Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report
Introduction: Regression of malignant melanoma (MM) is a commonly observed phenomenon, which refers to disappearance or loss of all or part of MM. It can be identified both clinically and histologically, and high probability of histological regression of MM (10–58%) has been reported. However, the d...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-12-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://beta.karger.com/Article/FullText/535194 |
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| author | Yasuaki Ikuno Hiraku Kokubu Miwa Kato Kazuma Okada Akihiko Yamaguchi Toshifumi Takahashi Takeshi Kato Noriki Fujimoto |
| author_facet | Yasuaki Ikuno Hiraku Kokubu Miwa Kato Kazuma Okada Akihiko Yamaguchi Toshifumi Takahashi Takeshi Kato Noriki Fujimoto |
| author_sort | Yasuaki Ikuno |
| collection | DOAJ |
| description | Introduction: Regression of malignant melanoma (MM) is a commonly observed phenomenon, which refers to disappearance or loss of all or part of MM. It can be identified both clinically and histologically, and high probability of histological regression of MM (10–58%) has been reported. However, the decapitation of skin tumor has rarely been described in the English literature, and decapitation in MM has not been reported. Here, we report the case of polypoid MM with spontaneous decapitation. Case Presentation: An 81-year-old Japanese woman was referred to our hospital due to a polypoid nodule on her cheek. She was diagnosed with MM at stage IIC (T4bN0M0) by histological examinations. Three weeks after the biopsy, the nodule decapitated spontaneously without bleeding, and an ulcer developed on the base of the polypoid nodule. The histological examination of the additionally resected ulcerative lesion under the nodule revealed infiltration of T cells mainly composed of CD8⁺ natural killer T cells. No recurrence or metastasis has been observed for 4 years. Conclusion: This is the first case report of polypoid MM with spontaneous decapitation, which may be attributed to natural killer T cells. Moreover, this case shows favorable prognosis, while it is said that the regression in thick MM does not have prognostic advantage and polypoid topography has been reported to be related to extremely poor prognosis. Further investigations are needed to evaluate the prognostic advantage of decapitation in MM and other skin tumors. |
| first_indexed | 2024-03-08T14:47:56Z |
| format | Article |
| id | doaj.art-5b15341ab0f74eebb0b2623c3964b880 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-08T14:47:56Z |
| publishDate | 2023-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-5b15341ab0f74eebb0b2623c3964b8802024-01-11T08:00:57ZengKarger PublishersCase Reports in Oncology1662-65752023-12-011611568157210.1159/000535194535194Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case ReportYasuaki Ikuno0Hiraku Kokubu1Miwa Kato2Kazuma Okada3Akihiko Yamaguchi4Toshifumi Takahashi5Takeshi Kato6Noriki Fujimoto7Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanDepartment of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, JapanIntroduction: Regression of malignant melanoma (MM) is a commonly observed phenomenon, which refers to disappearance or loss of all or part of MM. It can be identified both clinically and histologically, and high probability of histological regression of MM (10–58%) has been reported. However, the decapitation of skin tumor has rarely been described in the English literature, and decapitation in MM has not been reported. Here, we report the case of polypoid MM with spontaneous decapitation. Case Presentation: An 81-year-old Japanese woman was referred to our hospital due to a polypoid nodule on her cheek. She was diagnosed with MM at stage IIC (T4bN0M0) by histological examinations. Three weeks after the biopsy, the nodule decapitated spontaneously without bleeding, and an ulcer developed on the base of the polypoid nodule. The histological examination of the additionally resected ulcerative lesion under the nodule revealed infiltration of T cells mainly composed of CD8⁺ natural killer T cells. No recurrence or metastasis has been observed for 4 years. Conclusion: This is the first case report of polypoid MM with spontaneous decapitation, which may be attributed to natural killer T cells. Moreover, this case shows favorable prognosis, while it is said that the regression in thick MM does not have prognostic advantage and polypoid topography has been reported to be related to extremely poor prognosis. Further investigations are needed to evaluate the prognostic advantage of decapitation in MM and other skin tumors.https://beta.karger.com/Article/FullText/535194malignant melanomaspontaneous decapitationfavorable prognosis |
| spellingShingle | Yasuaki Ikuno Hiraku Kokubu Miwa Kato Kazuma Okada Akihiko Yamaguchi Toshifumi Takahashi Takeshi Kato Noriki Fujimoto Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report Case Reports in Oncology malignant melanoma spontaneous decapitation favorable prognosis |
| title | Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report |
| title_full | Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report |
| title_fullStr | Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report |
| title_full_unstemmed | Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report |
| title_short | Polypoid Malignant Melanoma with Spontaneous Decapitation Showing Favorable Prognosis: A Case Report |
| title_sort | polypoid malignant melanoma with spontaneous decapitation showing favorable prognosis a case report |
| topic | malignant melanoma spontaneous decapitation favorable prognosis |
| url | https://beta.karger.com/Article/FullText/535194 |
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