TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions
Background: Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1–TLR9, TLR11–TLR13) in mice and 10 members (TLR1–TLR10) in humans, with TLR10 being the latest identified. Summary: Considerable research ha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-01-01
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| Series: | Journal of Innate Immunity |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/535523 |
| _version_ | 1797306798308327424 |
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| author | Carolina Rego Rodrigues Yadu Balachandran Gurpreet Kaur Aulakh Baljit Singh |
| author_facet | Carolina Rego Rodrigues Yadu Balachandran Gurpreet Kaur Aulakh Baljit Singh |
| author_sort | Carolina Rego Rodrigues |
| collection | DOAJ |
| description | Background: Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1–TLR9, TLR11–TLR13) in mice and 10 members (TLR1–TLR10) in humans, with TLR10 being the latest identified. Summary: Considerable research has been performed on TLRs; however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing towards the potential TLR10 ligands, their function and signalling pathway are yet to be determined. Key Messages: This review gives an insight into recent findings on TLR10’s pro- and anti-inflammatory properties, with the goal of outlining existing results and indicating future research topics on this receptor. |
| first_indexed | 2024-03-08T00:47:02Z |
| format | Article |
| id | doaj.art-5b0522c3b2214eb8a13ce26a051b4de8 |
| institution | Directory Open Access Journal |
| issn | 1662-8128 |
| language | English |
| last_indexed | 2024-03-08T00:47:02Z |
| publishDate | 2024-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Journal of Innate Immunity |
| spelling | doaj.art-5b0522c3b2214eb8a13ce26a051b4de82024-02-15T07:38:01ZengKarger PublishersJournal of Innate Immunity1662-81282024-01-011619610410.1159/000535523535523TLR10: An Intriguing Toll-Like Receptor with Many Unanswered QuestionsCarolina Rego Rodrigues0Yadu Balachandran1Gurpreet Kaur Aulakh2Baljit Singh3Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, CanadaVeterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, CanadaSmall Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, CanadaVeterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, CanadaBackground: Toll-like receptors (TLRs) are one of the first pattern recognition receptors found in the innate immune system. The TLR family has 12 members (TLR1–TLR9, TLR11–TLR13) in mice and 10 members (TLR1–TLR10) in humans, with TLR10 being the latest identified. Summary: Considerable research has been performed on TLRs; however, TLR10 is known as an orphan receptor for the lack of information on its signalling, role, and ligands. Even though there are recent studies pointing towards the potential TLR10 ligands, their function and signalling pathway are yet to be determined. Key Messages: This review gives an insight into recent findings on TLR10’s pro- and anti-inflammatory properties, with the goal of outlining existing results and indicating future research topics on this receptor.https://beta.karger.com/Article/FullText/535523inflammationtlr10innate immunitylung |
| spellingShingle | Carolina Rego Rodrigues Yadu Balachandran Gurpreet Kaur Aulakh Baljit Singh TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions Journal of Innate Immunity inflammation tlr10 innate immunity lung |
| title | TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions |
| title_full | TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions |
| title_fullStr | TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions |
| title_full_unstemmed | TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions |
| title_short | TLR10: An Intriguing Toll-Like Receptor with Many Unanswered Questions |
| title_sort | tlr10 an intriguing toll like receptor with many unanswered questions |
| topic | inflammation tlr10 innate immunity lung |
| url | https://beta.karger.com/Article/FullText/535523 |
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