Sharma Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint Life naringin naringenin polyphenols neurological disease dietary interventions |
| title | Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint |
| title_full | Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint |
| title_fullStr | Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint |
| title_full_unstemmed | Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint |
| title_short | Naringin and Naringenin Polyphenols in Neurological Diseases: Understandings from a Therapeutic Viewpoint |
| title_sort | naringin and naringenin polyphenols in neurological diseases understandings from a therapeutic viewpoint |
| topic | naringin naringenin polyphenols neurological disease dietary interventions |
| url | https://www.mdpi.com/2075-1729/13/1/99 |
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