Novel 3D µtissues Mimicking the Fibrotic Stroma in Pancreatic Cancer to Study Cellular Interactions and Stroma-Modulating Therapeutics

Novel 3D µtissues Mimicking the Fibrotic Stroma in Pancreatic Cancer to Study Cellular Interactions and Stroma-Modulating Therapeutics

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor type with low patient survival due to the low efficacy of current treatment options. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) create a dense fibrotic environment around the tumor cells, preventing th...

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Bibliographic Details
Main Authors: Kunal P. Pednekar, Marcel A. Heinrich, Joop van Baarlen, Jai Prakash
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
3D in-vitro model
3D µtissues
primary pancreatic stellate cells
cancer-associated fibroblasts
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/19/5006

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