Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review
Abstract Background Carbon ion radiotherapy (CIRT) has been applied in cancer treatment for over 25 years. However, guidelines for dose–volume constraints have not been established yet. The aim of this review is to summarize the dose–volume constraints in CIRT for head‐and‐neck (HN) cancer that were...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5641 |
| _version_ | 1797838372265263104 |
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| author | Maria Varnava Atsushi Musha Mutsumi Tashiro Nobuteru Kubo Naoko Okano Hidemasa Kawamura Tatsuya Ohno |
| author_facet | Maria Varnava Atsushi Musha Mutsumi Tashiro Nobuteru Kubo Naoko Okano Hidemasa Kawamura Tatsuya Ohno |
| author_sort | Maria Varnava |
| collection | DOAJ |
| description | Abstract Background Carbon ion radiotherapy (CIRT) has been applied in cancer treatment for over 25 years. However, guidelines for dose–volume constraints have not been established yet. The aim of this review is to summarize the dose–volume constraints in CIRT for head‐and‐neck (HN) cancer that were determined through previous clinical studies based on the Japanese models for relative biological effectiveness (RBE). Methods A literature review was conducted to identify all constraints determined for HN cancer CIRT that are based on the Japanese RBE models. Results Dose–volume constraints are reported for 17 organs at risk (OARs), including the brainstem, ocular structures, masticatory muscles, and skin. Various treatment planning strategies are also presented for reducing the dose delivered to OARs. Conclusions The reported constraints will provide assistance during treatment planning to ensure that radiation to OARs is minimized, and thus adverse effects are reduced. Although the constraints are given based on the Japanese RBE models, applying the necessary conversion factors will potentially enable their application by institutions worldwide that use the local effect model for RBE. |
| first_indexed | 2024-04-09T15:40:48Z |
| format | Article |
| id | doaj.art-5b0a051ec718487588edaefb3dc38b70 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-09T15:40:48Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-5b0a051ec718487588edaefb3dc38b702023-04-27T10:12:43ZengWileyCancer Medicine2045-76342023-04-011278267827710.1002/cam4.5641Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature reviewMaria Varnava0Atsushi Musha1Mutsumi Tashiro2Nobuteru Kubo3Naoko Okano4Hidemasa Kawamura5Tatsuya Ohno6Gunma University Heavy Ion Medical Center Maebashi Gunma JapanGunma University Heavy Ion Medical Center Maebashi Gunma JapanGunma University Heavy Ion Medical Center Maebashi Gunma JapanGunma University Heavy Ion Medical Center Maebashi Gunma JapanGunma University Heavy Ion Medical Center Maebashi Gunma JapanGunma University Heavy Ion Medical Center Maebashi Gunma JapanGunma University Heavy Ion Medical Center Maebashi Gunma JapanAbstract Background Carbon ion radiotherapy (CIRT) has been applied in cancer treatment for over 25 years. However, guidelines for dose–volume constraints have not been established yet. The aim of this review is to summarize the dose–volume constraints in CIRT for head‐and‐neck (HN) cancer that were determined through previous clinical studies based on the Japanese models for relative biological effectiveness (RBE). Methods A literature review was conducted to identify all constraints determined for HN cancer CIRT that are based on the Japanese RBE models. Results Dose–volume constraints are reported for 17 organs at risk (OARs), including the brainstem, ocular structures, masticatory muscles, and skin. Various treatment planning strategies are also presented for reducing the dose delivered to OARs. Conclusions The reported constraints will provide assistance during treatment planning to ensure that radiation to OARs is minimized, and thus adverse effects are reduced. Although the constraints are given based on the Japanese RBE models, applying the necessary conversion factors will potentially enable their application by institutions worldwide that use the local effect model for RBE.https://doi.org/10.1002/cam4.5641carbon ion radiotherapydose–volume constraintshead‐and‐neck cancerorgans at risk |
| spellingShingle | Maria Varnava Atsushi Musha Mutsumi Tashiro Nobuteru Kubo Naoko Okano Hidemasa Kawamura Tatsuya Ohno Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review Cancer Medicine carbon ion radiotherapy dose–volume constraints head‐and‐neck cancer organs at risk |
| title | Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review |
| title_full | Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review |
| title_fullStr | Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review |
| title_full_unstemmed | Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review |
| title_short | Dose–volume constraints for head‐and‐neck cancer in carbon ion radiotherapy: A literature review |
| title_sort | dose volume constraints for head and neck cancer in carbon ion radiotherapy a literature review |
| topic | carbon ion radiotherapy dose–volume constraints head‐and‐neck cancer organs at risk |
| url | https://doi.org/10.1002/cam4.5641 |
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