Induction of Secondary Metabolite Biosynthesis by Deleting the Histone Deacetylase HdaA in the Marine-Derived Fungus <i>Aspergillus terreus</i> RA2905

Induction of Secondary Metabolite Biosynthesis by Deleting the Histone Deacetylase HdaA in the Marine-Derived Fungus <i>Aspergillus terreus</i> RA2905

<i>Aspergillus terreus</i> is well-known for its ability to biosynthesize valuable pharmaceuticals as well as structurally unique secondary metabolites. However, numerous promising cryptic secondary metabolites in this strain regulated by silent gene clusters remain unidentified. In this...

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Bibliographic Details
Main Authors: Yao-Yao Zheng, Zhong-Lian Ma, Jing-Shuai Wu, Chang-Lun Shao, Guang-Shan Yao, Chang-Yun Wang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Journal of Fungi
Subjects:
marine-derived fungi
<i>Aspergillus terreus</i>
histone deacetylase HdaA
deletion
secondary metabolite
azaphilone
Online Access:https://www.mdpi.com/2309-608X/8/10/1024

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