TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma

Abstract Glioblastoma (GB) IDH-wildtype is the most malignant primary brain tumor. It is particularly resistant to current immunotherapies. Translocator protein 18 kDa (TSPO) is upregulated in GB and correlates with malignancy and poor prognosis, but also with increased immune infiltration. Here, we...

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Main Authors: Ayse N. Menevse, Laura-Marie Ammer, Arabel Vollmann-Zwerenz, Marcell Kupczyk, Julia Lorenz, Lorraine Weidner, Abir Hussein, Julian Sax, Jasmin Mühlbauer, Nicole Heuschneider, Celine Rohrmus, Laura S. Mai, Birgit Jachnik, Slava Stamova, Valentina Volpin, Franziska C. Durst, Antonio Sorrentino, Maria Xydia, Vladimir M. Milenkovic, Stefanie Bader, Frank K. Braun, Christian Wetzel, Nathalie L. Albert, Joerg-Christian Tonn, Peter Bartenstein, Martin Proescholdt, Nils O. Schmidt, Ralf A. Linker, Markus J. Riemenschneider, Philipp Beckhove, Peter Hau
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Acta Neuropathologica Communications
Subjects:
TSPO
GB
Anti-tumor immunity
Immune-resistance
TRAIL-resistance
Online Access:https://doi.org/10.1186/s40478-023-01550-9

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