Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems
Significant advanced have recently been made in exploiting microneedle-based (MN-based) diabetes devices for minimally invasive wearable biosensors and for continuous glucose monitoring. Within this emerging class of skin-worn MN-based sensors, the ISF can be utilized as a rich biomarker source to d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/8/606 |
| _version_ | 1797439206607290368 |
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| author | Jian Ju Lin Li Sagar Regmi Xinyu Zhang Shixing Tang |
| author_facet | Jian Ju Lin Li Sagar Regmi Xinyu Zhang Shixing Tang |
| author_sort | Jian Ju |
| collection | DOAJ |
| description | Significant advanced have recently been made in exploiting microneedle-based (MN-based) diabetes devices for minimally invasive wearable biosensors and for continuous glucose monitoring. Within this emerging class of skin-worn MN-based sensors, the ISF can be utilized as a rich biomarker source to diagnose diabetes. While initial work of MN devices focused on ISF extraction, the recent research trend has been oriented toward developing in vivo glucose sensors coupled with optical or electrochemical (EC) instrumentation. This outlook highlights the essential characteristics of the sensing mechanisms, rational design, sensing properties, and applications. Finally, we describe the opinions about the challenge and prospects of optical and EC MN-based device platforms for the fabrication of wearable biosensors and their application potential in the future. |
| first_indexed | 2024-03-09T11:49:25Z |
| format | Article |
| id | doaj.art-5b0b8354b27a40f2911c3f8df02e5b83 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T11:49:25Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-5b0b8354b27a40f2911c3f8df02e5b832023-11-30T23:17:09ZengMDPI AGBiosensors2079-63742022-08-0112860610.3390/bios12080606Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing SystemsJian Ju0Lin Li1Sagar Regmi2Xinyu Zhang3Shixing Tang4Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, ChinaDepartment of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USAWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, ChinaWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, ChinaSignificant advanced have recently been made in exploiting microneedle-based (MN-based) diabetes devices for minimally invasive wearable biosensors and for continuous glucose monitoring. Within this emerging class of skin-worn MN-based sensors, the ISF can be utilized as a rich biomarker source to diagnose diabetes. While initial work of MN devices focused on ISF extraction, the recent research trend has been oriented toward developing in vivo glucose sensors coupled with optical or electrochemical (EC) instrumentation. This outlook highlights the essential characteristics of the sensing mechanisms, rational design, sensing properties, and applications. Finally, we describe the opinions about the challenge and prospects of optical and EC MN-based device platforms for the fabrication of wearable biosensors and their application potential in the future.https://www.mdpi.com/2079-6374/12/8/606microneedlematerialscontinuous glucose monitoringwearable biosensorelectrochemicalsurface-enhanced Raman spectroscopy |
| spellingShingle | Jian Ju Lin Li Sagar Regmi Xinyu Zhang Shixing Tang Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems Biosensors microneedle materials continuous glucose monitoring wearable biosensor electrochemical surface-enhanced Raman spectroscopy |
| title | Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems |
| title_full | Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems |
| title_fullStr | Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems |
| title_full_unstemmed | Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems |
| title_short | Microneedle-Based Glucose Sensor Platform: From <i>Vitro</i> to Wearable Point-of-Care Testing Systems |
| title_sort | microneedle based glucose sensor platform from i vitro i to wearable point of care testing systems |
| topic | microneedle materials continuous glucose monitoring wearable biosensor electrochemical surface-enhanced Raman spectroscopy |
| url | https://www.mdpi.com/2079-6374/12/8/606 |
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