Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews
Background: Growing evidence supports exercise for people with lung cancer. This overview aimed to summarise exercise intervention efficacy and safety across the care continuum. Methods: Eight databases (including Cochrane and Medline) were searched (inception—February 2022) for systematic reviews o...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1871 |
| _version_ | 1797615018483646464 |
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| author | Lara Edbrooke Amy Bowman Catherine L. Granger Nicola Burgess Shaza Abo Bronwen Connolly Linda Denehy |
| author_facet | Lara Edbrooke Amy Bowman Catherine L. Granger Nicola Burgess Shaza Abo Bronwen Connolly Linda Denehy |
| author_sort | Lara Edbrooke |
| collection | DOAJ |
| description | Background: Growing evidence supports exercise for people with lung cancer. This overview aimed to summarise exercise intervention efficacy and safety across the care continuum. Methods: Eight databases (including Cochrane and Medline) were searched (inception—February 2022) for systematic reviews of RCTs/quasi-RCTs. Eligibility: population—adults with lung cancer; intervention: exercise (e.g., aerobic, resistance) +/− non-exercise (e.g., nutrition); comparator: usual care/non-exercise; primary outcomes: exercise capacity, physical function, health-related quality of life (HRQoL) and post-operative complications. Duplicate, independent title/abstract and full-text screening, data extraction and quality ratings (AMSTAR-2) were completed. Results: Thirty systematic reviews involving between 157 and 2109 participants (n = 6440 total) were included. Most reviews (n = 28) involved surgical participants. Twenty-five reviews performed meta-analyses. The review quality was commonly rated critically low (n = 22) or low (n = 7). Reviews commonly included combinations of aerobic, resistance and/or respiratory exercise interventions. Pre-operative meta-analyses demonstrated that exercise reduces post-operative complications (n = 4/7) and improves exercise capacity (n = 6/6), whilst HRQoL findings were non-significant (n = 3/3). Post-operative meta-analyses reported significant improvements in exercise capacity (n = 2/3) and muscle strength (n = 1/1) and non-significant HRQoL changes (n = 8/10). Interventions delivered to mixed surgical and non-surgical populations improved exercise capacity (n = 3/4), muscle strength (n = 2/2) and HRQoL (n = 3). Meta-analyses of interventions in non-surgical populations demonstrated inconsistent findings. Adverse event rates were low, however, few reviews reported on safety. Conclusions: A large body of evidence supports lung cancer exercise interventions to reduce complications and improve exercise capacity in pre- and post-operative populations. Additional higher-quality research is needed, particularly in the non-surgical population, including subgroup analyses of exercise type and setting. |
| first_indexed | 2024-03-11T07:20:31Z |
| format | Article |
| id | doaj.art-5b12b4cc0ac04427bcbc4da900c479f6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:20:31Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5b12b4cc0ac04427bcbc4da900c479f62023-11-17T07:59:29ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125187110.3390/jcm12051871Exercise across the Lung Cancer Care Continuum: An Overview of Systematic ReviewsLara Edbrooke0Amy Bowman1Catherine L. Granger2Nicola Burgess3Shaza Abo4Bronwen Connolly5Linda Denehy6Department of Physiotherapy, The University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Physiotherapy, The University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Physiotherapy, The University of Melbourne, Melbourne, VIC 3010, AustraliaDepartment of Physiotherapy, Austin Health, Melbourne, VIC 3084, AustraliaDepartment of Physiotherapy, The University of Melbourne, Melbourne, VIC 3010, AustraliaWellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast BT7 1NN, UKDepartment of Physiotherapy, The University of Melbourne, Melbourne, VIC 3010, AustraliaBackground: Growing evidence supports exercise for people with lung cancer. This overview aimed to summarise exercise intervention efficacy and safety across the care continuum. Methods: Eight databases (including Cochrane and Medline) were searched (inception—February 2022) for systematic reviews of RCTs/quasi-RCTs. Eligibility: population—adults with lung cancer; intervention: exercise (e.g., aerobic, resistance) +/− non-exercise (e.g., nutrition); comparator: usual care/non-exercise; primary outcomes: exercise capacity, physical function, health-related quality of life (HRQoL) and post-operative complications. Duplicate, independent title/abstract and full-text screening, data extraction and quality ratings (AMSTAR-2) were completed. Results: Thirty systematic reviews involving between 157 and 2109 participants (n = 6440 total) were included. Most reviews (n = 28) involved surgical participants. Twenty-five reviews performed meta-analyses. The review quality was commonly rated critically low (n = 22) or low (n = 7). Reviews commonly included combinations of aerobic, resistance and/or respiratory exercise interventions. Pre-operative meta-analyses demonstrated that exercise reduces post-operative complications (n = 4/7) and improves exercise capacity (n = 6/6), whilst HRQoL findings were non-significant (n = 3/3). Post-operative meta-analyses reported significant improvements in exercise capacity (n = 2/3) and muscle strength (n = 1/1) and non-significant HRQoL changes (n = 8/10). Interventions delivered to mixed surgical and non-surgical populations improved exercise capacity (n = 3/4), muscle strength (n = 2/2) and HRQoL (n = 3). Meta-analyses of interventions in non-surgical populations demonstrated inconsistent findings. Adverse event rates were low, however, few reviews reported on safety. Conclusions: A large body of evidence supports lung cancer exercise interventions to reduce complications and improve exercise capacity in pre- and post-operative populations. Additional higher-quality research is needed, particularly in the non-surgical population, including subgroup analyses of exercise type and setting.https://www.mdpi.com/2077-0383/12/5/1871lung cancerexerciserehabilitationoverview of reviews |
| spellingShingle | Lara Edbrooke Amy Bowman Catherine L. Granger Nicola Burgess Shaza Abo Bronwen Connolly Linda Denehy Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews Journal of Clinical Medicine lung cancer exercise rehabilitation overview of reviews |
| title | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
| title_full | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
| title_fullStr | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
| title_full_unstemmed | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
| title_short | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
| title_sort | exercise across the lung cancer care continuum an overview of systematic reviews |
| topic | lung cancer exercise rehabilitation overview of reviews |
| url | https://www.mdpi.com/2077-0383/12/5/1871 |
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