Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins
Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress. In addition to overabundance of pro-inflammatory stimuli, excessive and uncontrolled...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-06-01
|
Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/11/6/1213 |
_version_ | 1797490466075181056 |
---|---|
author | Cindy Barnig Gaetan Lutzweiler Margherita Giannini Anne Lejay Anne-Laure Charles Alain Meyer Bernard Geny |
author_facet | Cindy Barnig Gaetan Lutzweiler Margherita Giannini Anne Lejay Anne-Laure Charles Alain Meyer Bernard Geny |
author_sort | Cindy Barnig |
collection | DOAJ |
description | Skeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress. In addition to overabundance of pro-inflammatory stimuli, excessive and uncontrolled inflammation can also result from defects in resolution signaling. Importantly, the resolution of inflammation is an active process also based on specific lipid mediators including lipoxins, resolvins and maresins that orchestrate the potential return to tissue homeostasis. Thus, lipid mediators have received growing attention since they dampen deleterious effects related to ischemia–reperfusion. For instance, the treatment of skeletal muscles with resolvins prior to ischemia decreases polymorphonuclear leukocyte (PMN) infiltration. Additionally, remote alterations in lungs or kidneys are reduced when enhancing lipid mediators’ functions. Accordingly, lipoxins prevented oxidative-stress-mediated tissue injuries, macrophage polarization was modified and in mice lacking DRV2 receptors, ischemia/reperfusion resulted in excessive leukocyte accumulation. In this review, we first aimed to describe the inflammatory response during ischemia and reperfusion in skeletal muscle and then discuss recent discoveries in resolution pathways. We focused on the role of specialized pro-resolving mediators (SPMs) derived from polyunsaturated fatty acids (PUFAs) and their potential therapeutic applications. |
first_indexed | 2024-03-10T00:33:22Z |
format | Article |
id | doaj.art-5b175a6e8eb942ddb863bb4618fa7941 |
institution | Directory Open Access Journal |
issn | 2076-3921 |
language | English |
last_indexed | 2024-03-10T00:33:22Z |
publishDate | 2022-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Antioxidants |
spelling | doaj.art-5b175a6e8eb942ddb863bb4618fa79412023-11-23T15:21:32ZengMDPI AGAntioxidants2076-39212022-06-01116121310.3390/antiox11061213Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and MaresinsCindy Barnig0Gaetan Lutzweiler1Margherita Giannini2Anne Lejay3Anne-Laure Charles4Alain Meyer5Bernard Geny6Team 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, University of Strasbourg, 11 Rue Humann, 67000 Strasbourg, FranceLaboratoire de Polymères, Biopolymères et Surfaces (PBS), Université de Rouen Normandie, 55 Rue Saint-Germain, 27000 Evreux, FranceTeam 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, University of Strasbourg, 11 Rue Humann, 67000 Strasbourg, FranceTeam 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, University of Strasbourg, 11 Rue Humann, 67000 Strasbourg, FranceTeam 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, University of Strasbourg, 11 Rue Humann, 67000 Strasbourg, FranceTeam 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, University of Strasbourg, 11 Rue Humann, 67000 Strasbourg, FranceTeam 3072 “Mitochondria, Oxidative Stress and Muscle Protection”, Translational Medicine Federation of Strasbourg (FMTS), Faculty of Medicine, University of Strasbourg, 11 Rue Humann, 67000 Strasbourg, FranceSkeletal muscle ischemia reperfusion is very frequent in humans and results not only in muscle destruction but also in multi-organ failure and death via systemic effects related to inflammation and oxidative stress. In addition to overabundance of pro-inflammatory stimuli, excessive and uncontrolled inflammation can also result from defects in resolution signaling. Importantly, the resolution of inflammation is an active process also based on specific lipid mediators including lipoxins, resolvins and maresins that orchestrate the potential return to tissue homeostasis. Thus, lipid mediators have received growing attention since they dampen deleterious effects related to ischemia–reperfusion. For instance, the treatment of skeletal muscles with resolvins prior to ischemia decreases polymorphonuclear leukocyte (PMN) infiltration. Additionally, remote alterations in lungs or kidneys are reduced when enhancing lipid mediators’ functions. Accordingly, lipoxins prevented oxidative-stress-mediated tissue injuries, macrophage polarization was modified and in mice lacking DRV2 receptors, ischemia/reperfusion resulted in excessive leukocyte accumulation. In this review, we first aimed to describe the inflammatory response during ischemia and reperfusion in skeletal muscle and then discuss recent discoveries in resolution pathways. We focused on the role of specialized pro-resolving mediators (SPMs) derived from polyunsaturated fatty acids (PUFAs) and their potential therapeutic applications.https://www.mdpi.com/2076-3921/11/6/1213lipid mediatorslipoxinresolvinsprotectins and maresinsinflammationoxidative stress |
spellingShingle | Cindy Barnig Gaetan Lutzweiler Margherita Giannini Anne Lejay Anne-Laure Charles Alain Meyer Bernard Geny Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins Antioxidants lipid mediators lipoxin resolvins protectins and maresins inflammation oxidative stress |
title | Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins |
title_full | Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins |
title_fullStr | Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins |
title_full_unstemmed | Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins |
title_short | Resolution of Inflammation after Skeletal Muscle Ischemia–Reperfusion Injury: A Focus on the Lipid Mediators Lipoxins, Resolvins, Protectins and Maresins |
title_sort | resolution of inflammation after skeletal muscle ischemia reperfusion injury a focus on the lipid mediators lipoxins resolvins protectins and maresins |
topic | lipid mediators lipoxin resolvins protectins and maresins inflammation oxidative stress |
url | https://www.mdpi.com/2076-3921/11/6/1213 |
work_keys_str_mv | AT cindybarnig resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins AT gaetanlutzweiler resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins AT margheritagiannini resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins AT annelejay resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins AT annelaurecharles resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins AT alainmeyer resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins AT bernardgeny resolutionofinflammationafterskeletalmuscleischemiareperfusioninjuryafocusonthelipidmediatorslipoxinsresolvinsprotectinsandmaresins |