Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis
Abstract Objective The purpose of this study was to comprehensively evaluate the lipid profiles in patients with juvenile idiopathic arthritis (JIA). Methods The literature and relevant reviews were searched for published clinical studies on the relationship between JIA and blood lipid levels. The N...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-023-01885-1 |
| _version_ | 1797556779793514496 |
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| author | Wen-Jia Zhao Jiang-Hong Deng Cai-Feng Li |
| author_facet | Wen-Jia Zhao Jiang-Hong Deng Cai-Feng Li |
| author_sort | Wen-Jia Zhao |
| collection | DOAJ |
| description | Abstract Objective The purpose of this study was to comprehensively evaluate the lipid profiles in patients with juvenile idiopathic arthritis (JIA). Methods The literature and relevant reviews were searched for published clinical studies on the relationship between JIA and blood lipid levels. The Newcastle–Ottawa scale (NOS) was applied to evaluate the risk and methodological value of the included case‒control and cohort studies. Standardized mean differences (SMDs) and 95% confidence intervals were derived for all variables with adequate unprocessed data. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Results In total, 16 studies were incorporated through screening. The analysis findings revealed that the levels of very low-density lipoprotein cholesterol [SMD=-0.411, 95% CI (-0.774~-0.048), P = 0.026], high-density lipoprotein cholesterol [SMD=-0.528, 95% CI (-0.976~-0.079), P = 0.021], and apolipoprotein A1 [SMD=-1.050, 95% CI (-1.452~-0.647), P = 0.000] in JIA patients were statistically lower than those observed in healthy controls. The level of low-density lipoprotein cholesterol [SMD = 0.202, 95% CI (0.003 ~ 0.400), P = 0.046] was significantly higher in JIA patients than in healthy controls. In JIA patients, body mass index [SMD=-0.189, 95% CI (-0.690 ~ 0.311), P = 0.459], high-density lipoprotein [SMD =-1.235, 95% CI (-2.845 ~ 0.374), P = 0.133), low-density lipoprotein [SMD = 0.616, 95% CI (-0.813 ~ 2.046), P = 0.398), triglycerides (SMD = 0.278, 95% CI (-0.182 ~ 0.738), P = 0.236], total cholesterol [SMD=-0.073, 95% CI (-0.438 ~ 0.293), P = 0.696] and apolipoprotein B levels [SMD = 0.226, 95% CI (-0.133 ~ 0.585), P = 0.217] were not significantly different from those in healthy controls. Conclusions The outcomes of this meta-analysis suggest that dyslipidemia is common in JIA patients compared to healthy controls. Patients with JIA have a significantly increased risk of atherosclerosis and cardiovascular disease later in life. |
| first_indexed | 2024-03-10T17:07:49Z |
| format | Article |
| id | doaj.art-5b1273d6691a4c03b065ae98c697072c |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-10T17:07:49Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-5b1273d6691a4c03b065ae98c697072c2023-11-20T10:45:26ZengBMCLipids in Health and Disease1476-511X2023-08-0122111210.1186/s12944-023-01885-1Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysisWen-Jia Zhao0Jiang-Hong Deng1Cai-Feng Li2Department of Rheumatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical UniversityDepartment of Rheumatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical UniversityDepartment of Rheumatology, Beijing Children’s Hospital, National Center for Children’s Health, Capital Medical UniversityAbstract Objective The purpose of this study was to comprehensively evaluate the lipid profiles in patients with juvenile idiopathic arthritis (JIA). Methods The literature and relevant reviews were searched for published clinical studies on the relationship between JIA and blood lipid levels. The Newcastle–Ottawa scale (NOS) was applied to evaluate the risk and methodological value of the included case‒control and cohort studies. Standardized mean differences (SMDs) and 95% confidence intervals were derived for all variables with adequate unprocessed data. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Results In total, 16 studies were incorporated through screening. The analysis findings revealed that the levels of very low-density lipoprotein cholesterol [SMD=-0.411, 95% CI (-0.774~-0.048), P = 0.026], high-density lipoprotein cholesterol [SMD=-0.528, 95% CI (-0.976~-0.079), P = 0.021], and apolipoprotein A1 [SMD=-1.050, 95% CI (-1.452~-0.647), P = 0.000] in JIA patients were statistically lower than those observed in healthy controls. The level of low-density lipoprotein cholesterol [SMD = 0.202, 95% CI (0.003 ~ 0.400), P = 0.046] was significantly higher in JIA patients than in healthy controls. In JIA patients, body mass index [SMD=-0.189, 95% CI (-0.690 ~ 0.311), P = 0.459], high-density lipoprotein [SMD =-1.235, 95% CI (-2.845 ~ 0.374), P = 0.133), low-density lipoprotein [SMD = 0.616, 95% CI (-0.813 ~ 2.046), P = 0.398), triglycerides (SMD = 0.278, 95% CI (-0.182 ~ 0.738), P = 0.236], total cholesterol [SMD=-0.073, 95% CI (-0.438 ~ 0.293), P = 0.696] and apolipoprotein B levels [SMD = 0.226, 95% CI (-0.133 ~ 0.585), P = 0.217] were not significantly different from those in healthy controls. Conclusions The outcomes of this meta-analysis suggest that dyslipidemia is common in JIA patients compared to healthy controls. Patients with JIA have a significantly increased risk of atherosclerosis and cardiovascular disease later in life.https://doi.org/10.1186/s12944-023-01885-1Juvenile idiopathic arthritisLipid profileMeta-analysisRheumatology |
| spellingShingle | Wen-Jia Zhao Jiang-Hong Deng Cai-Feng Li Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis Lipids in Health and Disease Juvenile idiopathic arthritis Lipid profile Meta-analysis Rheumatology |
| title | Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis |
| title_full | Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis |
| title_fullStr | Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis |
| title_full_unstemmed | Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis |
| title_short | Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis |
| title_sort | lipid profiles in patients with juvenile idiopathic arthritis a systematic literature review and meta analysis |
| topic | Juvenile idiopathic arthritis Lipid profile Meta-analysis Rheumatology |
| url | https://doi.org/10.1186/s12944-023-01885-1 |
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