Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine
The enteric nervous system (ENS), known as the intrinsic nervous system of the gastrointestinal tract, is composed of a diverse array of neuronal and glial cell subtypes. Fascinating questions surrounding the generation of cellular diversity in the ENS have captivated ENS biologists for a considerab...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/15/12475 |
| _version_ | 1797586599616184320 |
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| author | Marie A. Lefèvre Rodolphe Soret Nicolas Pilon |
| author_facet | Marie A. Lefèvre Rodolphe Soret Nicolas Pilon |
| author_sort | Marie A. Lefèvre |
| collection | DOAJ |
| description | The enteric nervous system (ENS), known as the intrinsic nervous system of the gastrointestinal tract, is composed of a diverse array of neuronal and glial cell subtypes. Fascinating questions surrounding the generation of cellular diversity in the ENS have captivated ENS biologists for a considerable time, particularly with recent advancements in cell type-specific transcriptomics at both population and single-cell levels. However, the current focus of research in this field is predominantly restricted to the study of enteric neuron subtypes, while the investigation of enteric glia subtypes significantly lags behind. Despite this, enteric glial cells (EGCs) are increasingly recognized as equally important regulators of numerous bowel functions. Moreover, a subset of postnatal EGCs exhibits remarkable plasticity and multipotency, distinguishing them as critical entities in the context of advancing regenerative medicine. In this review, we aim to provide an updated overview of the current knowledge on this subject, while also identifying key questions that necessitate future exploration. |
| first_indexed | 2024-03-11T00:24:21Z |
| format | Article |
| id | doaj.art-5b05c4be3be3430286fd42710b628ef6 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T00:24:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5b05c4be3be3430286fd42710b628ef62023-11-18T23:05:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124151247510.3390/ijms241512475Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative MedicineMarie A. Lefèvre0Rodolphe Soret1Nicolas Pilon2Département des Sciences Biologiques, Université du Québec à Montréal (UQAM), Montreal, QC H3C 3P8, CanadaDépartement des Sciences Biologiques, Université du Québec à Montréal (UQAM), Montreal, QC H3C 3P8, CanadaDépartement des Sciences Biologiques, Université du Québec à Montréal (UQAM), Montreal, QC H3C 3P8, CanadaThe enteric nervous system (ENS), known as the intrinsic nervous system of the gastrointestinal tract, is composed of a diverse array of neuronal and glial cell subtypes. Fascinating questions surrounding the generation of cellular diversity in the ENS have captivated ENS biologists for a considerable time, particularly with recent advancements in cell type-specific transcriptomics at both population and single-cell levels. However, the current focus of research in this field is predominantly restricted to the study of enteric neuron subtypes, while the investigation of enteric glia subtypes significantly lags behind. Despite this, enteric glial cells (EGCs) are increasingly recognized as equally important regulators of numerous bowel functions. Moreover, a subset of postnatal EGCs exhibits remarkable plasticity and multipotency, distinguishing them as critical entities in the context of advancing regenerative medicine. In this review, we aim to provide an updated overview of the current knowledge on this subject, while also identifying key questions that necessitate future exploration.https://www.mdpi.com/1422-0067/24/15/12475neural crest cellsSchwann cellsenteric glial cellsdiversityplasticitymultipotency |
| spellingShingle | Marie A. Lefèvre Rodolphe Soret Nicolas Pilon Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine International Journal of Molecular Sciences neural crest cells Schwann cells enteric glial cells diversity plasticity multipotency |
| title | Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine |
| title_full | Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine |
| title_fullStr | Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine |
| title_full_unstemmed | Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine |
| title_short | Harnessing the Power of Enteric Glial Cells’ Plasticity and Multipotency for Advancing Regenerative Medicine |
| title_sort | harnessing the power of enteric glial cells plasticity and multipotency for advancing regenerative medicine |
| topic | neural crest cells Schwann cells enteric glial cells diversity plasticity multipotency |
| url | https://www.mdpi.com/1422-0067/24/15/12475 |
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