Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b wit...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020317990 |
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| author | Reda M. Abdelhameed Osama M. Darwesh Mahmoud El-Shahat |
| author_facet | Reda M. Abdelhameed Osama M. Darwesh Mahmoud El-Shahat |
| author_sort | Reda M. Abdelhameed |
| collection | DOAJ |
| description | Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various aromatic aldehydes. The antimicrobial action for recently synthesized compounds was considered towards gram positive bacterial species (Staphylococcus aurous ATCC- 47077; Bacillus cereus ATCC-12228), gram negative bacterial species (Escherichia coli ATCC-25922; Salmonella typhi ATCC-15566) and Candida albicans ATCC-10231 as fungal strains. The antimicrobial action expanded by expanding the electron donating group in position 2 and 5 for Pyrido[2,3-d]pyrimidin-4-one core. Derivatives 13, 14, 15, 16 and 12; individually appeared hopeful anti-microbial action towards all strains utilized with inhibition zone higher than that of standard reference drug with lowest MIC. |
| first_indexed | 2024-12-12T15:35:57Z |
| format | Article |
| id | doaj.art-5b1a92342bdd49da81e81381f5f284d8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T15:35:57Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-5b1a92342bdd49da81e81381f5f284d82022-12-22T00:20:00ZengElsevierHeliyon2405-84402020-09-0169e04956Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agentsReda M. Abdelhameed0Osama M. Darwesh1Mahmoud El-Shahat2Applied Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, EgyptDepartment of Agricultural Microbiology, Agricultural Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza, 12622, EgyptPhotochemistry Department, Chemical Industries Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza 12622, Egypt; Corresponding author.Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various aromatic aldehydes. The antimicrobial action for recently synthesized compounds was considered towards gram positive bacterial species (Staphylococcus aurous ATCC- 47077; Bacillus cereus ATCC-12228), gram negative bacterial species (Escherichia coli ATCC-25922; Salmonella typhi ATCC-15566) and Candida albicans ATCC-10231 as fungal strains. The antimicrobial action expanded by expanding the electron donating group in position 2 and 5 for Pyrido[2,3-d]pyrimidin-4-one core. Derivatives 13, 14, 15, 16 and 12; individually appeared hopeful anti-microbial action towards all strains utilized with inhibition zone higher than that of standard reference drug with lowest MIC.http://www.sciencedirect.com/science/article/pii/S2405844020317990Organic chemistryPharmaceutical chemistryPyrido[2,3-d]pyrimidin-4-oneHydrazinylpyrido[2,3-d]pyrimidin-4-oneAnti-bacterial activityAnti-fungal activity |
| spellingShingle | Reda M. Abdelhameed Osama M. Darwesh Mahmoud El-Shahat Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents Heliyon Organic chemistry Pharmaceutical chemistry Pyrido[2,3-d]pyrimidin-4-one Hydrazinylpyrido[2,3-d]pyrimidin-4-one Anti-bacterial activity Anti-fungal activity |
| title | Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents |
| title_full | Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents |
| title_fullStr | Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents |
| title_full_unstemmed | Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents |
| title_short | Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents |
| title_sort | synthesis of arylidene hydrazinylpyrido 2 3 d pyrimidin 4 ones as potent anti microbial agents |
| topic | Organic chemistry Pharmaceutical chemistry Pyrido[2,3-d]pyrimidin-4-one Hydrazinylpyrido[2,3-d]pyrimidin-4-one Anti-bacterial activity Anti-fungal activity |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020317990 |
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