Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment
Abstract Three aqueous plant extracts (Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris) were selected for the biofabrication of gold nanoparticles. The antioxidant activities (i.e., free radical scavenging activity, total phenolic content, and reducing power) of the extracts and how...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018-10-01
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| Series: | Nanoscale Research Letters |
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| Online Access: | http://link.springer.com/article/10.1186/s11671-018-2751-7 |
| _version_ | 1797721845813739520 |
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| author | Eun-Young Ahn You Jeong Lee Jisu Park Pusoon Chun Youmie Park |
| author_facet | Eun-Young Ahn You Jeong Lee Jisu Park Pusoon Chun Youmie Park |
| author_sort | Eun-Young Ahn |
| collection | DOAJ |
| description | Abstract Three aqueous plant extracts (Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris) were selected for the biofabrication of gold nanoparticles. The antioxidant activities (i.e., free radical scavenging activity, total phenolic content, and reducing power) of the extracts and how these activities affected the biofabrication of gold nanoparticles were investigated. P. vulgaris exerted the highest antioxidant activity, followed by A. capillaris and then P. oleracea. P. vulgaris was the most efficient reducing agent in the biofabrication process. Gold nanoparticles biofabricated by P. vulgaris (PV-AuNPs) had a maximum surface plasmon resonance of 530 nm with diverse shapes. High-resolution X-ray diffraction analysis showed that the PV-AuNPs had a face-centered cubic structure. The reaction yield was estimated to be 99.3% by inductively coupled plasma optical emission spectroscopy. The hydrodynamic size was determined to be 45 ± 2 nm with a zeta potential of − 13.99 mV. The PV-AuNPs exerted a dose-dependent antioxidant activity. Remarkably, the highest cytotoxicity of the PV-AuNPs was observed against human colorectal adenocarcinoma cells in the absence of fetal bovine serum, while for human pancreas ductal adenocarcinoma cells, the highest cytotoxicity was observed in the presence of fetal bovine serum. This result demonstrates that P. vulgaris extract was an efficient reducing agent for biofabrication of gold nanoparticles exerting cytotoxicity against cancer cells. |
| first_indexed | 2024-03-12T09:40:02Z |
| format | Article |
| id | doaj.art-5b0ecd677ba74f2d8f6729a895b9c0dd |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T09:40:02Z |
| publishDate | 2018-10-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-5b0ecd677ba74f2d8f6729a895b9c0dd2023-09-02T13:19:56ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2018-10-0113111410.1186/s11671-018-2751-7Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity AssessmentEun-Young Ahn0You Jeong Lee1Jisu Park2Pusoon Chun3Youmie Park4College of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje UniversityCollege of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje UniversityCollege of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje UniversityCollege of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje UniversityCollege of Pharmacy and Inje Institute of Pharmaceutical Sciences and Research, Inje UniversityAbstract Three aqueous plant extracts (Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris) were selected for the biofabrication of gold nanoparticles. The antioxidant activities (i.e., free radical scavenging activity, total phenolic content, and reducing power) of the extracts and how these activities affected the biofabrication of gold nanoparticles were investigated. P. vulgaris exerted the highest antioxidant activity, followed by A. capillaris and then P. oleracea. P. vulgaris was the most efficient reducing agent in the biofabrication process. Gold nanoparticles biofabricated by P. vulgaris (PV-AuNPs) had a maximum surface plasmon resonance of 530 nm with diverse shapes. High-resolution X-ray diffraction analysis showed that the PV-AuNPs had a face-centered cubic structure. The reaction yield was estimated to be 99.3% by inductively coupled plasma optical emission spectroscopy. The hydrodynamic size was determined to be 45 ± 2 nm with a zeta potential of − 13.99 mV. The PV-AuNPs exerted a dose-dependent antioxidant activity. Remarkably, the highest cytotoxicity of the PV-AuNPs was observed against human colorectal adenocarcinoma cells in the absence of fetal bovine serum, while for human pancreas ductal adenocarcinoma cells, the highest cytotoxicity was observed in the presence of fetal bovine serum. This result demonstrates that P. vulgaris extract was an efficient reducing agent for biofabrication of gold nanoparticles exerting cytotoxicity against cancer cells.http://link.springer.com/article/10.1186/s11671-018-2751-7Gold nanoparticlesBiofabricationArtemisia capillarisPortulaca oleraceaPrunella vulgarisAntioxidant activity |
| spellingShingle | Eun-Young Ahn You Jeong Lee Jisu Park Pusoon Chun Youmie Park Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment Nanoscale Research Letters Gold nanoparticles Biofabrication Artemisia capillaris Portulaca oleracea Prunella vulgaris Antioxidant activity |
| title | Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment |
| title_full | Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment |
| title_fullStr | Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment |
| title_full_unstemmed | Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment |
| title_short | Antioxidant Potential of Artemisia capillaris, Portulaca oleracea, and Prunella vulgaris Extracts for Biofabrication of Gold Nanoparticles and Cytotoxicity Assessment |
| title_sort | antioxidant potential of artemisia capillaris portulaca oleracea and prunella vulgaris extracts for biofabrication of gold nanoparticles and cytotoxicity assessment |
| topic | Gold nanoparticles Biofabrication Artemisia capillaris Portulaca oleracea Prunella vulgaris Antioxidant activity |
| url | http://link.springer.com/article/10.1186/s11671-018-2751-7 |
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