Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke
Stroke is one of the most leading causes of death and disability in the world. Complement system activation contributes to pathogenesis and neuronal damage following stroke. There are no defined biological serum markers to determine the severity of stroke in acute phases. The purpose of current stud...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2017-05-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/919 |
| _version_ | 1818271177699753984 |
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| author | Ebrahim Kouchaki Atousa Babamohammadi Hassan Nikoueinejad Mojtaba Sehat |
| author_facet | Ebrahim Kouchaki Atousa Babamohammadi Hassan Nikoueinejad Mojtaba Sehat |
| author_sort | Ebrahim Kouchaki |
| collection | DOAJ |
| description | Stroke is one of the most leading causes of death and disability in the world. Complement system activation contributes to pathogenesis and neuronal damage following stroke. There are no defined biological serum markers to determine the severity of stroke in acute phases. The purpose of current study was to determine the association of three complement activators, namely Pentraxin-3 (PTX3),M-ficolin, and Surfactant protein A (SPA) with the severity of ischemic stroke. This cross-sectional study was done on 82 patients diagnosed with ischemic stroke at 24-96 hours of initiation of the clinical symptoms during 2014-2015. The serum levels of PTX3, M-ficolin, and SPA were measured by enzyme-linked immunosorbent assay ( ELISA). The patients were divided in three stroke severity groups according to modified National Institute of Health Stroke Scale mNIHSS. The results showed that the more severity of the stroke was, the higher serum levels of three evaluated molecules (p<0.001) were. The correlation of serum level of PTX3, M-ficolin, and SPA with stroke severity was 0.732, 0.736, and 0.731, respectively. There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke. |
| first_indexed | 2024-12-12T21:22:02Z |
| format | Article |
| id | doaj.art-5b10a00aea1b45cbbc846084489c6440 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-12T21:22:02Z |
| publishDate | 2017-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-5b10a00aea1b45cbbc846084489c64402022-12-22T00:11:33ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492017-05-01162919Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic StrokeEbrahim Kouchaki0Atousa Babamohammadi1Hassan Nikoueinejad2Mojtaba Sehat3Department of Neurology, Kashan University of Medical Sciences, Kashan, IranTrauma Research Center, Kashan University of Medical Sciences, Kashan, IranNephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranDepartment of Community Medicine, Kashan University of medical sciences, Kashan, IranStroke is one of the most leading causes of death and disability in the world. Complement system activation contributes to pathogenesis and neuronal damage following stroke. There are no defined biological serum markers to determine the severity of stroke in acute phases. The purpose of current study was to determine the association of three complement activators, namely Pentraxin-3 (PTX3),M-ficolin, and Surfactant protein A (SPA) with the severity of ischemic stroke. This cross-sectional study was done on 82 patients diagnosed with ischemic stroke at 24-96 hours of initiation of the clinical symptoms during 2014-2015. The serum levels of PTX3, M-ficolin, and SPA were measured by enzyme-linked immunosorbent assay ( ELISA). The patients were divided in three stroke severity groups according to modified National Institute of Health Stroke Scale mNIHSS. The results showed that the more severity of the stroke was, the higher serum levels of three evaluated molecules (p<0.001) were. The correlation of serum level of PTX3, M-ficolin, and SPA with stroke severity was 0.732, 0.736, and 0.731, respectively. There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/919Ischemic strokePentraxin-3M-ficolinSurfactant protein A |
| spellingShingle | Ebrahim Kouchaki Atousa Babamohammadi Hassan Nikoueinejad Mojtaba Sehat Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke Iranian Journal of Allergy, Asthma and Immunology Ischemic stroke Pentraxin-3 M-ficolin Surfactant protein A |
| title | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke |
| title_full | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke |
| title_fullStr | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke |
| title_full_unstemmed | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke |
| title_short | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke |
| title_sort | association of serum levels of pentraxin 3 m ficolin and surfactant protein a with the severity of ischemic stroke |
| topic | Ischemic stroke Pentraxin-3 M-ficolin Surfactant protein A |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/919 |
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