LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma

LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma

Abstract Tumor cells require high levels of cholesterol for membrane biogenesis for rapid proliferation during development. Beyond the acquired cholesterol from low-density lipoprotein (LDL) taken up from circulation, tumor cells can also biosynthesize cholesterol. The molecular mechanism underlying...

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Bibliographic Details
Main Authors: Mingyue Tao, Jing Luo, Tong Gu, Xiaojuan Yu, Zhen Song, Yali Jun, Hao Gu, Kairong Han, Xiujuan Huang, Weiyong Yu, Su’an Sun, Zhengwei Zhang, Lu Liu, Xiaofei Chen, Li Zhang, Chao Luo, Qilong Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04132-6

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