Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine
The regeneration of soft tissues that connect, support or surround other tissues is of great interest. In this sense, hydrogels have great potential as scaffolds for their regeneration. Among the different raw materials, chitosan stands out for being highly biocompatible, which, together with its bi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/13/13/2189 |
| _version_ | 1797528127081021440 |
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| author | Pablo Sánchez-Cid Mercedes Jiménez-Rosado María Alonso-González Alberto Romero Victor Perez-Puyana |
| author_facet | Pablo Sánchez-Cid Mercedes Jiménez-Rosado María Alonso-González Alberto Romero Victor Perez-Puyana |
| author_sort | Pablo Sánchez-Cid |
| collection | DOAJ |
| description | The regeneration of soft tissues that connect, support or surround other tissues is of great interest. In this sense, hydrogels have great potential as scaffolds for their regeneration. Among the different raw materials, chitosan stands out for being highly biocompatible, which, together with its biodegradability and structure, makes it a great alternative for the manufacture of hydrogels. Therefore, the aim of this work was to develop and characterize chitosan hydrogels. To this end, the most important parameters of their processing, i.e., agitation time, pH, gelation temperature and concentration of the biopolymer used were rheologically evaluated. The results show that the agitation time does not have a significant influence on hydrogels, whereas a change in pH (from 3.2 to 7) is a key factor for their formation. Furthermore, a low gelation temperature (4 °C) favors the formation of the hydrogel, showing better mechanical properties. Finally, there is a percentage of biopolymer saturation, from which the properties of the hydrogels are not further improved (1.5 wt.%). This work addresses the development of hydrogels with high thermal resistance, which allows their use as scaffolds without damaging their mechanical properties. |
| first_indexed | 2024-03-10T09:53:42Z |
| format | Article |
| id | doaj.art-5b06ab14527f4a47b81564bd55d86ffb |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T09:53:42Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5b06ab14527f4a47b81564bd55d86ffb2023-11-22T02:31:47ZengMDPI AGPolymers2073-43602021-06-011313218910.3390/polym13132189Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative MedicinePablo Sánchez-Cid0Mercedes Jiménez-Rosado1María Alonso-González2Alberto Romero3Victor Perez-Puyana4Department of Chemical Engineering, Faculty of Chemistry, Universidad de Sevilla, 41012 Sevilla, SpainDepartment of Chemical Engineering, Higher Polytechnic School, Universidad de Sevilla, 41012 Sevilla, SpainDepartment of Chemical Engineering, Higher Polytechnic School, Universidad de Sevilla, 41012 Sevilla, SpainDepartment of Chemical Engineering, Faculty of Chemistry, Universidad de Sevilla, 41012 Sevilla, SpainDepartment of Chemical Engineering, Faculty of Chemistry, Universidad de Sevilla, 41012 Sevilla, SpainThe regeneration of soft tissues that connect, support or surround other tissues is of great interest. In this sense, hydrogels have great potential as scaffolds for their regeneration. Among the different raw materials, chitosan stands out for being highly biocompatible, which, together with its biodegradability and structure, makes it a great alternative for the manufacture of hydrogels. Therefore, the aim of this work was to develop and characterize chitosan hydrogels. To this end, the most important parameters of their processing, i.e., agitation time, pH, gelation temperature and concentration of the biopolymer used were rheologically evaluated. The results show that the agitation time does not have a significant influence on hydrogels, whereas a change in pH (from 3.2 to 7) is a key factor for their formation. Furthermore, a low gelation temperature (4 °C) favors the formation of the hydrogel, showing better mechanical properties. Finally, there is a percentage of biopolymer saturation, from which the properties of the hydrogels are not further improved (1.5 wt.%). This work addresses the development of hydrogels with high thermal resistance, which allows their use as scaffolds without damaging their mechanical properties.https://www.mdpi.com/2073-4360/13/13/2189chitosanhydrogelsoft tissueregenerative medicinepH changethermal resistance |
| spellingShingle | Pablo Sánchez-Cid Mercedes Jiménez-Rosado María Alonso-González Alberto Romero Victor Perez-Puyana Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine Polymers chitosan hydrogel soft tissue regenerative medicine pH change thermal resistance |
| title | Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine |
| title_full | Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine |
| title_fullStr | Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine |
| title_full_unstemmed | Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine |
| title_short | Applied Rheology as Tool for the Assessment of Chitosan Hydrogels for Regenerative Medicine |
| title_sort | applied rheology as tool for the assessment of chitosan hydrogels for regenerative medicine |
| topic | chitosan hydrogel soft tissue regenerative medicine pH change thermal resistance |
| url | https://www.mdpi.com/2073-4360/13/13/2189 |
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