Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway

Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway

In recent study, the pathological mechanism of liver fibrosis has been associated with hepatic stellate cell (HSC) senescence. Targeted induction of HSC senescence is considered as a new strategy to remove activated HSC. Nevertheless, little is known about the role of ferritinophagy in cell senescen...

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Bibliographic Details
Main Authors: Ying Sun, Jingdan Weng, Xiaolei Chen, Shuyao Ma, Yuxin Zhang, Feng Zhang, Zili Zhang, Feixia Wang, Jiangjuan Shao, Shizhong Zheng
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Liver fibrosis
Oroxylin A
Cell senescence
Ferritinophagy
cGAS-STING pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223004419

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